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Gut and Vaginal Microbiota Profile Study for HIV Women

NCT ID: NCT05996016

Last Updated: 2025-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-01-01

Study Completion Date

2030-06-30

Brief Summary

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Women Living with HIV Infection （WLHIV）are intended to acquire HPV infection which usually contributes to variable cervical lesions. we hypothesize that vaginal microbiota imbalance may make WLHIV prone to HPV infection，thereafter results in severe cervical lesion.

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Detailed Description

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Women Living with HIV Infection （WLHIV）are intended to acquire HPV infection which usually contributes to variable cervical lesions. Besides the HPV co-infection, microbiota study recently reveals that the changes of vaginal bacteria spectrum might also be related with cervical disease in WLHIV. However, data on HPV prevalence in WLHIV and its associated cervical lesion incidence is still limited in China. Moreover, the causal relationship between vaginal microbiota and cervical lesion in WLHIV is not clear. Here, we hypothesize that vaginal microbiota imbalance may make WLHIV prone to HPV infection，thereafter results in severe cervical lesion.

Conditions

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HPV HIV Infections Vaginal Microbiota

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* HIV women （including pregnant）;
* sign consent paper

Exclusion Criteria

* virgin or maiden
Minimum Eligible Age

14 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Peking Union Medical College Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Wei Lyu, MD

Role: PRINCIPAL_INVESTIGATOR

No. 10Yi，Chaowai Street ，Chaoyang District ，Beijing ，China

Locations

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Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Wei Lyu, MD

Role: CONTACT

[email protected]
13501385800 ext. 010

Zhang Qing

Role: CONTACT

[email protected]
13207572893 ext. 022

Facility Contacts

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Wei Lyu, MD

Role: primary

[email protected]
13501385800 ext. 010

Other Identifiers

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PekingUMCH-K2675

Identifier Type: -

Identifier Source: org_study_id

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