Evaluation of Digit Tip and Split Skin Donor Site Transcriptome

NCT ID: NCT05991765

Last Updated: 2023-08-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

75 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-06-01

Study Completion Date

2023-12-31

Brief Summary

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Regrowth of amputated fingertips presents a unique regenerative healing process in mammals, with subcutaneous volume regrowth, restoration of the dactylogram, and suppression of scar formation. In addition, wound healing from split-thickness donor sites shows almost scar-free healing. Transcriptome analysis is necessary to better understand the specific healing mechanisms of these two wound entities. Since no data are available to date, this study aims to fill the gap.

Detailed Description

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Regrowth of amputated fingertips presents a unique regenerative healing process in mammals, with subcutaneous volume regrowth, restoration of the dactylogram, and suppression of scar formation. In addition, wound healing from split-thickness donor sites shows almost scar-free healing. Transcriptome analysis is necessary to better understand the specific healing mechanisms of these two wound entities. Since no data are available to date, this study aims to fill the gap.

Conditions

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Digit Tip Wound Split Skin Donor Site

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Digit Tip Wound

Experimental Wound Exudate from Digit Tip Wounds

Digit Tip Wound

Intervention Type OTHER

Digit Tip Wound Exudate Sample Collected while Dressing Change

Split Skin Donor Site Wound

Active Comparator Wound Exudate from Split Skin Donor Site Wound

Split Skin Donor Site Wound

Intervention Type OTHER

Split Skin Donor Site Wound Exudate Sample while Dressing Change

Interventions

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Digit Tip Wound

Digit Tip Wound Exudate Sample Collected while Dressing Change

Intervention Type OTHER

Split Skin Donor Site Wound

Split Skin Donor Site Wound Exudate Sample while Dressing Change

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Digit Tip Wound: Wound Exudate from healthy patients: Consent-capable patients ≥18 years of age with clean Digit Tip Wound
2. Split Skin Donor Site Wound: Wound Exudate from healthy patients: Consent-capable patients ≥18 years of age with clean Split Skin Donor Site Wound

Exclusion Criteria

* Inflammation
* Borderline
* Infectious Disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital Schleswig-Holstein

OTHER

Sponsor Role lead

Responsible Party

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Tobias Kisch

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of Schleswig-Holstein

Lübeck, Schleswig-Holstein, Germany

Site Status

Countries

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Germany

Other Identifiers

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DigitTip2023

Identifier Type: -

Identifier Source: org_study_id

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