Study to Evaluate the Safety and Effectiveness of GP0116

NCT ID: NCT05987163

Last Updated: 2025-07-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

186 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-04-12

Study Completion Date

2026-03-31

Brief Summary

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This is a prospective, randomized, evaluator-blinded, comparator-controlled, parallel group, multicenter study in the U.S. for correction of moderate to severe dynamic facial wrinkles and folds, such as nasolabial folds (NLFs).

Detailed Description

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Conditions

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Skin Manifestations

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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GP0116

Group Type EXPERIMENTAL

GP0116

Intervention Type DEVICE

GP0116 is an injectable, sterile, transparent product.

FDA Approved Device

Group Type ACTIVE_COMPARATOR

Active Comparator: FDA approved dermal filler device (RHA 3)

Intervention Type DEVICE

FDA approved dermal filler device (RHA 3)

Interventions

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GP0116

GP0116 is an injectable, sterile, transparent product.

Intervention Type DEVICE

Active Comparator: FDA approved dermal filler device (RHA 3)

FDA approved dermal filler device (RHA 3)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Men and non-pregnant, non-breastfeeding women aged 22 years or older.
* WSRS grade of 3 or 4 (moderate to severe folds) on each NLF as assessed by the Blinded Evaluator. The WSRS for each NLF does not need to be equal.
* Intent to undergo treatment for correction of both left and right NLF.

Exclusion Criteria

* Known/previous allergy or hypersensitivity to any injectable hyaluronic acid (HA) gel
* Known/previous allergy or hypersensitivity to local anesthetics
* Previous or present severe or multiple allergies manifested by severe reactions
* Previous facial surgery near the treatment area
Minimum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Galderma R&D

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Galderma Investigational Site (Site#8074)

Santa Monica, California, United States

Site Status

Galderma Investigational Site (Site#8478)

Vista, California, United States

Site Status

Galderma Investigational Site (Site#8680)

Westport, Connecticut, United States

Site Status

Galderma Investigational Site (Site#8479)

Bradenton, Florida, United States

Site Status

Galderma Investigational Site (Site#7030)

Coral Gables, Florida, United States

Site Status

Galderma Investigational Site (Site#8284)

Coral Gables, Florida, United States

Site Status

Galderma Investigational Site (Site#8126)

West Palm Beach, Florida, United States

Site Status

Galderma Investigational Site (Site#7042)

Atlanta, Georgia, United States

Site Status

Galderma Investigational Site (Site#8580)

New Orleans, Louisiana, United States

Site Status

Galderma Investigational Site (Site#8481)

Chestnut Hill, Massachusetts, United States

Site Status

Galderma Investigational Site (Site#8631)

Birmingham, Michigan, United States

Site Status

Galderma Investigational Site (Site#8658)

New York, New York, United States

Site Status

Galderma Investigational Site (Site#8482)

Chapel Hill, North Carolina, United States

Site Status

Galderma Investigational Site (Site#8648)

Wilmington, North Carolina, United States

Site Status

Galderma Investigational Site (Site#8783)

Cincinnati, Ohio, United States

Site Status

Galderma Investigational Site (Site#8496)

Nashville, Tennessee, United States

Site Status

Galderma Investigational Site (Site#8662)

Spring, Texas, United States

Site Status

Galderma Investigational Site (Site#7047)

Arlington, Virginia, United States

Site Status

Galderma Investigational Site (Site#8784)

San Juan, , Puerto Rico

Site Status

Countries

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United States Puerto Rico

Other Identifiers

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43N3US2204

Identifier Type: -

Identifier Source: org_study_id

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