Clinical Study to Evaluate the Efficacy and Safety of Dermalax Implant Plus

NCT ID: NCT02179606

Last Updated: 2014-07-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-07-31

Brief Summary

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This study is to verify that Dermalax Implant Plus is not inferior to the reference device, Restylane® Sub-Q, in terms of efficacy and safety in the correction of nasolabial folds

Detailed Description

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Conditions

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Correction of Nasolabial Folds

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Dermalax Implant Plus

Subject injected in the nasolabial folds of one side of the face in the initial treatment period.

Group Type EXPERIMENTAL

Dermalax Implant Plus

Intervention Type DEVICE

Dermalax implant plus injection into one nasolabial fold(NFL) of one side of the face(blinded, split-face study design) in the initial treatment period.

Restylane Sub-Q

Intervention Type DEVICE

Restylane Sub-Q injection into one nasolabial fold(NFL) of one side of the face(blinded, split-face study design) in the initial treatment period.

Restylane Sub-Q

Subject injected in the nasolabial folds of one side of the face in the initial treatment period.

Group Type ACTIVE_COMPARATOR

Dermalax Implant Plus

Intervention Type DEVICE

Dermalax implant plus injection into one nasolabial fold(NFL) of one side of the face(blinded, split-face study design) in the initial treatment period.

Restylane Sub-Q

Intervention Type DEVICE

Restylane Sub-Q injection into one nasolabial fold(NFL) of one side of the face(blinded, split-face study design) in the initial treatment period.

Interventions

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Dermalax Implant Plus

Dermalax implant plus injection into one nasolabial fold(NFL) of one side of the face(blinded, split-face study design) in the initial treatment period.

Intervention Type DEVICE

Restylane Sub-Q

Restylane Sub-Q injection into one nasolabial fold(NFL) of one side of the face(blinded, split-face study design) in the initial treatment period.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Male or female subjects no younger than 30 and no more than 75 years of age.
2. Subjects who scored 3 or 4 on the Wrinkle Severity Rating Scale (WSRS) and want to improve the appearance of their nasolabial folds (the subject does not need to have the same score on both sides.\*)

\*The scores need not to be same on both sides, but the two nasolabial folds should have symmetry in the range of 3-4.
3. Subjects who have symmetric nasolabial folds.

Exclusion Criteria

1. Subjects who received an antithrombotic agent within 2 weeks prior to screening (with the exception of low dose Aspirin less than 300 mg/day)
2. Subjects who have a history of bleeding disorder.
3. Subjects who have received calcium hydroxyapatite, CaHA injection in nasolabial area.
Minimum Eligible Age

30 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Across Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Beom Joon Kim, MD

Role: PRINCIPAL_INVESTIGATOR

Chung-Ang University Hosptial, Chung-Ang University College of Medicine

Jong Hoon Lee, MD

Role: PRINCIPAL_INVESTIGATOR

Eulji General Hospital

Locations

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Chung-ang University Hospital

Seoul, , South Korea

Site Status

Eulji General Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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AC-13-01

Identifier Type: -

Identifier Source: org_study_id

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