Transcutaneous Tibial Nerve Stimulation for Idiopathic Overactive Bladder

NCT ID: NCT05977634

Last Updated: 2023-09-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

26 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-09-30

Study Completion Date

2026-08-30

Brief Summary

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This study was designed to assess the efficacy of trans cutaneous tibial nerve stimulation on symptoms of overactive bladder in women with idiopathic overactive bladder

Detailed Description

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Idiopathic overactive bladder is defined the presence of a sense of urgency with or without accompanying urinary incontinence without an organic pathology or urinary infection. Its prevalence was reported to be between 7.7 to 31 % in women. In this prospective randomized controlled study, we aim to assess the efficacy of trans cutaneous tibial nerve stimulation on symptoms of overactive bladder in women with idiopathic overactive bladder.

Conditions

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Overactive Bladder Overactive Bladder Syndrome Overactive Detrusor

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Investigators Outcome Assessors
Outcome assessor and investigator that assesses the patients will be blind to the study groups

Study Groups

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Transcutaneous tibial nerve stimulation plus bladder training

Patients will receive transcutaneous tibial nerve stimulation for 30 minutes, twice a week, for 6 weeks. Application will be done in an outpatient setting, using disposable surface electrodes.

Group Type EXPERIMENTAL

Bladder training

Intervention Type BEHAVIORAL

Bladder training has 4 components, educating the patient about anatomy, fluid intake control, pelvic floor muscle contractions and increasing the interval between visits to the bathroom

Transcutaneous tibial nerve stimulation

Intervention Type DEVICE

A combined electrotherapy device capable of applying transcutaneous electrical nerve stimulation will be used. Each session will take 30 minutes. Patient will visit the hospital twice a week for 6 weeks. An electrical current of 0-50 amperes with a frequency of 20 herz, and a duration of 200 micro seconds will be applied using 50x50 mm surface electordes. The aim is to create a tingling sensation without causing any pain on the tibial nerve, at the ankle level.

Bladder training

patients will receive only the routine education program that is given to every patient with idiopathic overactive bladder syndrome. This includes education about the anatomy of the urinary system, patient motivation, and frequent bathroom visits in order to avoid incontinence with gradual increase between each visit to the bathroom.

Group Type OTHER

Bladder training

Intervention Type BEHAVIORAL

Bladder training has 4 components, educating the patient about anatomy, fluid intake control, pelvic floor muscle contractions and increasing the interval between visits to the bathroom

Interventions

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Bladder training

Bladder training has 4 components, educating the patient about anatomy, fluid intake control, pelvic floor muscle contractions and increasing the interval between visits to the bathroom

Intervention Type BEHAVIORAL

Transcutaneous tibial nerve stimulation

A combined electrotherapy device capable of applying transcutaneous electrical nerve stimulation will be used. Each session will take 30 minutes. Patient will visit the hospital twice a week for 6 weeks. An electrical current of 0-50 amperes with a frequency of 20 herz, and a duration of 200 micro seconds will be applied using 50x50 mm surface electordes. The aim is to create a tingling sensation without causing any pain on the tibial nerve, at the ankle level.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Overactive Bladder Questionnaire Validation Study questionnaire 8 scores higher than 11.
* Post voiding residue levels less than 100 ml.
* Women aged between 18-70

Exclusion Criteria

* Prior history of pelvic surgery
* Pelvic organ prolapsus of grade 2 or more.
* Current urinary tract infection
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Ege University

OTHER

Sponsor Role lead

Responsible Party

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Ece Cinar

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ece Cinar, MD

Role: PRINCIPAL_INVESTIGATOR

Ege University School of Medicine

Locations

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Ege University School of Medicine

Bornova, İzmir, Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Central Contacts

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Ece Cinar, MD

Role: CONTACT

00905372257018

Yesim Akkoc, MD

Role: CONTACT

00902323903690

Facility Contacts

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Ece Cinar, MD

Role: primary

005372257018

Yesim Akkoc, MD

Role: backup

00902323903690

References

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Bo K, Frawley HC, Haylen BT, Abramov Y, Almeida FG, Berghmans B, Bortolini M, Dumoulin C, Gomes M, McClurg D, Meijlink J, Shelly E, Trabuco E, Walker C, Wells A. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for the conservative and nonpharmacological management of female pelvic floor dysfunction. Int Urogynecol J. 2017 Feb;28(2):191-213. doi: 10.1007/s00192-016-3123-4. Epub 2016 Dec 5.

Reference Type BACKGROUND
PMID: 27921161 (View on PubMed)

Ramirez-Garcia I, Blanco-Ratto L, Kauffmann S, Carralero-Martinez A, Sanchez E. Efficacy of transcutaneous stimulation of the posterior tibial nerve compared to percutaneous stimulation in idiopathic overactive bladder syndrome: Randomized control trial. Neurourol Urodyn. 2019 Jan;38(1):261-268. doi: 10.1002/nau.23843. Epub 2018 Oct 12.

Reference Type BACKGROUND
PMID: 30311692 (View on PubMed)

Gormley EA, Lightner DJ, Faraday M, Vasavada SP; American Urological Association; Society of Urodynamics, Female Pelvic Medicine. Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline amendment. J Urol. 2015 May;193(5):1572-80. doi: 10.1016/j.juro.2015.01.087. Epub 2015 Jan 23.

Reference Type BACKGROUND
PMID: 25623739 (View on PubMed)

Other Identifiers

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Ege 19-12.3/5

Identifier Type: -

Identifier Source: org_study_id

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