Effects of Subconscious Memory Extinction in Patients With Alcohol Dependence and Its Mechanism
NCT ID: NCT05942521
Last Updated: 2023-10-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
90 participants
INTERVENTIONAL
2023-07-20
2024-12-31
Brief Summary
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1. Whether subconscious extinction intervention would reduce psychological craving and alcohol relapse?
2. What is the mechanism of subconscious extinction intervention in alcohol dependence?
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Very brief extinction
Enrolled participants would receive very brief extinction approximately 25 minutes per day for 2 days.
Very brief extinction
The very brief extinction presents a very short (33ms) repetitive sequence of alcohol cues, followed by a "masking" stimulus(117ms), which masks the alcohol cues. In the case of repeated exposure to alcohol stimulation, the response to the stimulation is desensitized at the level of unconscious processing.
Very brief neutral extinction
Enrolled participants would receive very brief neutral extinction for approximately 25 minutes per day for 2 days.
Very brief neutral extinction
The very brief neutral extinction presents a very short (33ms) repetitive sequence of neutral cues, followed by a "masking" stimulus(117ms), which masks the neutral cues. In the case of repeated exposure to neutral stimulation, the response to the stimulation is desensitized at the level of unconscious processing.
Clearly visible extinction
Enrolled participants would receive clearly visible extinction therapy for approximately 25 minutes per day for 2 days.
Clearly visible extinction
The clearly visible extinction presents a repetitive sequence of alcohol cues(150ms) without a "masking" stimulus. In the case of repeat exposure to alcohol stimulation, the response to the stimulation is desensitized at the level of conscious processing.
Interventions
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Very brief extinction
The very brief extinction presents a very short (33ms) repetitive sequence of alcohol cues, followed by a "masking" stimulus(117ms), which masks the alcohol cues. In the case of repeated exposure to alcohol stimulation, the response to the stimulation is desensitized at the level of unconscious processing.
Clearly visible extinction
The clearly visible extinction presents a repetitive sequence of alcohol cues(150ms) without a "masking" stimulus. In the case of repeat exposure to alcohol stimulation, the response to the stimulation is desensitized at the level of conscious processing.
Very brief neutral extinction
The very brief neutral extinction presents a very short (33ms) repetitive sequence of neutral cues, followed by a "masking" stimulus(117ms), which masks the neutral cues. In the case of repeated exposure to neutral stimulation, the response to the stimulation is desensitized at the level of unconscious processing.
Eligibility Criteria
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Inclusion Criteria
2. Complete detoxification treatment without obvious withdrawal symptoms;
3. Informed consent, voluntary participation.
Exclusion Criteria
2. Patients who meet the DSM-Ⅳ diagnosis of psychoactive substances or non-psychoactive substances other than alcohol (except nicotine);
3. Previous acceptance experienced similar exposure therapy;
18 Years
60 Years
ALL
No
Sponsors
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Shenzhen Kangning Hospital
OTHER
Responsible Party
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Xiaojian Jia
Professor
Principal Investigators
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Xiaojian Jia
Role: PRINCIPAL_INVESTIGATOR
Shenzhen Kangning Hospita
Locations
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Shenzhen Kangning Hospital
Shenzhen, Guangdong, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2022-K013-01
Identifier Type: -
Identifier Source: org_study_id
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