Long-term Success Rate of Transvaginal Mesh for the Treatment of Pelvic Organ Prolapse: The Extended RCT Study

NCT ID: NCT05938881

Last Updated: 2023-07-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

336 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-06-29

Study Completion Date

2033-03-12

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The original RCT trial is designed to compare self-tailored titanium-coated polypropylene mesh procedure with mesh-kit in the treatment of POP stage III-IV in terms of efficacy, safety and cost-effective at 1-year follow-up. This study will follow women in the original RCT study for up to 10 years from the time of the surgery to compare success and complication rates in the two groups. Recruitment into this study is open only to women that already participated in previous RCT, no new treatment interventions will be given. Recruitment into the previous RCT is closed. Women will be strongly encouraged to participate in annual examinations and annual telephone surveys but may participate in only one of these study parts if needed.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The previous study is a randomized trial designed to compare the composite success rate between patients with self-cut mesh procedure and those with mesh-kit procedure. The original RCT study includes a 1-year follow up from the time of surgery, which is too short to evaluate the long-term sequelae of the surgical procedures. The goal of this long-term follow-up study is to extend the follow-up of women in the previous RCT study up to 10 years from the time of surgery and to compare the success and complication rates of the two surgical treatment groups over this extended time period.

The primary aim is to determine whether treatment success in women who undergo the above strategies differ at time points through 10 years. A supplemental study investigates the long-term success rate and complications of transvaginal mesh procedure in women in both of the study arms.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pelvic Organ Prolapse

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

self-cut mesh procedure

This procedure is transvaginal mesh implantation surgery for POP patients. Self-cut mesh procedure is an economic pelvic reconstructive surgical operation with use of specially designed puncture needles and self-cut mesh, which mainly provide anterior and apical compartments support, with posterior compartment reinforced by bridge technique repair. The mesh pieces used in this surgery was cut from a single piece of mesh material(TiLOOP 10\*15cm) which is much cheaper and readily available. Patients could have transvaginal hysterectomy concomitantly.

self-cut mesh procedure

Intervention Type PROCEDURE

transvaginal mesh procedure using self-cut mesh

mesh-kit procedure

This procedure is transvaginal mesh implantation surgery for POP patients.Mesh-kit procedure is refered to pelvic floor reconstructive surgery with titanium-coated meshes kit(TiLOOP TOTAL6).Patients could have transvaginal hysterectomy concomitantly.

mesh-kit procedure

Intervention Type PROCEDURE

transvaginal mesh procedure using mesh-kit

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

self-cut mesh procedure

transvaginal mesh procedure using self-cut mesh

Intervention Type PROCEDURE

mesh-kit procedure

transvaginal mesh procedure using mesh-kit

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Women enrolled in previous RCT study

Exclusion Criteria

* Inability to provide informed consent. Informed consent will be obtained prior to each telephone interview and each in-person visit.
* Subjects who appear to have cognitive deficits during the in-person visit or site telephone interview will be withdrawn from the study by the study coordinator.
Minimum Eligible Age

53 Years

Maximum Eligible Age

75 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Peking Union Medical College Hospital

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Lan Zhu

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Foshan Maternal and Child Health Care Hospital

Foshan, Guangdong, China

Site Status RECRUITING

The First Affiliated Hospital of Guangdong Medical College

Guangzhou, Guangdong, China

Site Status RECRUITING

Changsha Maternal and Child Health Care Hospital

Changsha, Hunan, China

Site Status RECRUITING

The Secong Xiangya Hospital of Central South University

Changsha, Hunan, China

Site Status RECRUITING

Wuxi Maternal and Child Health Care Hospital

Wuxi, Jiangsu, China

Site Status RECRUITING

Qilu Hospital of Shandong University

Jinan, Shandong, China

Site Status RECRUITING

Shanxi Provincial People's Hosptial

Xi’an, Shanxi, China

Site Status RECRUITING

Sichuan University West China Second University Hospital

Chengdu, Sichuan, China

Site Status RECRUITING

the First Affiliated Hosptial of Xinjiang Medical University

Ürümqi, Xiangjiang, China

Site Status RECRUITING

The People's Hospital of Xinjiang Uygur Autonomous Region

Ürümqi, Xinjiang, China

Site Status RECRUITING

Peking Union Medical College Hospital

Beijing, , China

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

China

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Lan Zhu

Role: CONTACT

86-10-69155749

Juan Chen

Role: CONTACT

86-10-69155749

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Yuling Wang

Role: primary

Xiaowei Zhang

Role: primary

Binan Wang

Role: primary

Guangshi Tao

Role: primary

Jian Gong

Role: primary

Peishu Liu

Role: primary

Xiangyang Jiang

Role: primary

Ping Wang

Role: primary

Gulina Ababaikeli

Role: primary

Hatiguli Nisier

Role: primary

Juan Chen

Role: primary

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

extended TVM

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.