Smartmesh Technology in Pelvic Floor Repair Procedures

NCT ID: NCT03098641

Last Updated: 2023-11-13

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

272 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-05-01

Study Completion Date

2017-09-26

Brief Summary

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Pelvic organ prolapse repair involves conservative treatments and surgical treatments. Conservative treatments are for patients with moderate prolapse. Treatment of symptomatic prolapse remains essentially surgical. According to detailed medical history and a thorough physical exam, surgical techniques may be performed by high abdominal, low vaginal or mixed routes with or without the use of a reinforcing implant. Restorelle Direct Fix is indicated for transvaginal anterior and posterior surgical repair either as mechanical support or as reinforcement of pelvic floor defects. Advantages and disadvantages of vaginal prostheses are known but only limited data have been reported on the use of Restorelle® in the treatment of pelvic organ prolapse. This study is designed to collect data on the safety and efficacy of Restorelle® Direct Fix in pelvic organ prolapse repair.

Detailed Description

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Between January 2013 and December 2016, in the participating centers, all adult women who underwent surgery to repair pelvic organ prolapse (recurrent or not) through the vagina with the addition of anterior and/or posterior Restorelle Direct Fix prosthesis are eligible. Collected data are about the peri-operative period and the data available at the last consultation.

Conditions

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Pelvic Organ Prolapse

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Interventions

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pelvic organ prolapse repair

Surgery to repair pelvic organ prolapse through the vagina using stitches with the addition of surgical mesh.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Over 18
* woman who underwent surgery to repair pelvic organ prolapse (recurrent or not) through the vagina with the addition of anterior and/or posterior Restorelle Direct Fix prosthesis
* informed and not opposed to the use of her data

Exclusion Criteria

* Opposed to the use of her data
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Coloplast A/S

INDUSTRY

Sponsor Role collaborator

Groupe Hospitalier de la Rochelle Ré Aunis

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Philippe Ferry, MD

Role: STUDY_DIRECTOR

Groupe Hospitalier de la Rochelle Ré Aunis

Locations

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CH Dunkerque

Grande-Synthe, , France

Site Status

Groupe Hospitalier de la Rochelle Ré Aunis

La Rochelle, , France

Site Status

Clinique Saint Ame

Lambres-lez-Douai, , France

Site Status

CH de Laon

Laon, , France

Site Status

Clinique Jules Verne

Nantes, , France

Site Status

CHU Nîmes

Nîmes, , France

Site Status

Hôpital des Diaconesses

Paris, , France

Site Status

Hôpital Kremlin-Bicêtre

Paris, , France

Site Status

CH de Cornouaille

Quimper, , France

Site Status

Clinique St Michel et St Anne

Quimper, , France

Site Status

Polyclinique de Courlancy

Reims, , France

Site Status

Clinique la Sagesse

Rennes, , France

Site Status

CH Robert Pax

Sarreguemines, , France

Site Status

Agyl

Strasbourg, , France

Site Status

Hôpital Foch

Suresnes, , France

Site Status

Hôpitaux du Léman

Thonon-les-Bains, , France

Site Status

Countries

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France

References

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Le Normand L, Cosson M, Cour F, Deffieux X, Donon L, Ferry P, Fatton B, Hermieu JF, Marret H, Meurette G, Cortesse A, Wagner L, Fritel X. [Clinical practice guidelines: Summary of recommendations for first surgical treatment of female pelvic organ prolapse by 5 French academic societies: AFU, CNGOF, SIFUD-PP, SNFCP, and SCGP]. Prog Urol. 2016 Jul;26 Suppl 1:S1-7. doi: 10.1016/S1166-7087(16)30424-9. French.

Reference Type BACKGROUND
PMID: 27595623 (View on PubMed)

Khunda A, Vashisht A, Cutner A. New procedures for uterine prolapse. Best Pract Res Clin Obstet Gynaecol. 2013 Jun;27(3):363-79. doi: 10.1016/j.bpobgyn.2012.12.004. Epub 2013 Jan 5.

Reference Type BACKGROUND
PMID: 23298608 (View on PubMed)

Olsen AL, Smith VJ, Bergstrom JO, Colling JC, Clark AL. Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. Obstet Gynecol. 1997 Apr;89(4):501-6. doi: 10.1016/S0029-7844(97)00058-6.

Reference Type BACKGROUND
PMID: 9083302 (View on PubMed)

Nygaard I, Barber MD, Burgio KL, Kenton K, Meikle S, Schaffer J, Spino C, Whitehead WE, Wu J, Brody DJ; Pelvic Floor Disorders Network. Prevalence of symptomatic pelvic floor disorders in US women. JAMA. 2008 Sep 17;300(11):1311-6. doi: 10.1001/jama.300.11.1311.

Reference Type BACKGROUND
PMID: 18799443 (View on PubMed)

Persu C, Chapple CR, Cauni V, Gutue S, Geavlete P. Pelvic Organ Prolapse Quantification System (POP-Q) - a new era in pelvic prolapse staging. J Med Life. 2011 Jan-Mar;4(1):75-81. Epub 2011 Feb 25.

Reference Type BACKGROUND
PMID: 21505577 (View on PubMed)

Lousquy R, Costa P, Delmas V, Haab F. [Update on the epidemiology of genital prolapse]. Prog Urol. 2009 Dec;19(13):907-15. doi: 10.1016/j.purol.2009.09.011. Epub 2009 Nov 4. French.

Reference Type BACKGROUND
PMID: 19969258 (View on PubMed)

Maher C, Feiner B, Baessler K, Christmann-Schmid C, Haya N, Marjoribanks J. Transvaginal mesh or grafts compared with native tissue repair for vaginal prolapse. Cochrane Database Syst Rev. 2016 Feb 9;2(2):CD012079. doi: 10.1002/14651858.CD012079.

Reference Type BACKGROUND
PMID: 26858090 (View on PubMed)

Ferry P, Bertherat P, Gauthier A, Villet R, Del Piano F, Hamid D, Fernandez H, Broux PL, Salet-Lizee D, Vincens E, Ntshaykolo P, Debodinance P, Pocholle P, Thirouard Y, de Tayrac R. Transvaginal treatment of anterior and apical genital prolapses using an Ultra lightweight mesh: Restorelle(R) Direct Fix. A retrospective study on feasibility and morbidity. J Gynecol Obstet Hum Reprod. 2018 Nov;47(9):443-449. doi: 10.1016/j.jogoh.2018.06.001. Epub 2018 Jun 18.

Reference Type RESULT
PMID: 29920380 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Related Links

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http://www.afnor.org/

Association Française de Normalisation (AFNOR). Norme Française (NF) S 94-801 implants de renfort mis en place par voie vaginale pour cure d'incontinence urinaire d'effort et/ou de prolapsus des organes pelviens. Essais pré-cliniques et essais cliniques

Other Identifiers

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2016/P05/179

Identifier Type: -

Identifier Source: org_study_id

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