UGYTEX® Mesh Versus Subvesical Plication in the Surgical Treatment of Bladder Prolapse

NCT ID: NCT02255994

Last Updated: 2025-11-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

75 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-10-31

Study Completion Date

2015-12-07

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The main purpose of this study is to evaluate the long-term (5-8 years) functional prolapse recurrence rate of the 147 patients enrolled, randomized and analyzed in the study PRO-CURE I.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Secondary objectives include comparing the following elements between the two randomized groups at a long-term time point (5-8 years):

A. The anatomic failure rate of cystocele (POP-Q stage \> or = 2) B. Late postoperative morbidity C. Residual post-operative pain (visual analog scale (VAS)) D. Patient satisfaction via the PGI-I questionnaire E. Quality of life via the PFDI and PFIQ questionnaires F. Sexual activity via the PISQ-12 questionnaire G. The rate of vaginal erosion H. Displacement and secondary shrinkage of meshs

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cystocele

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

UGYTEX

Patients in this arm received the UGYTEX mesh in the pro-cure 1 study (see NCT00153257)

Group Type EXPERIMENTAL

UGYTEX

Intervention Type DEVICE

Patients in this arm received the UGYTEX mesh in the pro-cure 1 study (see NCT00153257)

No MESH

Patients in this arm had subvesical plication without reinforcement.

Group Type ACTIVE_COMPARATOR

No mesh.

Intervention Type PROCEDURE

Patients in this arm had subvesical plication without reinforcement.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

UGYTEX

Patients in this arm received the UGYTEX mesh in the pro-cure 1 study (see NCT00153257)

Intervention Type DEVICE

No mesh.

Patients in this arm had subvesical plication without reinforcement.

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* The patient must have given her informed and signed consent
* The patient must be insured or beneficiary of a health insurance plan
* Patient included in, randomized and analysed in the PROCURE study (NCT00153257)

Exclusion Criteria

* The patient is under judicial protection, under tutorship or curatorship
* The patient refuses to sign the consent
* It is impossible to correctly inform the patient
* Patient not included in the PROCURE study
Minimum Eligible Age

60 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Centre Hospitalier Universitaire de Nīmes

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Renaud de Tayrac, MD, PhD

Role: STUDY_DIRECTOR

Centre Hospitalier Universitaire de Nîmes

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Clinique Champeau

Béziers, , France

Site Status

APHP - Hôpital Antoine Beclere

Clamart, , France

Site Status

CHU de Clermont Ferrand - Hôpital Estaing

Clermont-Ferrand, , France

Site Status

APHP - Hôpital Beaujon

Clichy, , France

Site Status

CH d'Issoire - Centre Hospitalier Paul Ardier

Issoire, , France

Site Status

CH de la Rochelle

La Rochelle, , France

Site Status

CH de Chartres - Hôpital Louis Pasteur

Le Coudray, , France

Site Status

APHP - Centre Hospitalier Universitaire de Bicêtre

Le Kremlin-Bicêtre, , France

Site Status

CHRU de Nîmes - Hôpital Universitaire Carémeau

Nîmes, , France

Site Status

CH d'Orange - Hôpital Louis Giorgi

Orange, , France

Site Status

Clinique Mutualiste La Sagesse

Rennes, , France

Site Status

CHU de Rouen - Hôpital Charles Nicolle

Rouen, , France

Site Status

Countries

Review the countries where the study has at least one active or historical site.

France

References

Explore related publications, articles, or registry entries linked to this study.

Allegre L, Callewaert G, Alonso S, Cornille A, Fernandez H, Eglin G, de Tayrac R. Long-term outcomes of a randomized controlled trial comparing trans-obturator vaginal mesh with native tissue repair in the treatment of anterior vaginal wall prolapse. Int Urogynecol J. 2020 Apr;31(4):745-753. doi: 10.1007/s00192-019-04073-x. Epub 2019 Sep 10.

Reference Type RESULT
PMID: 31506808 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2013-A01705-40

Identifier Type: OTHER

Identifier Source: secondary_id

LOCAL/2013/RdeT-01

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.