Evaluating Bronchodilator Response in Patients With Bronchiectasis

NCT ID: NCT05932316

Last Updated: 2023-07-06

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 96 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-05-20
• Study Completion Date: 2024-12-31

Brief Summary

Although patients with bronchiectasis tend to have non reversible obstructive patterns on pulmonary function tests (PFTs), reversible obstruction is not uncommon. While bronchodilator response (BDR) is a main characteristic of asthma, the pathophysiology causing this phenomenon in bronchiectasis patients is less clear.

The goal of this clinical trial is to assess BDR in patients with bronchiectasis.

The main aims of this study:

1. To evaluate the role of bronchodilators in BDR testing of patients with bronchiectasis.

2. Characterize and compare BDR between different subgroups of patients with bronchiectasis, and compared to patients without bronchiectasis (healthy controls).

3. Identify demographics and other clinical variables associated with positive BDR

Participants will be taking a series of three spirometry tests: After the first spirometry testing, patients will be randomly assigned to receive bronchodilators as per bronchodilator response protocol (Salbutamol, 100 mcg, 4 puffs via spacer) or four puffs of placebo. After a waiting time of 15 minutes, spirometry will be repeated. Following the second spirometry testing those who received salbutamol will now receive placebo and those receiving placebo will receive Salbutamol. After a second period of 15 minutes, a third series of spirometry will be recorded.

Detailed Description

Bronchiectasis are defined as irreversible dilatation of the bronchial tree. Patients with bronchiectasis suffer of chronic cough and sputum production, and are predisposed to recurrent airway infections. Many systemic diseases can cause bronchiectasis: cystic fibrosis (CF), primary ciliary dyskinesia (PCD), primary immune deficiencies (PID) and idiopathic bronchiectasis (IB) represent a significant proportion of patients with bronchiectasis starting in early age.

Pulmonary function testing (PFT) and specifically forced expiratory volume in one second (FEV1) is a common modality used to estimate lung disease progression and pulmonary exacerbations in patients with bronchiectasis. Although patients with bronchiectasis tend to have non reversible obstructive patterns on pulmonary function tests (PFTs), reversible obstruction is not uncommon. While bronchodilator response (BDR) is a main characteristic of asthma, the pathophysiology causing this phenomenon in bronchiectasis patients is less clear. The improvement in FEV1 after inhalation of bronchodilators can be attributed to bronchodilation or improved mucociliary clearance. It can be speculated that for some of the bronchiectasis patients, hyper-reactive airways or asthma can contribute to the reversible pattern. Despite the wide scale use of bronchodilators in bronchiectasis the evidence for its efficacy is lacking. While some studies found that BDR is associated with more severe disease, other studies did not find such associations.

According to ATS/ERS statement, the proper way to determine BDR, is by first recording three attempts of spirometry, then delivering bronchodilators, and after a waiting time, obtaining again at least three attempts of spirometry. The most resent ATS/ERS technical standard suggests that change of >10% relative to the predicted value for FEV1 or forced vital capacity (FVC) be considered a positive BDR.

While in most scenarios it is reasonable to assume that the change in FEV1 measured after the waiting time can be attributed solely to the affect of bronchodilators, this is not necessarily the case in bronchiectatic diseases. Theoretically, in bronchiectasis, the forced expiration maneuver used in spirometry testing can potentially cause changes in lung function, for example by inducing cough and mobilization of sputum. Evidence for this assumption can be seen in that respiratory therapy in terms if positive expiratory pressure (PEP) therapy can improve various parameters of lung function when tested again closely after the therapy.

The goal of this study is to determine if bronchodilator response in bronchiectatic disease might be influenced by other factors apart from the direct effect of bronchodilators. Secondary objectives are to assess if BDR is associated with age, gender, specific bronchiectatic disease, baseline FEV1, and other clinical factors such as sputum cultures, IgE levels, eosinophil levels, computed tomography (CT) score, family history of asthma and use of inhaled steroids.

Conditions

Bronchiectasis; Cystic Fibrosis; Primary Ciliary Dyskinesia; Primary Immune Deficiency; Bronchiolitis Obliterans

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: TRIPLE

Study Groups

Salbutamol first

Individuals included in this arm will receive 4 puffs of Salbutamol prior to the second set of spirometry testing, and 4 puffs of Placebo prior to the third set of spirometry.

Group Type: OTHER

spirometry

Intervention Type: DIAGNOSTIC_TEST

participants will undertake spirometry testing before and after bronchodilators and placebo

Salbutamol

Intervention Type: DRUG

Salbutamol inhalation to determine bronchodilator response

placebo

Intervention Type: DRUG

placebo inhalation prior to repeating spirometry

Placebo First

Individuals included in this arm will receive 4 puffs of placebo prior to the second set of spirometry testing and 4 puffs of Salbutamol prior to the third set of spirometry testing.

Group Type: OTHER

spirometry

Intervention Type: DIAGNOSTIC_TEST

participants will undertake spirometry testing before and after bronchodilators and placebo

Salbutamol

Intervention Type: DRUG

Salbutamol inhalation to determine bronchodilator response

placebo

Intervention Type: DRUG

placebo inhalation prior to repeating spirometry

Interventions

spirometry

participants will undertake spirometry testing before and after bronchodilators and placebo

Intervention Type: DIAGNOSTIC_TEST

Salbutamol

Salbutamol inhalation to determine bronchodilator response

Intervention Type: DRUG

placebo

placebo inhalation prior to repeating spirometry

Intervention Type: DRUG

Other Intervention Names

pulmonary function testing; bronchodilator

Eligibility Criteria

Inclusion Criteria

• Patients with bronchiectasis confirmed by CT scan
• No recent pulmonary exacerbation as determined by prescription of systemic antibiotics in 7 days prior to BDR testing
• No use of long-acting beta agonists (LABA) 12 hours before BDR testing or short acting beta agonist (SABA) 4 hours before testing

Exclusion Criteria

• Patients under 5 years of age
• Patients incapable to perform proper spirometry

• Minimum Eligible Age: 5 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Rambam Health Care Campus

OTHER

Sponsor Role: lead

Responsible Party

Mordechai Pollak MD, MSc

Dr Mordechai Pollak

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Mordechai Pollak, MD, MSc

Role: PRINCIPAL_INVESTIGATOR

pediatric pulmonology institute, Ruth Rappaport children's hospital, Rambam medical center

Locations

Rambam Health Campus

Haifa, , Israel

Site Status: RECRUITING

Countries

Israel

Central Contacts

Mordechai Pollak, MD, MSc

Role: CONTACT

m_pollak@rambam.health.gov.il

+972542388651

Facility Contacts

Mordechai Pollak, MD, MSc

Role: primary

morduchp@gmail.com

0542388651

Other Identifiers

0025-23-RMB

Identifier Type: -

Identifier Source: org_study_id