Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
NA
50 participants
INTERVENTIONAL
2024-06-01
2029-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
DOUBLE
Study Groups
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Placebo
Placebo given that mimics taste, weight, and size of the interventional supplement mirroring the same time points as the ketone ester supplement group. Mirrored imaging with MRI as well.
Placebo
Added to water or lemonade 3 times per day.
Ketone ester supplement
Ketone ester given daily for 12 weeks and scanned before and after intervention with MRI.
Ketone Ester
Added to water or lemonade 3 times per day.
Interventions
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Ketone Ester
Added to water or lemonade 3 times per day.
Placebo
Added to water or lemonade 3 times per day.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Contraindicated implanted device
18 Years
ALL
No
Sponsors
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The Cleveland Clinic
OTHER
Responsible Party
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Christopher Nguyen
Director
Locations
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Cardiovascular Innovation Research Center
Cleveland, Ohio, United States
Countries
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References
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Yurista SR, Matsuura TR, Sillje HHW, Nijholt KT, McDaid KS, Shewale SV, Leone TC, Newman JC, Verdin E, van Veldhuisen DJ, de Boer RA, Kelly DP, Westenbrink BD. Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure. Circ Heart Fail. 2021 Jan;14(1):e007684. doi: 10.1161/CIRCHEARTFAILURE.120.007684. Epub 2020 Dec 28.
Yurista SR, Eder RA, Welsh A, Jiang W, Chen S, Foster AN, Mauskapf A, Tang WHW, Hucker WJ, Coll-Font J, Rosenzweig A, Nguyen CT. Ketone ester supplementation suppresses cardiac inflammation and improves cardiac energetics in a swine model of acute myocardial infarction. Metabolism. 2023 Aug;145:155608. doi: 10.1016/j.metabol.2023.155608. Epub 2023 Jun 1.
Other Identifiers
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23-570
Identifier Type: -
Identifier Source: org_study_id
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