Acute Oral Ketones or Carbohydrate Supplement Modify Heart Function in Heart Failure?
NCT ID: NCT05651529
Last Updated: 2022-12-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
20 participants
INTERVENTIONAL
2022-12-16
2024-12-16
Brief Summary
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Detailed Description
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Participants will have 2 different cardiac MRI to perform:
1. Fasting with exogenous ketone salt supplement
2. Fasting with exogenous carbohydrate supplement
Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
TRIPLE
Interventions
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exogenous ketone salt supplement
Dietary Supplement: Fasting water and with exogenous ketone salt supplement. Participants will have to take 1 doses of supplement 30 minutes before the scan.
exogenous carbohydrate supplement
Dietary Supplement: Fasting water and with exogenous carbohydrate supplement. Participants will have to take 1 doses of supplement 30 minutes before the scan.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Heart failure of ischemic or dilated etiology
* Ambulatory patient with a NYHA functional class of II-III;
* Stable symptoms and no change in medical therapy in the last month.
Exclusion Criteria
* Patients treated with any SGLT2i;
* Chronic kidney disease
* Acute coronary syndrome in the last 3 months;
* Use of parenteral inotropic agents;
* Persistent or permanent atrial fibrillation or atrial flutter;
* Presence of pacemaker or defibrillator;
* Medical condition that causes malabsorption of the test material;
* Under ketogenic diet, or using exogenous ketone supplements
* Use of nicotinamide adenine dinucleotide (NAD) precursor supplements
18 Years
ALL
No
Sponsors
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Nestlé Health Science Spain
INDUSTRY
Université de Sherbrooke
OTHER
Responsible Party
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Locations
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Centre Hospitalier Universitaire de Sherbrooke, departement de cardiologie
Sherbrooke, Quebec, Canada
Centre Hospitalier Universitaire de Sherbrooke, departement de médecine
Sherbrooke, Quebec, Canada
Countries
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Other Identifiers
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2023-4720
Identifier Type: -
Identifier Source: org_study_id