Automated Imaging Differentiation of Parkinsonism

NCT ID: NCT05913687

Last Updated: 2026-01-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

315 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-07-22

Study Completion Date

2026-03-31

Brief Summary

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The purpose of this study is to test the performance of the AID-P across 21 sites in the Parkinson Study Group. Each site will perform imaging, clinical scales, diagnosis, and will upload the data to the web-based software tool. The clinical diagnosis will be blinded to the diagnostic algorithm and the imaging diagnosis will be compared to the movement disorders trained neurologist diagnosis.

Detailed Description

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Conditions

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Parkinson Disease Multiple System Atrophy, Parkinson Variant Progressive Supranuclear Palsy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Parkinson's disease

Clinically diagnosed Parkinson's disease

AIDP

Intervention Type DIAGNOSTIC_TEST

Machine learning algorithm of imaging data

Multiple System Atrophy, Parkinsonian variant

Clinically diagnosed Multiple System Atrophy, Parkinsonian variant

AIDP

Intervention Type DIAGNOSTIC_TEST

Machine learning algorithm of imaging data

Progressive Supranuclear Palsy

Clinically diagnosed Progressive Supranuclear Palsy

AIDP

Intervention Type DIAGNOSTIC_TEST

Machine learning algorithm of imaging data

Interventions

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AIDP

Machine learning algorithm of imaging data

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Parkinson's disease diagnosis within 5-9 years of baseline date
* MSAp diagnosis
* PSP diagnosis

Exclusion Criteria

* metal implants in the body that preclude an MRI (pacemaker, metallic clip, neurostimulator, etc)
* claustrophobia
* pregnancy
Minimum Eligible Age

40 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Augusta University

OTHER

Sponsor Role collaborator

Albany Medical College

OTHER

Sponsor Role collaborator

Beth Israel Deaconess Medical Center

OTHER

Sponsor Role collaborator

Duke University

OTHER

Sponsor Role collaborator

Johns Hopkins University

OTHER

Sponsor Role collaborator

Massachusetts General Hospital

OTHER

Sponsor Role collaborator

Northwestern University

OTHER

Sponsor Role collaborator

Ottawa Hospital Research Institute

OTHER

Sponsor Role collaborator

Penn State University

OTHER

Sponsor Role collaborator

University of Alabama at Birmingham

OTHER

Sponsor Role collaborator

University of California, San Diego

OTHER

Sponsor Role collaborator

University of California, San Francisco

OTHER

Sponsor Role collaborator

University of Chicago

OTHER

Sponsor Role collaborator

University of Michigan

OTHER

Sponsor Role collaborator

University of Minnesota

OTHER

Sponsor Role collaborator

University of South Florida

OTHER

Sponsor Role collaborator

Centre for Addiction and Mental Health

OTHER

Sponsor Role collaborator

Wake Forest University

OTHER

Sponsor Role collaborator

Washington University School of Medicine

OTHER

Sponsor Role collaborator

University of Kentucky

OTHER

Sponsor Role collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

Sponsor Role collaborator

University of Florida

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status

University of California San Diego

La Jolla, California, United States

Site Status

University of California San Francisco

San Francisco, California, United States

Site Status

University of Florida

Gainesville, Florida, United States

Site Status

University of South Florida

Tampa, Florida, United States

Site Status

Augusta University

Augusta, Georgia, United States

Site Status

Northwestern University

Chicago, Illinois, United States

Site Status

University of Chicago

Chicago, Illinois, United States

Site Status

University of Kentucky

Lexington, Kentucky, United States

Site Status

Johns Hopkins University

Lutherville, Maryland, United States

Site Status

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

Site Status

Massachusetts General Hospital

Charlestown, Massachusetts, United States

Site Status

University of Michigan

Ann Arbor, Michigan, United States

Site Status

University of Minnesota

Minneapolis, Minnesota, United States

Site Status

Washington University in St. Louis

St Louis, Missouri, United States

Site Status

Albany Medical College

Albany, New York, United States

Site Status

Duke University Medical Center

Durham, North Carolina, United States

Site Status

Wake Forest University

Winston-Salem, North Carolina, United States

Site Status

Pennsylvania State University

Hershey, Pennsylvania, United States

Site Status

Ottawa Hospital Research Institute

Ottawa, , Canada

Site Status

Centre for Addiction and Mental Health

Toronto, , Canada

Site Status

Countries

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United States Canada

Other Identifiers

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PRO00028349

Identifier Type: OTHER

Identifier Source: secondary_id

5U01NS119562

Identifier Type: NIH

Identifier Source: secondary_id

View Link

IRB202002350

Identifier Type: -

Identifier Source: org_study_id

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