Armenian NAtionwide REGistry of Systemic Autoimmune and Autoinflammatory Diseases
NCT ID: NCT05904301
Last Updated: 2025-04-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
800 participants
OBSERVATIONAL
2023-06-21
2028-06-30
Brief Summary
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Detailed Description
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They represent a group of diseases characterized by excessive autoimmune or inflammatory reaction leading to various organ damage and drop in patient's quality of life, usually underlined by particular genetic factors and environmental triggers.
The progress of these diseases is often evaluated in the form of activity scores.
A number of scores are available to predict the evolution of autoimmune autoinflammatory diseases.
For a long time, these pathologies have remained slightly explored because of their complex physiopathology and the absence of specific therapies.
In the last few years, significant progress has been made in terms of both pathophysiology and treatment.
Treatment with biological targeted therapies transformed the prognosis and survival of the patients, improved their quality of life and underlined the necessity of a global management of these patients.
In Armenia, the epidemiological elements of these pathologies are not known, nor are the circumstances of their discovery. The initial biological manifestations and the management of these patients are variable from one center to another, whether in terms of supportive or specific therapeutic elements.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Systemic autoimmune and autoinflammatory diseases
Usual medical management of patients, additional blood and stool samples for biobanking
For all systemic diseases the following data will be collected:
Clinical examination, Laboratory data, Current medications, Constitution of biobanking.
For each disease:
Pathology specific Activity score, Global subjective disease activity by patient and by physician.
Interventions
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Usual medical management of patients, additional blood and stool samples for biobanking
For all systemic diseases the following data will be collected:
Clinical examination, Laboratory data, Current medications, Constitution of biobanking.
For each disease:
Pathology specific Activity score, Global subjective disease activity by patient and by physician.
Eligibility Criteria
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Inclusion Criteria
Behcet disease, ANCA -positive vasculitis, Takayasu arteritis, Giant cell arteritis, Systemic sclerosis, Sjogren syndrome, Rheumatoid arthritis, Spondylarthritis (psoriatic, ankylosing, crohn's related), Angioedema hereditary and acquired, Pediatric dermatology, Autoinflammatory diseases (hereditary and acquired), Unexplained infertility, Immune thrombocytopenic purpura/ Autoimmune hemolytic anemia (ITP, AHA), Primary anti-phospholipid syndrome (APS), Celiac disease.
2. Age: major and minor
3. Patients who have been informed and provided with written informed consent to participate Or consent from legal representative
Exclusion Criteria
2. Non-consent from legal representative
3. Breastfeeding or pregnant patients
ALL
No
Sponsors
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Santé Arménie French-Armenian Research Center
OTHER
Responsible Party
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Principal Investigators
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Merry Mazmanian, Dr.
Role: STUDY_DIRECTOR
Santé Arménie French - Armenian Academic Research Organization FAARO
Locations
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Hematology Center after Prof.R.H. Yeolyan
Yerevan, , Armenia
Nairi Medical Center, Rheumatology Department
Yerevan, , Armenia
Heratsi Hospital Complex n°1, Rheumatology Department
Yerevan, , Armenia
Heratsi Hospital Complex №1, Allergology Department
Yerevan, , Armenia
Mikaelyan Institute of Surgery, Rheumatology Department
Yerevan, , Armenia
Erebouni Medical Center, Rheumatology Department
Yerevan, , Armenia
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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SA-2021001
Identifier Type: -
Identifier Source: org_study_id
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