Detection and Characteristic of Whipple Diseases in the Great Britany

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

267 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-11-15

Study Completion Date

2018-02-09

Brief Summary

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Whipple's disease is a chronic systemic infection caused by ubiquitous bacterium Tropheryma wipplei on a genetic predisposition which should be considered in patients with recurrent episodes of seronegative arthritis, erosive or not, or inflammatory low back pain, chronic diarrhea, persistent fever, unexplained neurological signs, uveitis, endocarditis, and epithelioid granuloma.

Laboratory tests may show malabsorption, erythrocyte sedimentation rate and C-reactive protein elevation, anemia, thrombocytosis, eosinophilia and lymphopenia.

None of theses findings is specific and most patients have arthritis or low back pain mimicking rheumatoid arthritis and spondyloarthritis.

As the disease is rare, chance for positive polymerase chain reaction testing for Tropheryma whipplei is low in this context.

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Detailed Description

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Conditions

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Whipple Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Classic Whipple's disease (CWD)

Classic Whipple's disease (CWD), defined as

* duodenal biopsy positive by PAS/immunohistochemistry
* or blood positive by PCR

No interventions assigned to this group

Focal Whipple's disease (FWD)

Focal Whipple's disease (FWD), defined as

* joint fluid positive by PCR
* but duodenal biopsy negative by PAS/immunohistochemistry

No interventions assigned to this group

Chronic T. whipplei-associated arthritis (CTWA)

Chronic T. whipplei-associated arthritis (CTWA) defined as chronic arthritis and

* duodenal biopsy, stool, or saliva positive by PCR
* duodenal biopsy negative by PAS/immunohistochemistry
* joint fluid negative by PCR

No interventions assigned to this group