Assessing the Precision of Convolutional Neural Networks for Dental Age Estimation From Panoramic Radiographs

NCT ID: NCT05901857

Last Updated: 2023-06-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

22 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-06-30

Study Completion Date

2025-12-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this study is to assess the accuracy of a convolutional neural network in dental age estimation from digital panoramic radiographs. The reference standard will be the chronological age of the patient.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Willems method is a dental age estimation technique modified from Demirjian method by creating new tables from which a maturity score is directly expressed in years.

Panoramic radiographs of all participants will be taken with their informed consent, then they will be numbered and coded. Chronological age for each participant will be calculated by subtracting date of birth from date of radiograph and the real age will be blinded from the researcher (The chronological age is the ground truth). All panoramic radiographs will be examined twice by the main author to determine the dental age according to Willems method.

The seven mandibular left teeth excluding the third molar will be scored as '0' for absence of calcification, and 'A' to 'H', depending on the stage of calcification. Each letter corresponds to a score which is the dental age fraction using tables for boys and girls. Summing the scores for the seven left mandibular teeth directly will result in the estimated dental age. The dental radiologist estimation accurancy will be compared to the ground truth (first index test).

The second index test which will also be compared to the ground truth is the CNN model. To prepare the dataset for the CNN model, a rigorous preprocessing procedure will be followed. This will involve resizing the images to the desired dimensions, segmenting the teeth parts to be included in the image, and applying data augmentation techniques to enhance the quality and quantity of the dataset. The dataset will then be split into training and testing sets using a 20:80 ratio, which will be carefully selected based on the expected number of samples. Also the accuracy of the model will be assessed compared to the ground truth (the chronological ages).

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Age Problem

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

convolutional neural network

A deep learning model for dental age classification from panoramic images

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Presence of all mandibular left permanent teeth (except third molars)
* Clearly visible root development
* No systemic disease
* No history of root canal therapy or extraction
* No related diseases affecting mandibular development such as cysts or tumors.

Exclusion Criteria

* Patients with premature birth
* Facial asymmetry
* Congenital anomalies
* History of trauma or surgery in dentofacial region
Minimum Eligible Age

6 Years

Maximum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Cairo University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Rawan Abdel Wahhab Bahaa Eldin Elkassas

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Mohab Eid

Role: STUDY_CHAIR

Nile University

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Rawan Elkassas

Cairo, , Egypt

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Egypt

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Rawan Elkassas

Role: CONTACT

+201011385738

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

rawan elkassas

Role: primary

References

Explore related publications, articles, or registry entries linked to this study.

Banar N, Bertels J, Laurent F, Boedi RM, De Tobel J, Thevissen P, Vandermeulen D. Towards fully automated third molar development staging in panoramic radiographs. Int J Legal Med. 2020 Sep;134(5):1831-1841. doi: 10.1007/s00414-020-02283-3. Epub 2020 Apr 1.

Reference Type BACKGROUND
PMID: 32239317 (View on PubMed)

Ekert T, Krois J, Meinhold L, Elhennawy K, Emara R, Golla T, Schwendicke F. Deep Learning for the Radiographic Detection of Apical Lesions. J Endod. 2019 Jul;45(7):917-922.e5. doi: 10.1016/j.joen.2019.03.016. Epub 2019 Jun 1.

Reference Type BACKGROUND
PMID: 31160078 (View on PubMed)

El-Desouky SS, Kabbash IA. Age estimation of children based on open apex measurement in the developing permanent dentition: an Egyptian formula. Clin Oral Investig. 2023 Apr;27(4):1529-1539. doi: 10.1007/s00784-022-04773-7. Epub 2022 Nov 17.

Reference Type BACKGROUND
PMID: 36394611 (View on PubMed)

Galibourg A, Cussat-Blanc S, Dumoncel J, Telmon N, Monsarrat P, Maret D. Comparison of different machine learning approaches to predict dental age using Demirjian's staging approach. Int J Legal Med. 2021 Mar;135(2):665-675. doi: 10.1007/s00414-020-02489-5. Epub 2021 Jan 7.

Reference Type BACKGROUND
PMID: 33410925 (View on PubMed)

Guo YC, Han M, Chi Y, Long H, Zhang D, Yang J, Yang Y, Chen T, Du S. Accurate age classification using manual method and deep convolutional neural network based on orthopantomogram images. Int J Legal Med. 2021 Jul;135(4):1589-1597. doi: 10.1007/s00414-021-02542-x. Epub 2021 Mar 4.

Reference Type BACKGROUND
PMID: 33661340 (View on PubMed)

Kim S, Lee YH, Noh YK, Park FC, Auh QS. Age-group determination of living individuals using first molar images based on artificial intelligence. Sci Rep. 2021 Jan 13;11(1):1073. doi: 10.1038/s41598-020-80182-8.

Reference Type BACKGROUND
PMID: 33441753 (View on PubMed)

Sehrawat JS, Singh M. Willems method of dental age estimation in children: A systematic review and meta-analysis. J Forensic Leg Med. 2017 Nov;52:122-129. doi: 10.1016/j.jflm.2017.08.017. Epub 2017 Aug 25.

Reference Type BACKGROUND
PMID: 28918371 (View on PubMed)

Shen S, Liu Z, Wang J, Fan L, Ji F, Tao J. Machine learning assisted Cameriere method for dental age estimation. BMC Oral Health. 2021 Dec 15;21(1):641. doi: 10.1186/s12903-021-01996-0.

Reference Type BACKGROUND
PMID: 34911516 (View on PubMed)

Vila-Blanco N, Carreira MJ, Varas-Quintana P, Balsa-Castro C, Tomas I. Deep Neural Networks for Chronological Age Estimation From OPG Images. IEEE Trans Med Imaging. 2020 Jul;39(7):2374-2384. doi: 10.1109/TMI.2020.2968765. Epub 2020 Jan 31.

Reference Type BACKGROUND
PMID: 32012002 (View on PubMed)

Ye X, Jiang F, Sheng X, Huang H, Shen X. Dental age assessment in 7-14-year-old Chinese children: comparison of Demirjian and Willems methods. Forensic Sci Int. 2014 Nov;244:36-41. doi: 10.1016/j.forsciint.2014.07.027. Epub 2014 Aug 19.

Reference Type BACKGROUND
PMID: 25195126 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

ORAD 3-3-1 (2)

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.