Suture-mediated Closure System Following Endovascular Peripheral Arterial Procedures

NCT ID: NCT05899478

Last Updated: 2025-06-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

135 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-06-01

Study Completion Date

2024-04-01

Brief Summary

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The purpose of this study is to evaluate the effectiveness and safety of the suture-mediated closure system produced by Suzhou Hengrui Hongyuan Medical Technology Co., Ltd. following endovascular peripheral arterial procedures.

Detailed Description

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Prospective, multi-center, randomized Comparative study using the Suture-mediated Closure System produced by Suzhou Hengrui Hongyuan Medical Technology Co., Ltd.as an investigational device and the Perclose® ProGlide Suture-Mediated Closure System as a comparator.

After going through the confirmation of inclusion/exclusion criteria with signed subjects, they will have a procedure either of the two devices. The subjects should follow designated physician's instructions accurately during the clinical trial period. There are about 4 times evaluations Including screening.

Conditions

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Percutaneous Intervention Via Femoral Artery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Tyknot® Suture-Mediated Closure System

Arterial closure device used is Tyknot® Suture-Mediated Closure System

Group Type EXPERIMENTAL

Tyknot® Suture-Mediated Closure System

Intervention Type DEVICE

Arterial closure to ensure hemostasis at femoral artery puncture points

Perclose® ProGlide Suture-Mediated Closure System

Arterial closure device used is Perclose® ProGlide Suture-Mediated Closure System

Group Type ACTIVE_COMPARATOR

Perclose® ProGlide Suture-Mediated Closure System

Intervention Type DEVICE

Arterial closure to ensure hemostasis at femoral artery puncture points

Interventions

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Tyknot® Suture-Mediated Closure System

Arterial closure to ensure hemostasis at femoral artery puncture points

Intervention Type DEVICE

Perclose® ProGlide Suture-Mediated Closure System

Arterial closure to ensure hemostasis at femoral artery puncture points

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Aged 18-80
2. Patients who can use 5Fr to 21Fr sheath for common femoral artery puncture for interventional catheterization or therapy
3. Informed consent signed by the patient or legal representative

Exclusion Criteria

1. Pregnancy or lactation period;
2. Diameter of femoral artery site for puncture\< 5mm;
3. Have participated in another clinical study during the same period;
4. Known allergy to any device component, and/or contraindications of contrast agents and anticoagulants;
5. Vascular injury at the site of the approach;
6. Groin infection;
7. Morbid obesity (BMI≥40kg / ㎡);
8. Ultrasonographic assessment of the entire common femoral artery wall showed that the common femoral artery stenosis was ≥ 50%;
9. There are femoral aneurysms, arteriovenous fistulas or pseudoaneurysms in the common femoral artery;
10. Clamp vessel closures were used at the previous ipsilateral artery approach;
11. Hematoma at ipsilateral artery approach;
12. Other conditions deemed unsuitable for participation in this clinical trial by the investigator.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Suzhou Hengruihongyuan Medical Technology Co. LTD

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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The First Affiliated Hospital of USTC

Hefei, Anhui, China

Site Status

Zhongshan Hospital

Shanghai, Shanghai Municipality, China

Site Status

Affiliated Hangzhou First People's Hospital ,Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

Site Status

The Second Affiliated Hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

Site Status

The Fourth Affiliated Hospital ,Zhejiang University School of Medicine

Yiwu, Zhejiang, China

Site Status

Countries

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China

Other Identifiers

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SPD01

Identifier Type: -

Identifier Source: org_study_id

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