A Multicenter Prospective Cohort Study Study of CLAG Regimen in Acute Myeloid Leukemia Patients With First-induction Failure

NCT ID: NCT05875649

Last Updated: 2023-07-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

137 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-07-02

Study Completion Date

2027-12-20

Brief Summary

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Most of patients with acute myeloid leukemia achieved complete remission (CR) after primary induction chemotherapy, there were 20-30% patients without CR after first-induction. It was uncertain how to treat these patients. It was investigated in our study that these patients were re-induced with CLAG Regimen. The CR ratio, overall survival (OS) and relapsed-free survival (RFS) was statistically analysed in these patients.

Detailed Description

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Conditions

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AML

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Group

Acute myeloid leukemia patients with first-induction failure

CLAG

Intervention Type COMBINATION_PRODUCT

Acute myeloid leukemia patients are re-induced by CLAG Regimen after first-induction failure

Interventions

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CLAG

Acute myeloid leukemia patients are re-induced by CLAG Regimen after first-induction failure

Intervention Type COMBINATION_PRODUCT

Eligibility Criteria

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Inclusion Criteria

* Acute myeloid leukemia patients with first-induction failure

Exclusion Criteria

* Acute myeloid leukemia patients with serious infection and organ dysfunction.
Minimum Eligible Age

14 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nanfang Hospital, Southern Medical University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Xuejie Jiang, Doctor

Role: STUDY_CHAIR

Nanfang Hospital, Southern Medical University

Locations

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Nanfang Hospital of Southern Medical University

Guanzhou, Guangdong, China

Site Status

Nanfang Hospital of Southern Medical University

Guanzhou, Guangdong, China

Site Status

Countries

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China

Central Contacts

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Xuejie Jiang, Doctor

Role: CONTACT

+86 18688869522

Facility Contacts

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Xuejie Jiang, doctor

Role: primary

+8618688869522

Other Identifiers

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NEFC-2023-162

Identifier Type: -

Identifier Source: org_study_id

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