Postoperative Gastrointestinal Dysfunction After High Risk Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

66 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-01-23

Study Completion Date

2023-12-31

Brief Summary

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This study aims to find out the role of plasma I-FABP level, SOFA score, fluid balance, and vasopressor dose in predicting gastrointestinal dysfunction in high-risk postoperative patients treated in ICU

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Detailed Description

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This is a prospective cohort study to find out the role of plasma I-FABP level, SOFA score, fluid balance, and vasopressor dose in predicting gastrointestinal dysfunction in high-risk postoperative patients treated in ICU. The characteristics of patients who meet the eligibility criteria were obtained. Blood sampling during admission is done for I-FABP level measurement and will be repeated after 24 hours. Blood sample which is not directly processed will be stored in refrigerator under 6-8C temperature. Evaluation of Acute Gastrointestinal Injury signs and symptoms is done. The re-evaluation is performed every day. If patients experiencing AGI signs and symptoms, monitoring and treatment based on condition are done. Routine follow-up is continued during hospitalisation in ICU. After all sample are collected, I-FABP level is assessed quantitatively using ELISA.

Conditions

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Gastrointestinal Dysfunction Surgery Postoperative Complications

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Experience gastrointestinal dysfunction

Gastrointestinal dysfunction is defined as acute gastrointestinal injury (AGI) score \>= 2 based on ESICM criteria, monitored within 72 hours according to early postoperative gastrointestinal dysfunction.

Experience gastrointestinal dysfunction = AGI score \>=2

No interventions assigned to this group

Did not experience gastrointestinal dysfunction

Did not experience gastrointestinal dysfunction = AGI score \<2

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* High-risk postoperative patients
* Patients treated in Intensive Care Unit of Emergency Department or Surgery Unit in Cipto Mangunkusumo General Hospital
* Age \>18 years old
* Patients or family give written consent to follow the study

Exclusion Criteria

* Patients with late trimester-pregnancy when admitted to ICU
* Patients undergo cardiac surgery
* Patients with gastrointestinal disorders requiring routine therapy
* Patients undergo surgery involving bowels
* Patients undergo surgical treatment for burn
* Patients treated in ICU \>24 hours before surgery

Drop-out Criteria

* Unable to obtain blood sampling for I-FABP level examination in ICU
* Unable to perform Acute Gastrointestinal Injury examination in ICU
* Patients died within \<24 hours treatment in ICU
* Patients or family decide to quit from the study

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No