Influence of Nutrition on Lung Microbiota in Traumatic Brain Injury
NCT ID: NCT05854264
Last Updated: 2023-05-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
30 participants
INTERVENTIONAL
2021-02-01
2023-05-01
Brief Summary
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For these reasons, the aims of our study are the evaluation of the impact of immunonutrition on the lung microbiota and the relationship between lung microbiota and infection in TBJ patients in ICU.
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Detailed Description
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Lower lavage (Bronco Alveolar Lavage: BAL) samples will be collected at admission in ICU and at day 7 for the microbiota analysis. Clinical follow-up at day 28 will be obtained
Conditions
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Study Design
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RANDOMIZED
PARALLEL
DIAGNOSTIC
SINGLE
Study Groups
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microbiota and specialized nutrition
microbiota analysis in lower lavage (Bronco Alveolar Lavage: BAL) samples in patietns treated with specialized nutrition
specialized nutrition
specialized enteral nutrition. The calories (25 kcal/kg/die) and protein (1.2 g/kg/die) target will be progressively reached in the first week of ICU stay.
microbiota and standard nutrition
microbiota analysis in lower lavage (Bronco Alveolar Lavage: BAL) samples in patients treated with standard nutrition
standard enteral nutrition
standard enteral nutrition. The calories (25 kcal/kg/die) and protein (1.2 g/kg/die) target will be progressively reached in the first week of ICU stay.
Interventions
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standard enteral nutrition
standard enteral nutrition. The calories (25 kcal/kg/die) and protein (1.2 g/kg/die) target will be progressively reached in the first week of ICU stay.
specialized nutrition
specialized enteral nutrition. The calories (25 kcal/kg/die) and protein (1.2 g/kg/die) target will be progressively reached in the first week of ICU stay.
Eligibility Criteria
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Inclusion Criteria
* paziente with traumatic brain injury
Exclusion Criteria
* patients with gastric content inhalation
* patients with chronic inflammatory bowel diseases
* patients underwent major abdominal surgery and/or organs/tissues transplant
* patients on corticosteroid and/or immunosuppressive therapy
18 Years
80 Years
ALL
No
Sponsors
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University of Foggia
OTHER
Responsible Party
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Cotoia Antonella
Principal Investigator
Locations
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Ospedali Riuniti
Foggia, Apulia, Italy
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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46/CE/2022
Identifier Type: -
Identifier Source: org_study_id
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