Study if the Presence of Functional FcERI/RII on the Surface of Human Blood Platelet

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-06-01

Study Completion Date

2025-04-01

Brief Summary

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Anaphylactic shock is the most severe expression of immediate hypersensitivity reactions. The mechanisms leading to these reactions are still poorly understood and may involve platelets, especially in the most severe forms.

The IgE ( ImmunoglobulineE)-mediated mechanism, involving the FcERI(the high-affinity receptor for the Fc region of immunoglobulin E (IgE) receptor present on the surface of mast cells and basophilic cells, is the most common mechanism. The receptors FcERI and FcERII are also described as being present on the surface of blood platelets, which would imply their activation along with the other cells involved. However, studies showing the presence of the FcERI/RII receptors on blood platelets suffer from many biases.

The main objective of the research is to study whether the FcERI/RII receptors are present and functional on the surface of blood platelets from allergic patients.

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Detailed Description

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Conditions

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Allergy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Interventions

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Flow cytometry

Analysis of blood samples from a health sample's allergic patients and analysis with flow cytometry

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age \> 18 years-old
* With a protein/drug allergy (hymenoptera, arachide, amoxicillin)
* Confirmed by skin tests and/or challenge test
* With specific IgEs