Home-based Training and Supplementation in DM1 Patients

NCT ID: NCT05848830

Last Updated: 2023-10-19

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE3
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-01-01
• Study Completion Date: 2025-01-01

Brief Summary

Myotonic dystrophy type 1 (DM1) is a rare genetic disease that affects about 1 in 2100 people. Patients diagnosed with DM1 present with many symptoms, however, their muscles are mainly affected. DM1 patients experience a gradual loss of muscle, followed by an increase in body fat percentage, which makes them weaker, resulting in difficulties to perform activities of daily living, such as climbing stairs, and understandably, this affects their quality of life. DM1 currently does not have a cure. Therefore, it is very important to find ways in which we can help DM1 patients to improve their symptoms, and hopefully, improve their quality of life, and possibly improve disease prognosis. Exercise is known to improve muscle quality and function. In addition, we hypothesize that a multi-ingredient supplement (MIS) for muscle health and antioxidants for fat loss, might show improved benefits on top of exercise. Therefore, we will investigate the effects of 16-week home-based concurrent training, with MIS or placebo, on body composition, and functional measures. Lastly, we will investigate muscle adaptations in DM1 and following study intervention

Detailed Description

The present study will target patients (male and female) that have been clinically diagnosed with myotonic dystrophy type 1 with 100-1000 CTG repeats, between the ages of 19 - 60. In addition, a healthy population will serve as baseline controls, and they will be matched for age and sex, to the DM1 patients.

A total of 40 DM1 patients and 20 healthy controls will be recruited. DM1 patients will be randomized to 20 in the active group and 20 in the placebo. Both males and females will be recruited, targeting 20 males and 20 females. Corresponding 10 healthy males and 10 healthy females will be matched for sex and age, and only participate in baseline visits, measures, and sample collection.

Home-based concurrent training (HBCT) represents an exercise intervention with minimal barriers to entry. Our study will assess the effectiveness of this intervention, in combination with a multi-ingredient supplement (MIS) containing protein, creatine, antioxidants, and other dietary supplements in patients with DM1, in improving functional, clinical, and strength measures, as well as the quality of life, as assessed by scores in questionnaires. In addition, we will investigate adaptations to skeletal muscle following HBCT and MIS.

A randomized clinical trial of DM1 patients. Our study will include exercise as the over-arching intervention, with two groups nested within, DM1 patients randomized to MIS and placebo, both of which will undergo 16 weeks of home-based exercise training. Measurements and samples will be collected before and after the study intervention. A third group will include age and sex-matched healthy controls. This group will not undergo training + supplement intervention and will be used for baseline comparisons between healthy participants and DM1 patients.

Study procedures will include blood draws and muscle biopsies in each visit. In addition, participants will be asked to undergo a cardiorespiratory fitness test (VO2MAX test), a battery of functional tests (6-minute walk test, 5x sit-to-stand, one leg standing, 4-stair climb), strength testing (grip strength and knee extension tests) and lastly, clinical procedures, including ECGs and spirometry. Measurements and sample collection will be done before and after the study intervention.

Conditions

Myotonic Dystrophy 1

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: FACTORIAL
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: TRIPLE

Study Groups

DM1 + HBEXT + MIS

Participants will be asked to undergo 16 weeks of home-based training and asked to take one dose of a multi-ingredient supplement per day.

Group Type: ACTIVE_COMPARATOR

Mult-ingredient supplement

Intervention Type: DIETARY_SUPPLEMENT

A mult-ingredient supplement containing Protein, both whey and casein, Creatine, Vitamin D, and Calcium. As well as antioxidants and other dietary supplements including Vitamin E, CoQ10, Alpha Lipoic Acid, L-Arginine, Beet Root Extract, Green Coffee Bean Extract, Green Tea Extract, Black Tea Extract, Curcumin, and Forskolin

Concurrent exercise training

Intervention Type: BEHAVIORAL

All participants will undergo 16-weeks of exercise training, containing 3 days/week of resistance training and 2days/ week of aerobic training.

DM1 + HBEXT + PLA

Participants will be asked to undergo 16 weeks of home-based training and asked to take one dose of a multi-ingredient supplement placebo per day.

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DIETARY_SUPPLEMENT

The placebo sachet will contain micro-crystalline cellulose (inactive compound) and will be identical in look and taste to the active supplement.

Concurrent exercise training

Intervention Type: BEHAVIORAL

All participants will undergo 16-weeks of exercise training, containing 3 days/week of resistance training and 2days/ week of aerobic training.

CONTROL

Healthy control subjects who will not undergo study intervention and will be used for baseline measurements and outcomes.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Mult-ingredient supplement

A mult-ingredient supplement containing Protein, both whey and casein, Creatine, Vitamin D, and Calcium. As well as antioxidants and other dietary supplements including Vitamin E, CoQ10, Alpha Lipoic Acid, L-Arginine, Beet Root Extract, Green Coffee Bean Extract, Green Tea Extract, Black Tea Extract, Curcumin, and Forskolin

Intervention Type: DIETARY_SUPPLEMENT

Placebo

The placebo sachet will contain micro-crystalline cellulose (inactive compound) and will be identical in look and taste to the active supplement.

Intervention Type: DIETARY_SUPPLEMENT

Concurrent exercise training

All participants will undergo 16-weeks of exercise training, containing 3 days/week of resistance training and 2days/ week of aerobic training.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Healthy men and women
• Normal BMI (BMI 18.5 - 24.9 kg/m2)

• Male or female clinically diagnosed with DM1 (age 19 - 60 y).
• CTG repeats 100-1000.
• Normal weight (BMI 18.5 - 24.9 kg/m2) or overweight (BMI 25 - 29.9 kg/m2).
• Physically inactive (< 1 hour of formal exercise/week).
• 6-minute walk test score between 250 - 500 meters
• ECG with PR interval < 225 ms and QRS duration < 125 ms.

Exclusion Criteria

• Smoking
• Obese (BMI > 30.0 kg/m2)
• Physically active (> 1-2 hour of formal exercise/week)
• 6-minute walk test score <250 meters, chronic (> 2 weeks)
• Use of narcotic analgesic or anti-inflammatory drugs
• Type 1 or 2 diabetes (more than one anti-diabetic drug)
• Cardiovascular disease (recent myocardial infarction (< 6 months)
• Uncontrolled hypertension requiring more than 2 medications.
• Congestive heart failure requiring more than one medication for control.
• Cardiac conduction block (as above)
• Renal disease (creatinine > 140)
• Known liver disease
• Cognitive impairments limiting ability to provide informed consent
• Previous stroke with residual hemiparesis
• Active musculoskeletal injuries and/or severe osteoarthritis
• Significant weight loss in the 3-month period prior to the study
• Severe peripheral neuropathy
• Severe osteoporosis
• Use of medications known to affect protein metabolism (i.e. corticosteroids)
• Chronic obstructive or restrictive pulmonary disease (FVC < 70% of age predicted mean value)
• Asthma requiring more than two medications.

• Minimum Eligible Age: 19 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

McMaster University

OTHER

Sponsor Role: lead

Responsible Party

Mark Tarnopolsky

Principal Investigator, Professor, Director of Neuromuscular and Neurometabolic Clinic

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

McMaster University Medical Center

Hamilton, Ontario, Canada

Countries

Canada

Central Contacts

Mark A Tarnopolsky, MD, PhD

Role: CONTACT

tarnopol@mcmaster.ca

905-525-9140 ext. 75226

Joshua P Nederveen, PhD

Role: CONTACT

nedervj@mcmaster.ca

905-902-0583

Other Identifiers

15550

Identifier Type: -

Identifier Source: org_study_id