A Study of the Intervention Effect of a Hybrid Exercise Program on Frail Elderly

NCT ID: NCT05832853

Last Updated: 2023-04-27

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 181 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-05-20
• Study Completion Date: 2019-01-30

Brief Summary

The declining physical condition of frail elderly is becoming an ugent problem. Although the exercise intensity of Wu Qin Xi appears to be low, it is highly effective in the older individuals. Inspired by the characteristics and functions of Wu Qin Xi, we designed a brand new exercise intervention training program among frail older people, which incorporates Wu Qin Xi, strength exercises and endurance exercises to improve physical fitness, and even reverse the condition of frailty. Furthermore, to improve utility in clinical practice, we innovatively employed machine learning simulations to infer the condition of older adults and predict their level of frailty after the intervention.

Conditions

Frail Elderly Syndrome

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: DOUBLE

Study Groups

Wu Qin Xi exercise

The training schedule for Wu Qin Xi consisted of two phases: the first phase lasted for eight weeks, while the second phase lasted for 16 weeks. In the first phase, Wu Qin Xi group was given twice repetitions of the intervention. The second phase consisted of three repetitions of the Wu Qin Xi group.

Group Type: EXPERIMENTAL

Wu Qin Xi exercise

Intervention Type: BEHAVIORAL

The training schedule for Wu Qin Xi consisted of two phases: the first phase lasted for eight weeks, while the second phase lasted for 16 weeks. In the first phase, Wu Qin Xi group was given twice repetitions of the intervention. The second phase consisted of three repetitions of the Wu Qin Xi group. Participants warmed up for 20 min prior to the intervention and cooled down for 10 min at the end.

Wu Qin Xi, resistance training and endurance training

The trial was divided into three cycles, each lasting eight weeks. Participants performed a hybrid program of Wu Qin Xi exercise, resistance training and endurance training of varying duration and intensity in each cycle. Each session lasted one hour, three times a week for 24 weeks.

Group Type: EXPERIMENTAL

Wu Qin Xi, resistance training and endurance training

Intervention Type: BEHAVIORAL

During the first 8 weeks, the training consists of learning and consolidating the movements of the Wu Qin Xi. In the second 16 weeks, participants perform a full set of movement exercises. Each resistance training session contained two lower-body exercises (seated calf raises and hip abduction) and three upper-body exercises (lateral pull downs, biceps curls, and triceps push downs) and two sets for each exercise. Endurance training is performed by continuous walking on an undisturbed indoor track for 15 min. Participants warmed up for 20 min prior to the intervention and cooled down for 10 min at the end.

Resistance training and endurance training

The trial was divided into three cycles, each lasting eight weeks. Participants performed a hybrid program of resistance training and endurance training of varying duration and intensity in each cycle. Each session lasted one hour, three times a week for 24 weeks.

Group Type: EXPERIMENTAL

Resistance training and endurance training

Intervention Type: BEHAVIORAL

Each resistance training session contained two lower-body exercises (seated calf raises and hip abduction) and three upper-body exercises (lateral pull downs, biceps curls, and triceps push downs) and three sets for each exercise. Endurance training is performed by continuous walking on an undisturbed indoor track for 30 min. Participants warmed up for 20 min prior to the intervention and cooled down for 10 min at the end.

Interventions

Wu Qin Xi exercise

The training schedule for Wu Qin Xi consisted of two phases: the first phase lasted for eight weeks, while the second phase lasted for 16 weeks. In the first phase, Wu Qin Xi group was given twice repetitions of the intervention. The second phase consisted of three repetitions of the Wu Qin Xi group. Participants warmed up for 20 min prior to the intervention and cooled down for 10 min at the end.

Intervention Type: BEHAVIORAL

Wu Qin Xi, resistance training and endurance training

During the first 8 weeks, the training consists of learning and consolidating the movements of the Wu Qin Xi. In the second 16 weeks, participants perform a full set of movement exercises. Each resistance training session contained two lower-body exercises (seated calf raises and hip abduction) and three upper-body exercises (lateral pull downs, biceps curls, and triceps push downs) and two sets for each exercise. Endurance training is performed by continuous walking on an undisturbed indoor track for 15 min. Participants warmed up for 20 min prior to the intervention and cooled down for 10 min at the end.

Intervention Type: BEHAVIORAL

Resistance training and endurance training

Each resistance training session contained two lower-body exercises (seated calf raises and hip abduction) and three upper-body exercises (lateral pull downs, biceps curls, and triceps push downs) and three sets for each exercise. Endurance training is performed by continuous walking on an undisturbed indoor track for 30 min. Participants warmed up for 20 min prior to the intervention and cooled down for 10 min at the end.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

1. a Fried frailty phenotype score of 3-5 points;

2. could walk for at least 6 min without support;

3. had not been able to walk in the past year other training.

Exclusion Criteria

1. people who have a past mental illness or serious psychological issues which make it difficult to obey orders;

2. people who have had neurological disorders within the last six months;

3. people who must regularly participate in other training programs during the study period;

4. people who struggle to walk normally due to significant muscle and skeletal injuries and continuous joint discomfort.

• Minimum Eligible Age: 60 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Guang Yang, Prof. Dr.

OTHER

Sponsor Role: lead

Responsible Party

Guang Yang, Prof. Dr.

Prof.Dr.

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

Chinese Center of Exercise Epidemiology

Changchun, Jilin, China

Countries

China

References

Wei M, He S, Meng D, Yang G, Wang Z. Hybrid Exercise Program Enhances Physical Fitness and Reverses Frailty in Older Adults: Insights and Predictions from Machine Learning. J Nutr Health Aging. 2023;27(10):894-902. doi: 10.1007/s12603-023-1991-0.

Reference Type: DERIVED

PMID: 37960913 (View on PubMed)

Other Identifiers

CCEE2018

Identifier Type: -

Identifier Source: org_study_id