Multicenter Retrospective Study of Isoflurane in Refractory and Super-Refractory Status Epilepticus

NCT ID: NCT05830864

Last Updated: 2025-09-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

66 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-06-30

Study Completion Date

2025-09-22

Brief Summary

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Isoflurane might be used as anticonvulsive therapy in refractory status epilepticus. The aim of the study is to assess the efficiency of Isoflurane in this indication.

Detailed Description

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Investigators will collect in 4 ICUs the data from consecutive patients hospitalized between january 2016 and january 2023. Included patient were those treated by Isoflurane for refractory status epilepticus.

Conditions

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Refractory Status Epilepticus

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Main cohort

Adult patients with refractory status epilepticus treated by Isoflurane as third anticonvulsive therapy

Isoflurane

Intervention Type DRUG

no other intervention

Interventions

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Isoflurane

no other intervention

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Age \> 18 years, hospitalized in ICU between 2016-01-01 and 2023-01-01, suffering refractory status epilepticus treated by inhaled Isoflurane as third anticonvulsive therapy

Exclusion Criteria

* post-anoxic refractory status epilepticus after cardiac arrest, withdrawal of consent for medical data use
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hopital of Melun

OTHER

Sponsor Role lead

Responsible Party

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Sebastien Jochmans, MD

Director of Clinical Research Unit

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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SEBASTIEN JOCHMANS, MD

Role: STUDY_DIRECTOR

GHSIF MELUN

Locations

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Ch Bethune Beuvry

Beuvry, , France

Site Status

CHU Brest

Brest, , France

Site Status

GH Sud Ile de France, Hôpital de Melun-Sénart

Melun, , France

Site Status

CH Toulon - Sainte Musse

Toulon, , France

Site Status

Countries

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France

References

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Meiser A, Volk T, Wallenborn J, Guenther U, Becher T, Bracht H, Schwarzkopf K, Knafelj R, Faltlhauser A, Thal SC, Soukup J, Kellner P, Druner M, Vogelsang H, Bellgardt M, Sackey P; Sedaconda study group. Inhaled isoflurane via the anaesthetic conserving device versus propofol for sedation of invasively ventilated patients in intensive care units in Germany and Slovenia: an open-label, phase 3, randomised controlled, non-inferiority trial. Lancet Respir Med. 2021 Nov;9(11):1231-1240. doi: 10.1016/S2213-2600(21)00323-4. Epub 2021 Aug 26.

Reference Type BACKGROUND
PMID: 34454654 (View on PubMed)

Stetefeld HR, Schaal A, Scheibe F, Nichtweiss J, Lehmann F, Muller M, Gerner ST, Huttner HB, Luger S, Fuhrer H, Bosel J, Schonenberger S, Dimitriadis K, Neumann B, Fuchs K, Fink GR, Malter MP; IGNITE Study Group, with support from the German Neurocritical Care Society (DGNI). Isoflurane in (Super-) Refractory Status Epilepticus: A Multicenter Evaluation. Neurocrit Care. 2021 Dec;35(3):631-639. doi: 10.1007/s12028-021-01250-z. Epub 2021 Jul 20.

Reference Type BACKGROUND
PMID: 34286464 (View on PubMed)

Other Identifiers

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MIR-2023-01

Identifier Type: -

Identifier Source: org_study_id

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