Evaluation of Apexogenesis With Human Treated Dentin Matrix in Young Permanent Molars
NCT ID: NCT05830695
Last Updated: 2024-07-30
Study Results
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Basic Information
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COMPLETED
PHASE1/PHASE2
20 participants
INTERVENTIONAL
2022-01-18
2023-03-31
Brief Summary
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Detailed Description
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Group I (Study group): 20 molars were treated with human TDM. Group II: (Control group): 20 molars were treated with White MTA. The participating cases were evaluated clinically and radiographically after 6, 12 and 18 months. Tomographic evaluation was performed immediate postoperatively and at 18 months.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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human treated dentin matrix
study group
human treated dentin matrix
human treated dentin matrix is compared with mineral trioxide aggregate in apexogenesis
mineral tri oxide aggregate
control group
Mineral Trioxide Aggregate
mineral trioxide aggregate was used as control
Interventions
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human treated dentin matrix
human treated dentin matrix is compared with mineral trioxide aggregate in apexogenesis
Mineral Trioxide Aggregate
mineral trioxide aggregate was used as control
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. Positive response to pulp testing.
3. Normal radiographic appearance.
4. Healthy children without any systemic disease that interferes with pulp healing.
5. Patient and parent cooperation.
Exclusion Criteria
2. Presence of periapical lesion, external or internal root resorption.
3. Carious furcation involvement.
4. Dystrophic calcification of the pulp.
5. Non restorable tooth.
6 Years
8 Years
ALL
Yes
Sponsors
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nora mostafa mohammed abo shanady
OTHER
Responsible Party
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nora mostafa mohammed abo shanady
Assistant lecturer at pediatric dentistry oral health and preventive dentistry department
Locations
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Faculty of Dentistry, Tanta University
Tanta, El Gharbia, Egypt
Countries
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References
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Li R, Guo W, Yang B, Guo L, Sheng L, Chen G, Li Y, Zou Q, Xie D, An X, Chen Y, Tian W. Human treated dentin matrix as a natural scaffold for complete human dentin tissue regeneration. Biomaterials. 2011 Jul;32(20):4525-38. doi: 10.1016/j.biomaterials.2011.03.008. Epub 2011 Mar 31.
Tabatabaei FS, Tatari S, Samadi R, Torshabi M. Surface characterization and biological properties of regular dentin, demineralized dentin, and deproteinized dentin. J Mater Sci Mater Med. 2016 Nov;27(11):164. doi: 10.1007/s10856-016-5780-8. Epub 2016 Sep 21.
Widbiller M, Eidt A, Wolflick M, Lindner SR, Schweikl H, Hiller KA, Buchalla W, Galler KM. Interactive effects of LPS and dentine matrix proteins on human dental pulp stem cells. Int Endod J. 2018 Aug;51(8):877-888. doi: 10.1111/iej.12897. Epub 2018 Feb 17.
Chen J, Cui C, Qiao X, Yang B, Yu M, Guo W, Tian W. Treated dentin matrix paste as a novel pulp capping agent for dentin regeneration. J Tissue Eng Regen Med. 2017 Dec;11(12):3428-3436. doi: 10.1002/term.2256. Epub 2017 Feb 15.
Mehrvarzfar P, Abbott PV, Mashhadiabbas F, Vatanpour M, Tour Savadkouhi S. Clinical and histological responses of human dental pulp to MTA and combined MTA/treated dentin matrix in partial pulpotomy. Aust Endod J. 2018 Apr;44(1):46-53. doi: 10.1111/aej.12217. Epub 2017 Aug 18.
Other Identifiers
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12-3456
Identifier Type: -
Identifier Source: org_study_id
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