Time Restricted Eating With or Without a Fiber Supplement for Weight Management in Pediatric Cancer Survivors

NCT ID: NCT05826184

Last Updated: 2025-10-03

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 13 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-11-17
• Study Completion Date: 2025-07-01

Brief Summary

This study aims to address a critical gap in pediatric oncology survivorship care by exploring innovative solutions to addressing obesity and its comorbidities in pediatric cancer survivors. The majority (99%) of pediatric cancer survivors will develop severe chronic health conditions by age 50, with 96% developing at least one severe/disabling, life threating or fatal chronic health condition. Obesity, cardiovascular, and metabolic diseases are the most common treatment-related late effects among pediatric cancer survivors. Improving diet and reducing obesity has the potential to dramatically improve the quality of life and long-term health of pediatric cancer survivors. Utilization of a prebiotic fiber supplement along with TRE amy improve the gut microbiome, short-chain fatty acid synthesis, and hunger hormones to further improve weight loss with TRE and a greater decrease in cardiometabolic risk. The aims of this study are to test the safety, feasibility, and acceptability of 8-h TRE or 8-h TRE with a fiber supplement among young adult (YA) pediatric cancer survivors. The investigators further strive to examine the preliminary efficacy of TRE on body weight, body composition, glucose regulation, and cardiovascular risk markers. Data obtained will be used to inform a larger efficacy trial of TRE among adolescent and young adult pediatric cancer survivors. Given that a majority of pediatric cancer survivors will develop severe chronic health conditions by age 50, with 96% developing at least one severe/disabling, life threating or fatal chronic health condition exploring accessible nutritional strategies to improve long term health trajectory of 70,000+ AYA diagnosed with cancer each year in the United States. This study of TRE will provide important preliminary evidence of the benefits of this nutrition therapy for YA pediatric cancer survivors. The long-term goal of this line of inquiry is to improve both short and long-term outcomes for YA pediatric cancer survivors.

Conditions

Weight, Body

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Time restricted eating

Individuals will eat between 12-8pm ad libitum, fasting from 8-12pm.

Group Type: EXPERIMENTAL

Time restircted eating

Intervention Type: BEHAVIORAL

8 hour time restricted eating alone

TRE+ prebiotic supplement

Individuals will eat between 12-8pm ad libitum, fasting from 8-12pn with the addition of a prebiotic fiber supplement with the first eating bout of the day.

Group Type: EXPERIMENTAL

Time restricted eating + prebiotic

Intervention Type: BEHAVIORAL

8 hour TRE with a prebiotic supplement

Interventions

Time restircted eating

8 hour time restricted eating alone

Intervention Type: BEHAVIORAL

Time restricted eating + prebiotic

8 hour TRE with a prebiotic supplement

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Age 18-39 years old at time of consent
• Completed anti-tumor treatment for pediatric cancer
• BMI 25-39.99 kg/m2
• Able to provide (self or guardian) written informed consent and HIPAA authorization for release of personal health information, via an approved UIC Institutional Review Board (IRB) informed consent form and HIPAA authorization.
• As determined at the discretion of the enrolling physician or protocol designee, ability of the subject to understand and comply with study procedures for the entire length of the study.

Exclusion Criteria

Subjects meeting any of the criteria below may not participate in the study:

• Individuals <18 or >39 years of age
• Individuals on glucoregulatory medication
• Individuals with BMI ≥ 40kg/m2 and < 25kg/m2
• Individuals who are pregnant, trying to become pregnant or breast feeding. A negative serum or urine pregnancy test is required per institutional practice guidelines at screening as well as prior to all DXA scans.
• Shift workers who maintain a work schedule that crosses 12:00 am > 1 day per week
• Individuals with a history of eating disorders
• Active infection requiring systemic therapy
• Uncontrolled HIV/AIDS or active viral hepatitis
• Any mental or medical condition that prevents the patient from giving informed consent or participating in the trial.
• Other major comorbidity, as determined by study PI
• Illicit drug use (excluding self-reported marijuana) or excessive use of alcohol (i.e., > 2 drinks/day)
• Currently participating in Weight Watcher's or another weight loss program with a ≥ 3% weight loss in three months prior to recruitment
• History of: Myocardial infarction, Stroke, Congestive heart failure, Chronic hepatitis, Cirrhosis, Chronic pancreatitis
• History of solid organ transplantation
• Individual does not have access to the Internet
• Individuals who have taken antibiotics < 2 months prior to the initiation of the study
• Individuals who regularly use (≥ 3 times per week) prebiotics, probiotics, synbiotics, prebiotic supplements or laxatives within the past month

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 39 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Illinois at Chicago

OTHER

Sponsor Role: lead

Responsible Party

Kelsey Nicole Dipman Gabel

Clinial Assistant Professor and Postdoctoral Researcher

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Kelsey Gabel, PhD

Role: PRINCIPAL_INVESTIGATOR

UIC

Locations

University of Illinois at Chicago

Chicago, Illinois, United States

Countries

United States

Other Identifiers

STUDY2022-0745

Identifier Type: -

Identifier Source: org_study_id