Study of Serum Tumor Markers of HBV Associated HCC

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

164 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-05-01

Study Completion Date

2025-12-31

Brief Summary

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In this study, the investigators will detect the expression of four potential HBV-related HCC biomarkers: PGIR,FAM3C,LAMB1 and SDC4 in tumor tissues and peripheral blood, to explore the specific molecular markers for the early diagnosis of HBV-related HCC.

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Detailed Description

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Paired hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and adjacent liver tissues were selected, and the mRNA and protein expressions of the PGIR,FAM3C,LAMB1 and SDC4 biomarkers in tissues were detected by RT-PCR, western Blot and immunohistochemical analysis. At the same time, healthy subjects were selected as the control group, and mRNA and protein expression levels of the above molecules in blood were detected by RT-PCR and ELISA. At the same time, the correlation between the above biomarkers and the clinical data of patients, such as diagnosis, pathological grading, recurrence, metastasis and survival time was statistically analyzed.

Conditions

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HCC

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

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HBV-associated HCC group

The patient was finally diagnosed with HBV-related HCC by examination and imaging examination, and the clinicopathologic data were complete.

tumor tissue and blood tests

Intervention Type DIAGNOSTIC_TEST

In this study, we need to collect an extra tube of blood for routine testing and the tissue after completion of pathological examination.

negative control group

HBV positive but not HCC

tumor tissue and blood tests

Intervention Type DIAGNOSTIC_TEST

In this study, we need to collect an extra tube of blood for routine testing and the tissue after completion of pathological examination.

Healthy control group

Healthy crowd

tumor tissue and blood tests

Intervention Type DIAGNOSTIC_TEST

In this study, we need to collect an extra tube of blood for routine testing and the tissue after completion of pathological examination.

Interventions

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tumor tissue and blood tests

In this study, we need to collect an extra tube of blood for routine testing and the tissue after completion of pathological examination.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* No local or systemic treatment was performed before surgery. The patients were finally diagnosed with HBV-related HCC by examination and imaging examination, and the clinicopathologic data were complete.