Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-09-30

Study Completion Date

2026-03-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness based on Electroencephalography and Auditory Event-related Potentials

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Brain Network Analysis of Anesthesia Characteristics in Patients With pDoC Based on PSG

NCT06157008

Disorders of Consciousness

RECRUITING

Effects of Propofol on Auditory Event-related Potentials and Brain Functional Connectivity in Patients With Supratentorial Glioma

NCT05352685

Propofol Glioma Auditory Event-related Potential (AERP) +2 more

UNKNOWN NA

Effects of Propofol on Brain Function in Patients With Parkinson's Disease

NCT05895019

PD - Parkinson's Disease

RECRUITING

Effect of Esketamine on Conscious State in Patients With pDoC

NCT06389344

Esketamine Consciousness Disorders

RECRUITING NA

The Effects of Different Anesthetics on Functional Connectivity

NCT03343873

Sedation

RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Consciousness Disorder

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

OTHER

* Age 18 - 65 years old, native Chinese speaker, dextromanuality;
* Chronic disorder of consciousness;
* Spinal cord electrical stimulator implantation under general anesthesia;
* Signed informed consent.

Exclusion Criteria

* Continuous sedation was administered within 72 hours prior to the study;
* Open head injury, parenchymatectomy and other damage of brain structural integrity;
* The intracranial compliance decreased due to hydrocephalus and swelling;
* Known hearing impairment;
* Airway stenosis and various causes of severe ventilation or ventilation dysfunction;
* Known or suspected cardiac dysfunction;
* Allergic to intravenous general anesthetics;
* Associated with other mental or neurological diseases;
* Other reasons are not suitable to participate in this study.

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes