Renal Denervation in Patients With Recurrent Atrial Fibrillation After Successful Pulmonary Vein Isolation

NCT ID: NCT05817318

Last Updated: 2025-11-18

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-06-27
• Study Completion Date: 2026-12-31

Brief Summary

The aim of this study is to investigate whether renal denervation can reduce arrhythmia burden in patients with recurrent, paroxysmal atrial fibrillation despite durable pulmonary vein isolation.

Detailed Description

Pulmonary vein isolation is the treatment of choice in symptomatic patients with paroxysmal atrial fibrillation. Despite durable pulmonary vein isolation, 15% of patients continue to have episodes of atrial fibrillation because of triggers of atrial fibrillation localized outside the pulmonary veins. Additional ablation of these triggers is difficult because they often cannot be localized. The autonomous nervous system does influence these triggers and modulation of the autonomous nervous system with the goal to reduce sympathetic activity may be an alternative approach to suppress these extra-pulmonary vein triggers. Renal denervation does reduce sympathetic activity and is successfully used to treat drug-resistant arterial hypertension. The combination of pulmonary vein isolation with renal denervation has already been shown to be superior to pulmonary vein isolation alone in patients with paroxysmal atrial fibrillation regarding arrhythmia-free outcome. The investigators hypothesize that renal denervation can suppress atrial fibrillation in patients with recurrent episodes of paroxysmal atrial fibrillation despite durable isolation of the pulmonary veins.

The best way to assess atrial fibrillation burden is with an implantable cardiac monitor (ICM), which the investigators will use both before and after renal denervation, to gather detailed data on daily atrial fibrillation burden.

Conditions

Arrhythmia Burden in Patients With Recurrent, Paroxysmal Atrial Fibrillation Despite Durable Pulmonary Vein Isolation

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Pre-to-post renal denervation treatment

Pre-to-post treatment comparison

Group Type: OTHER

Renal Denervation

Intervention Type: DEVICE

Arrhythmia burden pre-to-post renal denervation as assessed by an implantable cardiac monitor

Interventions

Renal Denervation

Arrhythmia burden pre-to-post renal denervation as assessed by an implantable cardiac monitor

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Informed Consent signed by the subject
• ≥ 18 years of age
• Recurrent, paroxysmal atrial fibrillation post repeat (≥2) pulmonary vein isolation
• Documentation of atrial fibrillation ≥3 months after the last atrial fibrillation ablation procedure by a 12-lead ECG or on a rhythm strip of ≥30 seconds duration
• Either an office systolic blood pressure ≥130 mmHg at the screening visit or antihypertensive drug therapy

Exclusion Criteria

• Persistent or permanent atrial fibrillation post pulmonary vein isolation
• Left ventricular ejection fraction <40%
• Severe aortic or mitral valve stenosis
• Treatment with amiodaron within the last 3 months
• Mandatory treatment with class I or III antiarrhythmic drugs
• History of reflex syncope, syncope due to orthostatic hypotension or unclear syncope in the past 3 years.
• History of orthostatic hypotension
• Abnormal blood pressure fall during active standing, defined as a progressive and sustained fall in systolic blood pressure from baseline value ≥20 mmHg or diastolic blood pressure ≥10mmHg, or a decrease in systolic blood pressure to <90 mmHg.
• Prior renal denervation
• Renal artery stent or prior renal angioplasty
• Polycystic kidney disease, unilateral kidney, or history of renal transplant
• Estimated glomerular filtration rate (eGFR) < 50mL/min, using the CKD-EPI creatinine equation (Chronic Kidney Disease Epidemiology)
• Female of childbearing potential (age <50 years and last menstruation within the last 12 months), who did not undergo tubal ligation, ovariectomy or hysterectomy.
• Life expectancy <1 year
• Enrolment in interventional studies if the other study does not allow enrolment or if primary endpoint might be affected by study participation.
• Diabetes mellitus type I
• Aortic grafts

• Episodes of atrial fibrillation on <6 days in the 3 months run-in phase.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Medtronic

INDUSTRY

Sponsor Role: collaborator

Insel Gruppe AG, University Hospital Bern

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Laurent Roten, Prof

Role: PRINCIPAL_INVESTIGATOR

Insel Gruppe AG

Locations

Universitätsspital Basel

Basel, , Switzerland

Inselspital Bern

Bern, , Switzerland

Countries

Switzerland

Other Identifiers

REDE-AF

Identifier Type: -

Identifier Source: org_study_id