The Assessment of Curcuma Longa Potentials for Soft and Hard Tissue Healing in Fresh
NCT ID: NCT05816707
Last Updated: 2024-03-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE1
30 participants
INTERVENTIONAL
2024-05-01
2025-08-01
Brief Summary
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Detailed Description
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Eligibility criteria:
Inclusion Criteria for participants:
1. Patients with bilateral badly decayed mandibular posterior tooth that need extraction.
2. Patients free from any systemic disease
3. Patients who approved to be included in the trial and signed the informed consent.
4. Patients with no signs or symptoms of acute periapical\\ periodontal infection.
5. Adults aged between 18-50 years old.
Exclusion criteria for participants:
1. Patients who are allergic to Curcumin
2. Smoker patient
3. Patients receiving chemotherapy or radiotherapy.
4. Patients who refused to be included in the trial.
Interventions:
1. Diagnosis
* All patients will be diagnosed and selected according to inclusion and exclusion criteria.
* Comprehensive clinical examination and understanding of patient's chief complains and needs will be done.
* Standard preoperative intra-oral photographs (occlusal and lateral)
* (Pre-operative orthopantogram\* will be taken to ensure absence of any periapical infection)
2. Intra-operative procedures:
Local anesthesia\* will be injected intraoral around selected teeth. Patients will rinse by antiseptic mouthwash\*\* 30 seconds before extraction. Teeth will be extracted a-traumatically as possible to avoid any soft tissue or bony damage.
The extracted sockets will be debrided by bone curettes and saline. The three extraction sockets will be divided into three groups: control group, curcumin group, and PRF group.
After curcumin/ PRF placement, all sockets will be closed by simple interrupted suture\*\*\*
3. Postoperative treatment Analgesics \*\*\*\* every 6 hours for 3 days
4. Concomitant care None needed.
5. Follow up \& Evaluation.
* The extraction site will be inspected clinically after 3 days for signs of infection.
* Soft tissue healing and pain score will be assessed after 7, 14, and 21 days.
* 3 months post-operatively, each patient will undergo radiographic assessment by using Cone Beam Computed Tomography\*\*\*\*\*\* (CBCT) to evaluate bone healing and bone density.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Control
extraction socket .
extraction socket
extraction socket
PRF Group
extraction socket and PRF
PRF
Teeth will be extracted a-traumatically as possible to avoid any soft tissue or bony damage.
The extracted sockets will be debrided by bone curettes and saline. The three extraction sockets will be divided into three groups: control group, curcumin group, and PRF group.
After curcumin/ PRF placement, all sockets will be closed by simple interrupted suture
extraction socket
extraction socket
Curcuma Longa Group
Extraction Socket and Curcuma Longa
Curcuma Longa gel
Curcuma Longa gel
extraction socket
extraction socket
Interventions
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PRF
Teeth will be extracted a-traumatically as possible to avoid any soft tissue or bony damage.
The extracted sockets will be debrided by bone curettes and saline. The three extraction sockets will be divided into three groups: control group, curcumin group, and PRF group.
After curcumin/ PRF placement, all sockets will be closed by simple interrupted suture
Curcuma Longa gel
Curcuma Longa gel
extraction socket
extraction socket
Eligibility Criteria
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Inclusion Criteria
2\. Patients free from any systemic disease 3. Patients who approved to be included in the trial and signed the informed consent.
4\. Patients with no signs or symptoms of acute periapical\\ periodontal infection.
5\. Adults aged between 18-50 years old.
Exclusion Criteria
18 Years
50 Years
ALL
Yes
Sponsors
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Rania Farouk Mohamed Abdulmaguid
OTHER
Responsible Party
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Rania Farouk Mohamed Abdulmaguid
Associate Professor Oral medicine and periodontology faculty of dentistry MSA university
Locations
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Rania Farouk
Cairo, , Egypt
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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REC-D652-3
Identifier Type: -
Identifier Source: org_study_id
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