Drinking Water PFAS, Pregnancy Outcome and Maternal Morbidity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

256659 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-01-01

Study Completion Date

2018-12-31

Brief Summary

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The aim of the project is to assess the association between exposure to per- and polyfluoroalkyl substances (PFAS) via drinking water in pregnancy and birth outcomes (i.e. growth retardation, premature birth, and congenital developmental defects) and maternal morbidity (gestational hypertension, diabetes and preeclampsia) in a prospective population-wide register study.

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Detailed Description

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Conditions

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Birth Weight Small for Gestational Age at Delivery Large for Gestational Age at Delivery (Macrosomia) Diabetes, Gestational Hypertension in Pregnancy Preeclampsia Congenital Malformation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Per- and polyfluoroalkyl substances (PFAS)

Assess the association between exposure to per- and polyfluoroalkyl substances (PFAS) via drinking water in pregnancy and birth outcomes (i.e. growth retardation, premature birth, and congenital developmental defects) and maternal morbidity (gestational hypertension, diabetes and preeclampsia) in a prospective population-wide register based cohort.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Pregnant women residing in Swedish localities with a population exceeding 10,000 inhabitants and giving birth during 2012-2018

Exclusion Criteria

* Lack of data of PFAS levels in municipal drinking water (entire localities excluded)
* Mothers not living in the study area consistently between first trimester and four years prior to birth

Eligible Sex

ALL

Accepts Healthy Volunteers

No