Preterm Birth and Biomarkers for Cardiovascular Disease

NCT ID: NCT05693285

Last Updated: 2023-01-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

65 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-11-14

Study Completion Date

2022-12-02

Brief Summary

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Preterm birth is associated with maternal increased risk of cardiovascular disease later in life. In an observational case- control study, investigators want to evaluate whether women with preterm birth have increased levels of biomarkers for cardiovascular disease, to reveal potential pathophysiological mechanisms in common.

Detailed Description

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Women with spontaneous preterm birth in first pregnancy and a group of matched controls with spontaneous birth in normal time where invited to participate in the study. Participants were identified from the Biobank of Pregnant Women in Uppsala. Levels of cardiovascular biomarkers will be analyzed in plasma samples from the pregnancy and at a follow-up visit where investigators also collect information about other cardiovascular risk factors and lipid status.

Conditions

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Preterm Birth Cardiovascular Diseases

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Preterm birth

Women with spontaneous preterm birth in first pregnancy

No intervention

Intervention Type OTHER

No intervention

Controls

Matched controls with spontaneous delivery in normal time in first pregnancy

No intervention

Intervention Type OTHER

No intervention

Interventions

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No intervention

No intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Women identified as cases or controls

Exclusion Criteria

* System inflammatory disease
* Smoking at the time of the pregnancy
Maximum Eligible Age

60 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Uppsala University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Christina Christersson

Role: PRINCIPAL_INVESTIGATOR

Uppsala University

Locations

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Department of Medical Sciences, Uppsala University

Uppsala, , Sweden

Site Status

Countries

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Sweden

References

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Cederlof ET, Lager S, Larsson A, Sundstrom Poromaa I, Lindahl B, Wikstrom AK, Christersson C. Biomarkers associated with cardiovascular disease in women with spontaneous preterm birth: A case-control study. Acta Obstet Gynecol Scand. 2024 May;103(5):970-979. doi: 10.1111/aogs.14813. Epub 2024 Feb 20.

Reference Type DERIVED
PMID: 38379394 (View on PubMed)

Other Identifiers

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UU

Identifier Type: -

Identifier Source: org_study_id

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