Maternal and Offspring Outcomes in Pregnant Women With Pre-existing ASCVD

NCT ID: NCT06406998

Last Updated: 2024-05-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

5461222 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-01-01

Study Completion Date

2024-12-31

Brief Summary

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A growing body of evidence supports associations between cardiovascular health and adverse pregnancy outcome and between adverse pregnancy outcome and atherosclerotic cardiovascular disease and builds on the well-established pathways known to exist between cardiovascular health and atherosclerotic cardiovascular disease across the life course and intergenerationally. Furthermore, previous studies frequently lack comprehensive long-term follow-up, making it difficult to assess the enduring impacts of maternal cardiovascular health on postpartum outcomes and long-term maternal and child health.

Detailed Description

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the current study aimed to evaluate the associations between maternal pre-existent atherosclerotic cardiovascular disease and adverse pregnancy outcomes, and the combined effect of maternal pre-existent atherosclerotic cardiovascular disease and adverse pregnancy outcomes on the risk of long-term adverse events of offspring.

Conditions

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Cardiovascular Diseases Atherosclerosis Pregnancy Complications Adverse Cardiac Event Adverse Birth Outcomes

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Pregnant women with pre-existing atherosclerotic cardiovascular disease

Among the total cohort, pregnant women with pre-existing atherosclerotic cardiovascular disease were selected (N=145,315).

Pre-existing atherosclerotic cardiovascular disease

Intervention Type OTHER

Presence of pre-existing atherosclerotic cardiovascular disease

Matched cohort

Among the total cohort, 1:4 matched offspring born to women without pre-existent atherosclerotic cardiovascular disease using a propensity score were generated (N=581,260).

No interventions assigned to this group

Interventions

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Pre-existing atherosclerotic cardiovascular disease

Presence of pre-existing atherosclerotic cardiovascular disease

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Women with live birth from Korea (between January 1, 2005 to December 31, 2019)

Exclusion Criteria

* None
Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Samsung Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Ki Hong Choi

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ki Hong Choi, MD

Role: PRINCIPAL_INVESTIGATOR

Samsung Medical Center

Locations

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Samsung Medical Center

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Ki Hong Choi

Role: CONTACT

82-2-3410-3419

Danbee Kang, PhD

Role: CONTACT

82-2-2148-7197

Facility Contacts

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Ki Hong Choi, MD

Role: primary

82-2-3410-3419

Other Identifiers

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CVD_OBS

Identifier Type: -

Identifier Source: org_study_id

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