Gamified Adaptive Approach Bias Modification on Individuals With Methamphetamine Use History

NCT ID: NCT05794438

Last Updated: 2023-07-18

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 139 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-03-10
• Study Completion Date: 2023-07-15

Brief Summary

A randomized controlled trial will be conducted to investigate whether a proposed algorithm that adjusts the congruency ratio based on the user's performance and difficulty can enhance the effectiveness of approach bias modification. Methamphetamine users will be recruited and randomized into an algorithm group, a standard group, and a control group.

Detailed Description

To assess the efficacy of an adaptive approach bias modification (A-ApBM) paradigm with gamified designs and dynamic difficulty adjustments in reducing cue-induced craving in individuals with methamphetamine use history. DESIGN: Randomized controlled trial with three study groups: Adaptive ApBM (A-ApBM), Static ApBM (S-ApBM), and control. A-ApBM and S-ApBM groups engaged in ApBM training using a smartphone application for four weeks. A-ApBM used an adaptive algorithm to dynamically adjust the difficulty level based on individual performance, while S-ApBM had a static difficulty level. Cue-induced craving scores were assessed using a visual analog scale at baseline, post-intervention, and at week-16 follow-up.

Conditions

Addiction, Substance

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Adaptive Approach Bias Modification

Group Type: EXPERIMENTAL

Adaptive Approach Bias Modification

Intervention Type: BEHAVIORAL

In the adaptive approach bias modification, users were instructed to swipe upward when they see portrait format images and swipe downward when they see landscape format images. A shrinking animation comes after swiping upward to simulate the visual effect of moving away (approach), and a growing animation comes after swiping downward to simulate the visual effect of moving towards (avoidance). Two types of images, namely drug-related and non-drug-related, were used in the training. The drug-related images were related to methamphetamine (methamphetamine crystals, powders, and paraphernalia), and the non-drug-related images were related to healthy lifestyles (wealth, sports, gourmet, family activities, etc). An algorithm continuously monitors the performance of the user and adjusts the ratio of congruent and incongruent trials accordingly to attain a desired difficulty curve.

Static Approach Bias Modification

Group Type: EXPERIMENTAL

Static Approach Bias Modification

Intervention Type: BEHAVIORAL

In the static approach bias modification, users were instructed to swipe upward when they see portrait format images and swipe downward when they see landscape format images. A shrinking animation comes after swiping upward to simulate the visual effect of moving away (approach), and a growing animation comes after swiping downward to simulate the visual effect of moving towards (avoidance). Two types of images, namely drug-related and non-drug-related, were used in the training. The drug-related images were related to methamphetamine (methamphetamine crystals, powders, and paraphernalia), and the non-drug-related images were related to healthy lifestyles (wealth, sports, gourmet, family activities, etc).

Control

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Static Approach Bias Modification

In the static approach bias modification, users were instructed to swipe upward when they see portrait format images and swipe downward when they see landscape format images. A shrinking animation comes after swiping upward to simulate the visual effect of moving away (approach), and a growing animation comes after swiping downward to simulate the visual effect of moving towards (avoidance). Two types of images, namely drug-related and non-drug-related, were used in the training. The drug-related images were related to methamphetamine (methamphetamine crystals, powders, and paraphernalia), and the non-drug-related images were related to healthy lifestyles (wealth, sports, gourmet, family activities, etc).

Intervention Type: BEHAVIORAL

Adaptive Approach Bias Modification

In the adaptive approach bias modification, users were instructed to swipe upward when they see portrait format images and swipe downward when they see landscape format images. A shrinking animation comes after swiping upward to simulate the visual effect of moving away (approach), and a growing animation comes after swiping downward to simulate the visual effect of moving towards (avoidance). Two types of images, namely drug-related and non-drug-related, were used in the training. The drug-related images were related to methamphetamine (methamphetamine crystals, powders, and paraphernalia), and the non-drug-related images were related to healthy lifestyles (wealth, sports, gourmet, family activities, etc). An algorithm continuously monitors the performance of the user and adjusts the ratio of congruent and incongruent trials accordingly to attain a desired difficulty curve.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• having a history of methamphetamine use of at least one year

Exclusion Criteria

• could not fluently operate an Android or an iOS smartphone
• having mental health conditions other than MUD

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Adai Technology (Beijing) Co., Ltd.

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Gao Ping Town Community Drug Rehabilitation Center

Luocheng, Sichuan, China

Han Zhou Street Community Drug Rehabilitation Center

Luocheng, Sichuan, China

Jin Lun Town Community Drug Rehabilitation Center

Luocheng, Sichuan, China

Jin Yan Street Community Drug Rehabilitation Center

Luocheng, Sichuan, China

Jin Yu Town Community Drug Rehabilitation Center

Luocheng, Sichuan, China

Lian Shan Town Community Drug Rehabilitation Center

Luocheng, Sichuan, China

Nan Feng Town Community Drug Rehabilitation Center

Luocheng, Sichuan, China

San Shui Town Community Drug Rehabilitation Center

Luocheng, Sichuan, China

Sanxingdui Town Community Drug Rehabilitation Center

Luocheng, Sichuan, China

SixTwentySix Service Center, Luo Cheng Street, Guanghan City

Luocheng, Sichuan, China

Xiang Yang Town Community Drug Rehabilitation Center

Luocheng, Sichuan, China

Xiao Han Town Community Drug Rehabilitation Center

Luocheng, Sichuan, China

Countries

China

Other Identifiers

TS001

Identifier Type: -

Identifier Source: org_study_id