The Application of Cognitive Rehabilitation Therapy for Amphetamine-type Stimulants Addiction

NCT ID: NCT03318081

Last Updated: 2020-01-13

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-10-20
• Study Completion Date: 2018-05-01

Brief Summary

The computerized cognitive rehabilitation therapy will be used to treat amphetamine-type stimulant (ATS) addiction.

Detailed Description

The deficits in executive functions related to prefrontal-striatal circuits play a vital role in ATS addiction and relapse, and proposed computerized cognitive rehabilitation therapy as the novel interventions. Focused on evaluating and training executive functions including working memory, inhibitory control, cognitive flexibility, and congitive bias concerning prefrontal-striatal circuits, neuropsychological tests, electroencephalography tests, magnetic resonance spectroscopy (MRS) and functional MRI will be used to evaluate the therapeutic effect of ATS addiction treatment as well as investigate the mechanisms. The study will be very helpful to develop novel interventions in clinical practice and decrease ATS-related harm for both the patients and their families.

Conditions

Amphetamine Addiction

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

cognitive function rehabilitation group

The main content of cognitive function rehabilitation esecutive function,including working memory,sustained attention, response inhibition function and cognitive flexibility, 45 minutes a day over 6 weeks period.

Group Type: ACTIVE_COMPARATOR

cognitive function rehabilitation and bias modification

Intervention Type: BEHAVIORAL

cognitive rehabilitation focus on the deficits executive funcitin and elevated cognitive bias

cognitive bias modification group

The main content of cognitive bias modification groups were changing ATS related attention bias, 45 minutes a day over 6 weeks period.

Group Type: ACTIVE_COMPARATOR

cognitive function rehabilitation and bias modification

Intervention Type: BEHAVIORAL

cognitive rehabilitation focus on the deficits executive funcitin and elevated cognitive bias

control group

Participants only accept the regular scheduled in the compulsory isolated detoxification center

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

cognitive function rehabilitation and bias modification

cognitive rehabilitation focus on the deficits executive funcitin and elevated cognitive bias

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

1. diagnosed MA dependence in accordance with the fourth edition of the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (Association, 2000);

2. more than 9 years of education;

3. aged of 18-60 years old;

4. normal vision, audition and no color blindness;

5. receive no detoxification medications during treatment and

6. right handedness.

Exclusion Criteria

1. current medical diseases that required hospitalization or regular monitoring;

2. serious physical or neurological illness that required pharmacological treatment affecting cognitive function;

3. history of major psychiatric disorder such as bipolar disorder, schizophrenia, depression and disorders of high comorbidity with substance abuse/dependence;

4. neurological diseases such as stroke, seizure, migraine, head trauma

5. substance dependence other than nicotine, within the past 5 years;

6. intelligence quotient (IQ) <70.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Shanghai Mental Health Center

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Zhao Min, PhD, MD

Role: PRINCIPAL_INVESTIGATOR

Shanghai Mental Health Center

Locations

Shanghai Compulsory Isolation Detoxification Center

Shanghai, , China

Countries

China

References

Zhu Y, Jiang H, Su H, Zhong N, Li R, Li X, Chen T, Tan H, Du J, Xu D, Yan H, Xu D, Zhao M. A Newly Designed Mobile-Based Computerized Cognitive Addiction Therapy App for the Improvement of Cognition Impairments and Risk Decision Making in Methamphetamine Use Disorder: Randomized Controlled Trial. JMIR Mhealth Uhealth. 2018 Jun 20;6(6):e10292. doi: 10.2196/10292.

Reference Type: DERIVED

PMID: 29925497 (View on PubMed)

Other Identifiers

MZhao-008

Identifier Type: -

Identifier Source: org_study_id