To Study the Effects of Cordyceps Cicadae on Vision Care

NCT ID: NCT05778409

Last Updated: 2025-06-25

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: EARLY_PHASE1
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-03-08
• Study Completion Date: 2023-08-31

Brief Summary

Cordyceps cicadae is a traditional Asian herbal medicine with a variety of bioactive substances and curative effects similar to Cordyceps Cicadae, and it has been reported that anti-dry eye and eye protection ingredients can be extracted. With the advancement of civilization, the number of patients with high myopia is increasing year by year and suffers from complications of dry eye or other eye diseases. In this study, the subjects were provided with cicadae extract or placebo in a double-blind manner, tracked the degree of visual fatigue by regular questionnaires, and measured for visual acuity, axial length and diopter. The purpose of this study is to investigate the effect of cicadae extract on visual acuity and visual fatigue, and to evaluate its potential as a health food ingredient.

Detailed Description

1. Visual acuity measurement: Snellen's Chart was used to measure visual acuity.

2. Refractive examination: Measure binocular refraction with Open Field computer refractor (Shin-Nippon Nvision K5001 Wide View).

3. Measuring the axial length of the eye: Use the multifunctional optical eyeball length measuring instrument (Lenstar) to measure the distance from the instrument to the optical paths such as the cornea, lens, and retina, and then convert to the axial length of the eye.

4. Corneal radian measurement: Use a keratometer (Bausch & Lomb Keratometer) to measure the corneal radian and curvature, and estimate the degree of corneal astigmatism.

5. Visual fatigue questionnaire survey: A visual fatigue scale questionnaire was designed using Ocular Surface Disease Index (OSDI) and Computer Vision Syndrome (CVS).

Conditions

Myopia

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Cordyceps Cicadae extract group

500 mg/ day for 1 month

Group Type: EXPERIMENTAL

Cordyceps cicadae extract

Intervention Type: BIOLOGICAL

500mg/ day for one month

Interventions

Cordyceps cicadae extract

500mg/ day for one month

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

1. Adults aged 20 or over

2. Willing to participate in this study and sign the subject's consent form

3. Myopia less than 700 degrees

Exclusion Criteria

1. Have consumed related eye care products in past 3 months

2. Those who have eye infection in the past 3 months

3. People who have been diagnosed with any eye diseases in past 3 months

4. Those who are allergic to cicadae

• Minimum Eligible Age: 20 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

China Medical University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Hui Wen Lin

Clinical Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Hui-Wen Lin, Ph.D

Role: PRINCIPAL_INVESTIGATOR

Asia University

Locations

Asia university

Taichung, , Taiwan

Countries

Taiwan

Other Identifiers

CRREC-111-087

Identifier Type: -

Identifier Source: org_study_id