Influence of Corneal Biomechanical Properties on Myopia Control
NCT ID: NCT05090592
Last Updated: 2021-10-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2021-01-01
2022-12-31
Brief Summary
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Detailed Description
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Atropine eye drops is used clinically to control the progression of myopia. In recent years, low dose Atropine eye drops (0.01%, 0.05% and 0.1%) have been proven to be effective in slowing growth of eyeball. With less negative effects, these eye drops have been widely used for school children in Taiwan. Orthokeratology is another effective tool to control myopia, and long-term wearing of Ortho-k lens can inhibit the speed of eyeball growth, it is the most useful optical treatment for myopia control.
The Corvis® ST is a combination of an air pulse tonometer with an ultra-high-speed Scheimpflug camera. The movement of the cornea is mainly influenced by three factors which can be measured by the instrument:
Intraocular pressure (IOP)，biomechanical properties of the cornea and corneal thickness. The relationship between adult corneal biomechanics and refractive error has been noted in recent years. Previous studies pointed out that corneal biomechanics analyzer (Corvis ST) can measure the deformation process of the cornea and the biomechanics parameters. These literature found that the corneas of myopic patients， esp. high myopic, have larger corneal deformation in biomechanics analysis and revealed that the corneal stiffness of myopia patients was lower. There are still few discussions about the effect of orthokeratology on corneal biomechanics and there is no research focused on the change of corneal biomechanics of low-concentration atropine user which is worthy of our further exploration.
In this study, the investigators hope to analyze the changes in corneal biomechanics of myopic children with different treatment (low concentration atropine eye drops and orthokeratology) and explore the possible mechanism of myopia control.
Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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myopic children
Myopic children use overnight orthokeratology or 0.01% atropine eye drop per night for myopia control
orthokeratology
orthokeratology wearing for myopia control
0.01 atropine
0.01% atropine eye drop prevent myopic progression
Interventions
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orthokeratology
orthokeratology wearing for myopia control
0.01 atropine
0.01% atropine eye drop prevent myopic progression
Eligibility Criteria
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Inclusion Criteria
* received Orthokeratology or 0.01% atropine for myopia control
* regular follow-up
Exclusion Criteria
* allergy to orthokeratology or atropine
* received eye surgery
* strabismus
* premature birth
8 Years
20 Years
ALL
Yes
Sponsors
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Buddhist Tzu Chi General Hospital
OTHER
Responsible Party
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Principal Investigators
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Cheng-Jen Chiu, Doctor
Role: STUDY_DIRECTOR
Tzu Chi genral hospital
Locations
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Yu-Teng Lai
Yilan, Ilan County, Taiwan
Countries
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Other Identifiers
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Buddhist TCGH
Identifier Type: -
Identifier Source: org_study_id