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Causal Relationship Between Dry Eye and Accommodative Spasm

NCT ID: NCT05120401

Last Updated: 2021-11-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-11-05

Study Completion Date

2025-10-15

Brief Summary

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To investigate the causal relationship of Sicca dry eye patients with presbyopic refractive error and accommodative spasm.

Detailed Description

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Dry eye is a disease of the ocular surface. Severe dry eye produce symptom of discomfort in and around the eye that drastically affect life quality of the patient. OSDI index is retrieve from a questionnaire specific for these dry eye symptoms, it is an internationally accepted level to reveal the severity of Dry eye disease. One part of the symptom is pain and soreness around the eye. Hyperalgesia is an increase response to a stressful/ noxious stimulus whereas allodynia is a painful response to a normally innocuous stimulus. Our hypothesis state that Sicca Dry eye upregulated inflammatory cytokine in the eye has pre-sensitized the nociceptor nerve fiber in the cornea and orbit, therefore the normally innocuous effort of accommodation and ciliary muscle contraction produce intolerable retro-orbital eye pain, which drives the patient to seek medical attention, on presentations these patient show an elevated OSDI and Pain Index (PI).

Conditions

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Dry Eye

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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dry eye with presbyopia

dry eye with presbyopia , Intervention : glasses prescrubed

presbyopia glasses

Intervention Type DEVICE

fogging for glasses for far and intermediate

dry eye with presbyopia without glasses use

no glasses use

presbyopia glasses

Intervention Type DEVICE

fogging for glasses for far and intermediate

Interventions

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presbyopia glasses

fogging for glasses for far and intermediate

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

\- dry eye

Exclusion Criteria

* under 20 year old
Minimum Eligible Age

20 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Far Eastern Memorial Hospital

OTHER

Sponsor Role lead

Responsible Party

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Lin-Chin Mai

doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Elsa LC MAI, MPH, Dr.

Role: PRINCIPAL_INVESTIGATOR

Far Eastern Memorial Hospital

Locations

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Far Eastern Memorial Hospital

New Taipei City, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Elsa LC Mai, MPH, Dr.

Role: CONTACT

Phone: 886-89667000

Email: [email protected]

Facility Contacts

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Lin-Chin Elsa Mai, Dr.

Role: primary

Other Identifiers

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110100-E

Identifier Type: -

Identifier Source: org_study_id