Effect of Dexmedetomidine As Adjuvant to Ropivacaine for Brachial Plexus Block

NCT ID: NCT05767827

Last Updated: 2024-09-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-02-01

Study Completion Date

2024-08-30

Brief Summary

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Brachial plexus block is used for upper limb surgery. Local anesthesia alone for brachial plexus block provides good operative conditions, but have short duration of postoperative analgesia. Hence, various adjuvants to local anaesthetic agents to prolong the duration of peripheral nerve, analgesia. However, results are either inconclusive or associated with side effects. The purpose of this study is to determine whether dexmedetomidine as an adjuvant to ropivacaine in brachial plexus block improve quality of block in terms of duration of post operative analgesia.

Detailed Description

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Conditions

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Local Anesthesia Adjuvants Upper Extremity Fracture Brachial Plexus Block

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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Group R

0.35% ropivacaine 20ml, 1.5% lidocaine with adrenaline 10ml = 30 ml

Group Type ACTIVE_COMPARATOR

ropivacaine, lidocaine with adrenaline

Intervention Type DRUG

Group R includes 0.35% ropivacaine 20ml, 1.5 % lidocaine with adrenaline 10ml

Group RD

0.35% ropivacaine and 1mcg/ kg dexmedetomidine (20 ml), 1.5% lidocaine with adrenaline (10ml) = 30 ml

Group Type EXPERIMENTAL

Dexmedetomidine, ropivacaine, lidocaine with adrenaline

Intervention Type DRUG

Dexmedetomidine 1mcg/kg and 0.35% ropivacaine with normal saline (20ml), 1.5% lidocaine with adrenaline (10ml) in group RD

Interventions

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ropivacaine, lidocaine with adrenaline

Group R includes 0.35% ropivacaine 20ml, 1.5 % lidocaine with adrenaline 10ml

Intervention Type DRUG

Dexmedetomidine, ropivacaine, lidocaine with adrenaline

Dexmedetomidine 1mcg/kg and 0.35% ropivacaine with normal saline (20ml), 1.5% lidocaine with adrenaline (10ml) in group RD

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* ASA physical status I and II patients, weight 45 to 74 kg
* Elective upper limb surgery under brachial plexus block

Exclusion Criteria

* known hypersensitivity or contraindication to ropivacaine, lidocaine and dexmedetomidine
* Pregnant or lactating mothers
* Hepatic, renal or cardiopulmonary abnormalities
* Long term analgesic therapy
Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nepal Medical College and Teaching Hospital

OTHER

Sponsor Role lead

Responsible Party

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Rajiv Yadav

Lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Nepal medical college

Kathmandu, Bagmati, Nepal

Site Status

Countries

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Nepal

Other Identifiers

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NepalMCTH

Identifier Type: -

Identifier Source: org_study_id

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