Effect on Markers of Cardiovascular, Reproductive and Cancer Risk From Firefighting Training
NCT ID: NCT05753254
Last Updated: 2025-08-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
NA
35 participants
INTERVENTIONAL
2023-03-10
2024-07-05
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
The training facilities of real-fire extinguishing exercises in Denmark operate using wood or natural gas fire, which will have differential gradients of smoke, soot and possibly heat. The investigators will use different training conditions to create gradients of the different stressors and investigate health effects thereof. With this approach, the investigators expect to be able to evaluate the individual contribution of the different stressors in markers of cardiovascular, cancer and reproductive health risk. The project will include approx. 35 young conscript participants on a firefighting course, followed in four sessions, three firefighting training sessions under different fire conditions (no fire, wood fire and gas fire) and one control scenario.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Exercise & Diet Effects on CV Risk in Firefighters
NCT03344198
The Influence of Cardiorespiratory Fitness on Firefighter Cardiovascular Health Under Exercise Conditions
NCT04514354
Feasibility of a Train-the-Trainer Delivered Exercise Intervention in Firefighters
NCT05287594
Impact of Team-Based Training on Compliance and Physical Fitness in Firefighters
NCT06717737
Effects Of Blood Flow Restriction Exercise Applications On Physical Fitness Parameters
NCT05225129
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
The study will have one baseline session, while conscripts are in a classroom, and three sessions of firefighting-related exercises under different fire conditions, used currently in firefighting training programs in Denmark. The three firefighting training sessions will be controlled for equivalent work exercise using full protective gear and under different ambient conditions of firefighting training:
* Firefighting equivalent work (no fire), with exercises performed in a clean environment, without fire (no ambient temperature, soot or smoke). This type of exercise precedes or complements the training under real fire conditions.
* Firefighting under wood fire (wood fire), with exposure to ambient heat, smoke and soot. This is the most common training scenario used by Danish Emergency Management Agency training centres.
* Firefighting under gas fire (gas fire), with exposure to ambient heat, and expectably less smoke and soot than with wood fire. These conditions are used in some Danish training centres, with logistical advantages (ease of turning or putting out the fire and managing the fire fuel) and unknown effect relating to exposure prevention (smoke and soot).
The order of the firefighting sessions will be as randomized as possible, and according to a selection of three sequence order options (no-wood-gas; wood-gas-no and gas-wood-no). Each campaign (corresponding to each rescue course) would desirably have one of these session sequences. It is not possible to blind the participants to the different scenarios, neither the field staff, but all the samples will be blinded for the subsequent laboratory analysis. The training sessions will have 1-3 weeks in between (accordingly with programmatic educational course schemes).
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Baseline session
Baseline measurements will be performed in the same schedule as measurements in the three other arms. In the baseline session, participants are in classroom before starting any firefighting exercise
No interventions assigned to this group
Firefighting exercises without fire
Firefighting equivalent work, with exercises performed in a clean environment, without fire (no ambient temperature, soot or smoke). This type of exercise usually precedes or complements the training under real fire conditions.
Firefighting training exercises with no fire
The participants will be performing firefighting equivalent work in a clean environment, without fire (no ambient temperature, soot or smoke).
Firefighting under wood fire
Firefighting under wood fire, with exposure to ambient heat, smoke and soot. This is the most common training scenario used in the training centres. The participants will be in teams performing pre-defined tasks (knocking down the fire, moving heavy objects, and searching and rescuing metal stand in models
Firefighting training exercises under wood fire
The participants will be in teams performing pre-defined tasks (knocking down the fire, moving heavy objects, and searching and rescuing metal stand in models), under wood fire conditions.
Firefighting under gas fire
Firefighting under gas fire, with exposure to ambient heat, and expectably less smoke and soot than with wood fire. These conditions are used in some Danish training centres, with logistical advantages (ease of turning or putting out the fire and managing the fire fuel) and unknown effect relating to exposure prevention (smoke and soot). The participants will be in teams performing pre-defined tasks (knocking down the fire, moving heavy objects, and searching and rescuing metal stand in models
Firefighting training exercises under gas fire
The participants will be in teams performing pre-defined tasks (knocking down the fire, moving heavy objects, and searching and rescuing metal stand in models), under gas fire conditions.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Firefighting training exercises with no fire
The participants will be performing firefighting equivalent work in a clean environment, without fire (no ambient temperature, soot or smoke).
Firefighting training exercises under wood fire
The participants will be in teams performing pre-defined tasks (knocking down the fire, moving heavy objects, and searching and rescuing metal stand in models), under wood fire conditions.
Firefighting training exercises under gas fire
The participants will be in teams performing pre-defined tasks (knocking down the fire, moving heavy objects, and searching and rescuing metal stand in models), under gas fire conditions.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* conscript subjects following a Rescue Specialist Educational course
Exclusion Criteria
* pregnancy,
* on prescribed medication,
* body mass index (BMI) bellow 19 or over 30,
* alcohol or drug abuse.
18 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
University of Copenhagen
OTHER
University Hospital Bispebjerg and Frederiksberg
OTHER
Rigshospitalet, Denmark
OTHER
National Research Centre for the Working Environment, Denmark
OTHER_GOV
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Maria Helena Guerra Andersen
Researcher
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Maria Helena G Andersen, PhD
Role: PRINCIPAL_INVESTIGATOR
The National Research Centre for the Working Environment (NRCWE)
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
The National Research Centre for the Working Environment
Copenhagen, , Denmark
Maria Helena Guerra Andersen
København Ø, , Denmark
Countries
Review the countries where the study has at least one active or historical site.
References
Explore related publications, articles, or registry entries linked to this study.
Andersen MHG, Saber AT, Pedersen PB, Loft S, Hansen AM, Koponen IK, Pedersen JE, Ebbehoj N, Norskov EC, Clausen PA, Garde AH, Vogel U, Moller P. Cardiovascular health effects following exposure of human volunteers during fire extinction exercises. Environ Health. 2017 Sep 6;16(1):96. doi: 10.1186/s12940-017-0303-8.
Andersen MHG, Saber AT, Clausen PA, Pedersen JE, Lohr M, Kermanizadeh A, Loft S, Ebbehoj N, Hansen AM, Pedersen PB, Koponen IK, Norskov EC, Moller P, Vogel U. Association between polycyclic aromatic hydrocarbon exposure and peripheral blood mononuclear cell DNA damage in human volunteers during fire extinction exercises. Mutagenesis. 2018 Feb 24;33(1):105-115. doi: 10.1093/mutage/gex021.
Andersen MHG, Saber AT, Pedersen JE, Pedersen PB, Clausen PA, Lohr M, Kermanizadeh A, Loft S, Ebbehoj NE, Hansen AM, Kalevi Koponen I, Norskov EC, Vogel U, Moller P. Assessment of polycyclic aromatic hydrocarbon exposure, lung function, systemic inflammation, and genotoxicity in peripheral blood mononuclear cells from firefighters before and after a work shift. Environ Mol Mutagen. 2018 Jul;59(6):539-548. doi: 10.1002/em.22193. Epub 2018 May 15.
Andersen MHG, Saber AT, Frederiksen M, Clausen PA, Sejbaek CS, Hemmingsen CH, Ebbehoj NE, Catalan J, Aimonen K, Koivisto J, Loft S, Moller P, Vogel U. Occupational exposure and markers of genetic damage, systemic inflammation and lung function: a Danish cross-sectional study among air force personnel. Sci Rep. 2021 Sep 9;11(1):17998. doi: 10.1038/s41598-021-97382-5.
Beitel SC, Flahr LM, Hoppe-Jones C, Burgess JL, Littau SR, Gulotta J, Moore P, Wallentine D, Snyder SA. Assessment of the toxicity of firefighter exposures using the PAH CALUX bioassay. Environ Int. 2020 Feb;135:105207. doi: 10.1016/j.envint.2019.105207. Epub 2019 Dec 4.
Henriksen T, Weimann A, Larsen EL, Poulsen HE. Quantification of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydro-guanosine concentrations in urine and plasma for estimating 24-h urinary output. Free Radic Biol Med. 2021 Aug 20;172:350-357. doi: 10.1016/j.freeradbiomed.2021.06.014. Epub 2021 Jun 22.
Hjollund NH, Storgaard L, Ernst E, Bonde JP, Olsen J. Impact of diurnal scrotal temperature on semen quality. Reprod Toxicol. 2002 May-Jun;16(3):215-21. doi: 10.1016/s0890-6238(02)00025-4.
Jung A, Schuppe HC. Influence of genital heat stress on semen quality in humans. Andrologia. 2007 Dec;39(6):203-15. doi: 10.1111/j.1439-0272.2007.00794.x.
Kales SN, Soteriades ES, Christophi CA, Christiani DC. Emergency duties and deaths from heart disease among firefighters in the United States. N Engl J Med. 2007 Mar 22;356(12):1207-15. doi: 10.1056/NEJMoa060357.
Keir JLA, Akhtar US, Matschke DMJ, Kirkham TL, Chan HM, Ayotte P, White PA, Blais JM. Elevated Exposures to Polycyclic Aromatic Hydrocarbons and Other Organic Mutagens in Ottawa Firefighters Participating in Emergency, On-Shift Fire Suppression. Environ Sci Technol. 2017 Nov 7;51(21):12745-12755. doi: 10.1021/acs.est.7b02850. Epub 2017 Oct 18.
Kumar K, Trzybulska D, Tsatsanis C, Giwercman A, Almstrup K. Identification of circulating small non-coding RNAs in relation to male subfertility and reproductive hormones. Mol Cell Endocrinol. 2019 Jul 15;492:110443. doi: 10.1016/j.mce.2019.05.002. Epub 2019 May 8.
Morup N, Rajpert-De Meyts E, Juul A, Daugaard G, Almstrup K. Evaluation of Circulating miRNA Biomarkers of Testicular Germ Cell Tumors during Therapy and Follow-up-A Copenhagen Experience. Cancers (Basel). 2020 Mar 23;12(3):759. doi: 10.3390/cancers12030759.
Pedersen JE, Ugelvig Petersen K, Ebbehoj NE, Bonde JP, Hansen J. Incidence of cardiovascular disease in a historical cohort of Danish firefighters. Occup Environ Med. 2018 May;75(5):337-343. doi: 10.1136/oemed-2017-104734. Epub 2018 Jan 26.
Petersen KU, Hansen J, Ebbehoej NE, Bonde JP. Infertility in a Cohort of Male Danish Firefighters: A Register-Based Study. Am J Epidemiol. 2019 Feb 1;188(2):339-346. doi: 10.1093/aje/kwy235.
Kirstine Ugelvig Petersen K, Pedersen JE, Bonde JP, Ebbehoej NE, Hansen J. Long-term follow-up for cancer incidence in a cohort of Danish firefighters. Occup Environ Med. 2018 Apr;75(4):263-269. doi: 10.1136/oemed-2017-104660. Epub 2017 Oct 21.
Pieterse B, Felzel E, Winter R, van der Burg B, Brouwer A. PAH-CALUX, an optimized bioassay for AhR-mediated hazard identification of polycyclic aromatic hydrocarbons (PAHs) as individual compounds and in complex mixtures. Environ Sci Technol. 2013 Oct 15;47(20):11651-9. doi: 10.1021/es403810w. Epub 2013 Sep 25.
Schwartz C, Bolling AK, Carlsten C. Controlled human exposures to wood smoke: a synthesis of the evidence. Part Fibre Toxicol. 2020 Oct 2;17(1):49. doi: 10.1186/s12989-020-00375-x.
Alhamdow A, Lindh C, Albin M, Gustavsson P, Tinnerberg H, Broberg K. Early markers of cardiovascular disease are associated with occupational exposure to polycyclic aromatic hydrocarbons. Sci Rep. 2017 Aug 25;7(1):9426. doi: 10.1038/s41598-017-09956-x.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
FFIKA WP4.3
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
AMFF 16-2022-03
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
H-21068847
Identifier Type: OTHER
Identifier Source: secondary_id
72403
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.