OphtAI Diagnostic Performance Validation for Automated Screening of Eye Diseases

NCT ID: NCT05752045

Last Updated: 2023-09-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

1389 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-06-28

Study Completion Date

2024-03-31

Brief Summary

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Evolucare OphtAI is a medical device offering automated, artificial intelligence powered, screening capabilities for Diabetic Retinopathy, Diabetic Macular Edema, Glaucoma, ARM and AMD, whose performances will by tested through the OphtAI-EVAL.

Detailed Description

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OphtAI-Eval: is a prospective, multicentre, post-marketing clinical follow-up study (SCAC) of diagnostic validation (comparative vs gold standard).

It aims to: validate the diagnostic performance of the OphtAI software for the automated screening of diabetic retinopathy, diabetic macular edema, glaucoma, ARM and AMD.

Evolucare OphtAI is a medical imaging console for ophthalmology, interfaced with Evolucare Imaging.

It allows the detection, by statistical learning algorithms, of the following ocular pathologies using photographs of the retina:

* Diabetic retinopathy (DR) (including gradation),
* Diabetic macular edema (DME)
* Age-related macular degeneration (AMD)
* Age-related maculopathy (ARM, early form of AMD),
* Glaucoma.

Evolucare OphtAI, is available on the French market since March 2019.

Conditions

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Diabetic Retinopathy Diabetic Macular Edema Age-Related Macular Degeneration Age-related Maculopathy Glaucoma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Imaging and clinical data will be collected from patients to be reviewed by an expert reader group providing ground truth, and the medical device will be tested against this ground truth
Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Ground truth and Results being obtained in the end of recruitment and imaging collection, there are no effects on participant or care provider. Also, experts won't be aware of AI results and vice versa.

Study Groups

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Diabetic patient group assessed for multiple eye diseases

Each patient eye disease status will be assessed by expert readers so to provide ground truth against which algorithms performances will be assessed

Group Type OTHER

Eye Fundus Double Capture for Eye Diseases Screening with OphtAI Medical Device

Intervention Type DEVICE

Double ophthalmological imaging capture of eye fundus with different fundus camera to screen patient for various eye diseases.

Interventions

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Eye Fundus Double Capture for Eye Diseases Screening with OphtAI Medical Device

Double ophthalmological imaging capture of eye fundus with different fundus camera to screen patient for various eye diseases.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

The characteristics required for a subject to take part in the research are

* Male or female over 18,
* Type 1 or 2 diabetic,
* Presenting for screening for diabetic retinopathy,
* Beneficiary of a social security scheme,
* For whom written consent has been obtained for participation in the protocol.

Exclusion Criteria

The following characteristics do not allow the subject to take part in the research:

* Patient with known DR, more severe than "minimal", including having been treated,
* Any other condition that, in the opinion of the health professionals, may interfere with their ability to complete the study or may present a significant risk,
* Presence of social, medical and/or psychological factors that may compromise the patient's adherence to the protocol,
* Simultaneously participating in another clinical research protocol or having recently participated in another research study for which the exclusion period would not be completed.

Patients who participate in this research will not be able to participate in another research at the same time. However, there is no exclusion period at the end of this research for participation in any other study.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Slb Pharma

OTHER

Sponsor Role collaborator

Assistance Publique - Hôpitaux de Paris

OTHER

Sponsor Role collaborator

BPIfrance

OTHER

Sponsor Role collaborator

Evolucare Technologies

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Aude Couturier, Dr

Role: PRINCIPAL_INVESTIGATOR

Assistance Publique - Hôpitaux de Paris

Locations

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Centre Aix Vision

Aix-en-Provence, , France

Site Status RECRUITING

CHU Brest

Brest, , France

Site Status RECRUITING

Centre Ophtalmologique Brétigny Essonne

Brétigny-sur-Orge, , France

Site Status RECRUITING

CH SUD Francilien Corbeil Essonne

Corbeil-Essonnes, , France

Site Status RECRUITING

Centre d'examens de santé de la CPAM 93

Corbeil-Essonnes, , France

Site Status RECRUITING

Retinodiab Bourgogne

Dijon, , France

Site Status RECRUITING

Clinique Honoré Cave

Montauban, , France

Site Status NOT_YET_RECRUITING

CHU Nantes

Nantes, , France

Site Status ACTIVE_NOT_RECRUITING

Retinodiab Franche-Comté

Roppe, , France

Site Status NOT_YET_RECRUITING

Diabète Occitanie

Toulouse, , France

Site Status RECRUITING

CHU Toulouse

Toulouse, , France

Site Status RECRUITING

OPHDIAT

Paris, Île-de-France Region, France

Site Status NOT_YET_RECRUITING

Countries

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France

Central Contacts

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Ophélie Flageul

Role: CONTACT

02 23 06 11 13 ext. 0033

Laurent Borderie

Role: CONTACT

0762879928 ext. 0033

Facility Contacts

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Sébastien Guigou, Dr

Role: primary

0442992151

Béatrice Cochener, Pr

Role: primary

Tanguy Thierry, Dr

Role: backup

Bénédicte Dupas, Dr

Role: primary

0183639797

Alfred Penfornis, Pr

Role: primary

0161697457

Philippe Laboulaye, Dr

Role: primary

0172595513

Catherine Creuzot-Garcher, Pr

Role: primary

Vincent Gualino, Dr

Role: primary

Pierre Bobey, Dr

Role: primary

Marie-Christine Chauchard, Dr

Role: primary

Véronique Pagot-Mathis, Dr

Role: primary

Hélène Hanaire, Pr

Role: backup

Aude Couturier, Dr

Role: primary

Ali Erginay, Dr

Role: backup

Other Identifiers

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2022-A01813-40

Identifier Type: -

Identifier Source: org_study_id

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