An MRI Ancillary Study of a Malaria Fever Investigation

NCT ID: NCT05746819

Last Updated: 2024-04-15

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 181 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-01-02
• Study Completion Date: 2024-03-31

Brief Summary

This study will seek consent from parents of children enrolled in the Malaria FEVER study to obtain neuroimaging and 12-month neuropsychiatric outcomes data and kidney function on their child. The imaging and evaluations for this observational study will occur after the child has recovered from the acute malaria infection and has otherwise completed the RCT intervention and safety evaluations.

Detailed Description

Despite eradication efforts, ~400,000 African children sustained brain injuries as a result of CNS malaria in 2016. A higher maximum temperature (Tmax) during the acute malaria infection is an established risk factor for neurologic sequelae and a randomized controlled trial (RCT) of aggressive antipyretic therapy with acetaminophen and ibuprofen conducted in Malawi and Zambia began enrollment in 2019 (R01NS102176). In that clinical trial, the primary outcome was Tmax during the acute infection. However, the antipyretic therapies used in this RCT may offer neuroprotective effects without affecting Tmax--for example, neuroprotection through anti-inflammatory mechanisms. In An MRI Ancillary Study of Malaria FEVER RCT, we propose to use neuroimaging in the context of the RCT to further evaluate the potential neuroprotective effects of aggressive antipyretic therapy for CNS malaria and explore possible mechanisms for these effects. Comparing children allocated to aggressive antipyretic therapy vs. usual care on the prevalence of structural brain abnormalities after recovery from CNS malaria will facilitate the evaluation of non-fever pathways for neuroprotection. Brain MRIs will be obtained in children enrolled in the RCT at 1- and 12-months post recovery. Analyses will be completed comparing the odds of having any structural injury based upon RCT treatment allocation and based upon (Tmax) stratified by treatment allocation to assess changes specifically related to response to therapy in terms of fever reduction. Potential mechanisms of aggressive antipyretic-related injury will be evaluated including assessments for treatment-related CNS bleeds. Neuroimaging is a well-established, valid proxy for neurological outcomes after brain injury including in pediatric CNS malaria. Adding this MRI ancillary study to our fever RCT may elucidate mechanisms of treatment-associated injury and allow for early identification of neuroprotection from aggressive antipyretic use that would otherwise require long-term follow-up for cognitive and behavioral assessments. This study will provide critical insights that could inform future neuroprotective studies of malaria that might incorporate imaging to optimize study design. It will also add to our understanding of the long term impact of severe malaria on chronic kidney disease risk in children.

Conditions

Brain Injuries; Malaria; MRI Imaging; Neurocognitive Deficits; Chronic Kidney Diseases; Behavior Problem

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Interventions

Aggressive antipyretics therapy of fever vs usual care in the Malaria RCT study

After clinical trial of the Malaria RCT study, this study will compare children allocated to aggressive antipyretic therapy vs. usual care on the prevalence of structural brain abnormalities after recovery from CNS malaria.

Intervention Type: OTHER

Other Intervention Names

NCT03399318

Eligibility Criteria

Inclusion Criteria

1. All children enrolled in the parent Malaria RCT study are eligible

2. Signed parental consent is required

3. CNS symptoms associated with malaria.

Exclusion Criteria

1. Circulatory failure (cold extremities, capillary refill > 3 seconds, sunken eyes, ↓ skin turgor)

2. Vomiting in the past 2 hours

3. Serum Cr > 1.2 mg/dL

4. A history of liver disease

5. Jaundice or a total bilirubin of >3.0mg/dL

6. A history of gastric ulcers or gastrointestinal bleeding

7. A history of thrombocytopenia or other primary hematologic disorder

8. Petechiae or other clinical indications of bleeding abnormalities

9. A known allergy to ibuprofen, acetaminophen, aspirin or any non-steroidal medication

10. Any contraindication for nasogastric tube (NGT) placement and/or delivery of enteral medications

• Minimum Eligible Age: 2 Years
• Maximum Eligible Age: 12 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

Sponsor Role: collaborator

University of Rochester

OTHER

Sponsor Role: lead

Responsible Party

Gretchen Birbeck

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Karl B Seydel, PhD

Role: PRINCIPAL_INVESTIGATOR

Michigan State University, USA

Locations

Queen Elizabeth Central Hospital

Blantyre, Southern Region, Malawi

Chipata Central Hospital

Chipata, Eastern Province, Zambia

Countries

Malawi; Zambia

References

Rubin DB. Multiple Imputation for Nonresponse in Surveys. New York, NY: John Wiley and Sons, 1987.

Reference Type: BACKGROUND

Firth D. Bias reduction of maximum likelihood estimates. Biometrika 1993;80:27-38.

Reference Type: BACKGROUND

Plewes K, Turner GDH, Dondorp AM. Pathophysiology, clinical presentation, and treatment of coma and acute kidney injury complicating falciparum malaria. Curr Opin Infect Dis. 2018 Feb;31(1):69-77. doi: 10.1097/QCO.0000000000000419.

Reference Type: BACKGROUND

PMID: 29206655 (View on PubMed)

Potchen MJ, Birbeck GL, Demarco JK, Kampondeni SD, Beare N, Molyneux ME, Taylor TE. Neuroimaging findings in children with retinopathy-confirmed cerebral malaria. Eur J Radiol. 2010 Apr;74(1):262-8. doi: 10.1016/j.ejrad.2009.02.010. Epub 2009 Apr 3.

Reference Type: RESULT

PMID: 19345538 (View on PubMed)

Potchen MJ, Kampondeni SD, Ibrahim K, Bonner J, Seydel KB, Taylor TE, Birbeck GL. NeuroInterp: a method for facilitating neuroimaging research on cerebral malaria. Neurology. 2013 Aug 6;81(6):585-8. doi: 10.1212/WNL.0b013e31829e6ed5.

Reference Type: RESULT

PMID: 23918861 (View on PubMed)

Birbeck GL, Molyneux ME, Kaplan PW, Seydel KB, Chimalizeni YF, Kawaza K, Taylor TE. Blantyre Malaria Project Epilepsy Study (BMPES) of neurological outcomes in retinopathy-positive paediatric cerebral malaria survivors: a prospective cohort study. Lancet Neurol. 2010 Dec;9(12):1173-1181. doi: 10.1016/S1474-4422(10)70270-2. Epub 2010 Nov 4.

Reference Type: RESULT

PMID: 21056005 (View on PubMed)

Carter JA, Lees JA, Gona JK, Murira G, Rimba K, Neville BG, Newton CR. Severe falciparum malaria and acquired childhood language disorder. Dev Med Child Neurol. 2006 Jan;48(1):51-7. doi: 10.1017/S0012162206000107.

Reference Type: RESULT

PMID: 16359594 (View on PubMed)

Carter JA, Mung'ala-Odera V, Neville BG, Murira G, Mturi N, Musumba C, Newton CR. Persistent neurocognitive impairments associated with severe falciparum malaria in Kenyan children. J Neurol Neurosurg Psychiatry. 2005 Apr;76(4):476-81. doi: 10.1136/jnnp.2004.043893.

Reference Type: RESULT

PMID: 15774431 (View on PubMed)

Carter JA, Neville BG, White S, Ross AJ, Otieno G, Mturi N, Musumba C, Newton CR. Increased prevalence of epilepsy associated with severe falciparum malaria in children. Epilepsia. 2004 Aug;45(8):978-81. doi: 10.1111/j.0013-9580.2004.65103.x.

Reference Type: RESULT

PMID: 15270766 (View on PubMed)

Dondorp AM, Fanello CI, Hendriksen IC, Gomes E, Seni A, Chhaganlal KD, Bojang K, Olaosebikan R, Anunobi N, Maitland K, Kivaya E, Agbenyega T, Nguah SB, Evans J, Gesase S, Kahabuka C, Mtove G, Nadjm B, Deen J, Mwanga-Amumpaire J, Nansumba M, Karema C, Umulisa N, Uwimana A, Mokuolu OA, Adedoyin OT, Johnson WB, Tshefu AK, Onyamboko MA, Sakulthaew T, Ngum WP, Silamut K, Stepniewska K, Woodrow CJ, Bethell D, Wills B, Oneko M, Peto TE, von Seidlein L, Day NP, White NJ; AQUAMAT group. Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. Lancet. 2010 Nov 13;376(9753):1647-57. doi: 10.1016/S0140-6736(10)61924-1. Epub 2010 Nov 7.

Reference Type: RESULT

PMID: 21062666 (View on PubMed)

Carter JA, Ross AJ, Neville BG, Obiero E, Katana K, Mung'ala-Odera V, Lees JA, Newton CR. Developmental impairments following severe falciparum malaria in children. Trop Med Int Health. 2005 Jan;10(1):3-10. doi: 10.1111/j.1365-3156.2004.01345.x.

Reference Type: RESULT

PMID: 15655008 (View on PubMed)

Idro R, Jenkins NE, Newton CR. Pathogenesis, clinical features, and neurological outcome of cerebral malaria. Lancet Neurol. 2005 Dec;4(12):827-40. doi: 10.1016/S1474-4422(05)70247-7.

Reference Type: RESULT

PMID: 16297841 (View on PubMed)

John CC, Bangirana P, Byarugaba J, Opoka RO, Idro R, Jurek AM, Wu B, Boivin MJ. Cerebral malaria in children is associated with long-term cognitive impairment. Pediatrics. 2008 Jul;122(1):e92-9. doi: 10.1542/peds.2007-3709. Epub 2008 Jun 9.

Reference Type: RESULT

PMID: 18541616 (View on PubMed)

Severe and complicated malaria. World Health Organization, Division of Control of Tropical Diseases. Trans R Soc Trop Med Hyg. 1990;84 Suppl 2:1-65. No abstract available.

Reference Type: RESULT

PMID: 2219249 (View on PubMed)

Corbett D, Thornhill J. Temperature modulation (hypothermic and hyperthermic conditions) and its influence on histological and behavioral outcomes following cerebral ischemia. Brain Pathol. 2000 Jan;10(1):145-52. doi: 10.1111/j.1750-3639.2000.tb00251.x.

Reference Type: RESULT

PMID: 10668904 (View on PubMed)

Greer DM, Funk SE, Reaven NL, Ouzounelli M, Uman GC. Impact of fever on outcome in patients with stroke and neurologic injury: a comprehensive meta-analysis. Stroke. 2008 Nov;39(11):3029-35. doi: 10.1161/STROKEAHA.108.521583. Epub 2008 Aug 21.

Reference Type: RESULT

PMID: 18723420 (View on PubMed)

Laptook AR, Corbett RJ. The effects of temperature on hypoxic-ischemic brain injury. Clin Perinatol. 2002 Dec;29(4):623-49, vi. doi: 10.1016/s0095-5108(02)00057-x.

Reference Type: RESULT

PMID: 12516739 (View on PubMed)

Suz P, Vavilala MS, Souter M, Muangman S, Lam AM. Clinical features of fever associated with poor outcome in severe pediatric traumatic brain injury. J Neurosurg Anesthesiol. 2006 Jan;18(1):5-10. doi: 10.1097/01.ana.0000189079.26212.37.

Reference Type: RESULT

PMID: 16369134 (View on PubMed)

Arrich J, Holzer M, Herkner H, Mullner M. Cochrane corner: hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Anesth Analg. 2010 Apr 1;110(4):1239. doi: 10.1213/ANE.0b013e3181ce8d34.

Reference Type: RESULT

PMID: 20357161 (View on PubMed)

Lin ZL, Yu HM, Lin J, Chen SQ, Liang ZQ, Zhang ZY. Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit. J Perinatol. 2006 Mar;26(3):180-4. doi: 10.1038/sj.jp.7211412.

Reference Type: RESULT

PMID: 16407967 (View on PubMed)

Low E, Boylan GB, Mathieson SR, Murray DM, Korotchikova I, Stevenson NJ, Livingstone V, Rennie JM. Cooling and seizure burden in term neonates: an observational study. Arch Dis Child Fetal Neonatal Ed. 2012 Jul;97(4):F267-72. doi: 10.1136/archdischild-2011-300716. Epub 2012 Jan 3.

Reference Type: RESULT

PMID: 22215799 (View on PubMed)

Schulzke SM, Rao S, Patole SK. A systematic review of cooling for neuroprotection in neonates with hypoxic ischemic encephalopathy - are we there yet? BMC Pediatr. 2007 Sep 5;7:30. doi: 10.1186/1471-2431-7-30.

Reference Type: RESULT

PMID: 17784966 (View on PubMed)

Smit E, Liu X, Jary S, Cowan F, Thoresen M. Cooling neonates who do not fulfil the standard cooling criteria - short- and long-term outcomes. Acta Paediatr. 2015 Feb;104(2):138-45. doi: 10.1111/apa.12784. Epub 2014 Sep 29.

Reference Type: RESULT

PMID: 25164710 (View on PubMed)

Choi HA, Badjatia N, Mayer SA. Hypothermia for acute brain injury--mechanisms and practical aspects. Nat Rev Neurol. 2012 Feb 28;8(4):214-22. doi: 10.1038/nrneurol.2012.21.

Reference Type: RESULT

PMID: 22371279 (View on PubMed)

Corry JJ. Use of hypothermia in the intensive care unit. World J Crit Care Med. 2012 Aug 4;1(4):106-22. doi: 10.5492/wjccm.v1.i4.106. eCollection 2012 Aug 4.

Reference Type: RESULT

PMID: 24701408 (View on PubMed)

Magnusson MO, Dahl ML, Cederberg J, Karlsson MO, Sandstrom R. Pharmacodynamics of carbamazepine-mediated induction of CYP3A4, CYP1A2, and Pgp as assessed by probe substrates midazolam, caffeine, and digoxin. Clin Pharmacol Ther. 2008 Jul;84(1):52-62. doi: 10.1038/sj.clpt.6100431. Epub 2007 Oct 31.

Reference Type: RESULT

PMID: 17971810 (View on PubMed)

Scaravilli V, Tinchero G, Citerio G; Participants in the International Multi-Disciplinary Consensus Conference on the Critical Care Management of Subarachnoid Hemorrhage. Fever management in SAH. Neurocrit Care. 2011 Sep;15(2):287-94. doi: 10.1007/s12028-011-9588-6.

Reference Type: RESULT

PMID: 21755388 (View on PubMed)

Chomba E, Haworth A, Atadzhanov M, Mbewe E, Birbeck GL. The socioeconomic status of children with epilepsy in Zambia: implications for long-term health and well-being. Epilepsy Behav. 2008 Nov;13(4):620-3. doi: 10.1016/j.yebeh.2008.06.008. Epub 2008 Aug 12.

Reference Type: RESULT

PMID: 18602496 (View on PubMed)

Crawley J, Smith S, Kirkham F, Muthinji P, Waruiru C, Marsh K. Seizures and status epilepticus in childhood cerebral malaria. QJM. 1996 Aug;89(8):591-7. doi: 10.1093/qjmed/89.8.591.

Reference Type: RESULT

PMID: 8935480 (View on PubMed)

Dammann O, Leviton A. Inflammation, brain damage and visual dysfunction in preterm infants. Semin Fetal Neonatal Med. 2006 Oct;11(5):363-8. doi: 10.1016/j.siny.2006.02.003. Epub 2006 Mar 31.

Reference Type: RESULT

PMID: 16581321 (View on PubMed)

Moxon CA, Chisala NV, Wassmer SC, Taylor TE, Seydel KB, Molyneux ME, Faragher B, Kennedy N, Toh CH, Craig AG, Heyderman RS. Persistent endothelial activation and inflammation after Plasmodium falciparum Infection in Malawian children. J Infect Dis. 2014 Feb 15;209(4):610-5. doi: 10.1093/infdis/jit419. Epub 2013 Sep 17.

Reference Type: RESULT

PMID: 24048963 (View on PubMed)

Langfitt JT, McDermott MP, Brim R, Mboma S, Potchen MJ, Kampondeni SD, Seydel KB, Semrud-Clikeman M, Taylor TE. Neurodevelopmental Impairments 1 Year After Cerebral Malaria. Pediatrics. 2019 Feb;143(2):e20181026. doi: 10.1542/peds.2018-1026. Epub 2019 Jan 29.

Reference Type: RESULT

PMID: 30696757 (View on PubMed)

Potchen MJ, Kampondeni SD, Seydel KB, Birbeck GL, Hammond CA, Bradley WG, DeMarco JK, Glover SJ, Ugorji JO, Latourette MT, Siebert JE, Molyneux ME, Taylor TE. Acute brain MRI findings in 120 Malawian children with cerebral malaria: new insights into an ancient disease. AJNR Am J Neuroradiol. 2012 Oct;33(9):1740-6. doi: 10.3174/ajnr.A3035. Epub 2012 Apr 19.

Reference Type: RESULT

PMID: 22517285 (View on PubMed)

Pongponratn E, Riganti M, Punpoowong B, Aikawa M. Microvascular sequestration of parasitized erythrocytes in human falciparum malaria: a pathological study. Am J Trop Med Hyg. 1991 Feb;44(2):168-75. doi: 10.4269/ajtmh.1991.44.168.

Reference Type: RESULT

PMID: 2012260 (View on PubMed)

Taylor TE, Fu WJ, Carr RA, Whitten RO, Mueller JS, Fosiko NG, Lewallen S, Liomba NG, Molyneux ME. Differentiating the pathologies of cerebral malaria by postmortem parasite counts. Nat Med. 2004 Feb;10(2):143-5. doi: 10.1038/nm986. Epub 2004 Jan 25.

Reference Type: RESULT

PMID: 14745442 (View on PubMed)

Medhi N, Das SB, Das RR, Medhi S, Sarma P, Duwara R, Das P, Saikia R. MRI findings of cerebral malaria. A report of two cases. Neuroradiol J. 2009 Aug 29;22(4):407-12. doi: 10.1177/197140090902200408. Epub 2009 Aug 29.

Reference Type: RESULT

PMID: 24207146 (View on PubMed)

Rasalkar DD, Paunipagar BK, Sanghvi D, Sonawane BD, Loniker P. Magnetic resonance imaging in cerebral malaria: a report of four cases. Br J Radiol. 2011 Apr;84(1000):380-5. doi: 10.1259/bjr/85759874.

Reference Type: RESULT

PMID: 21415303 (View on PubMed)

Potchen MJ, Kampondeni SD, Seydel KB, Haacke EM, Sinyangwe SS, Mwenechanya M, Glover SJ, Milner DA, Zeli E, Hammond CA, Utriainen D, Lishimpi K, Taylor TE, Birbeck GL. 1.5 Tesla Magnetic Resonance Imaging to Investigate Potential Etiologies of Brain Swelling in Pediatric Cerebral Malaria. Am J Trop Med Hyg. 2018 Feb;98(2):497-504. doi: 10.4269/ajtmh.17-0309. Epub 2018 Jan 4.

Reference Type: RESULT

PMID: 29313473 (View on PubMed)

Kampondeni SD, Birbeck GL, Seydel KB, Beare NA, Glover SJ, Hammond CA, Chilingulo CA, Taylor TE, Potchen MJ. Noninvasive measures of brain edema predict outcome in pediatric cerebral malaria. Surg Neurol Int. 2018 Mar 1;9:53. doi: 10.4103/sni.sni_297_17. eCollection 2018.

Reference Type: RESULT

PMID: 29576904 (View on PubMed)

Ibekwe R, Jeaven L, Wilmshurst JM. The role of melatonin to attain electroencephalograms in children in a sub-Saharan African setting. Seizure. 2017 Oct;51:87-94. doi: 10.1016/j.seizure.2017.08.002. Epub 2017 Aug 12.

Reference Type: RESULT

PMID: 28826048 (View on PubMed)

Gordon SB, Chinula L, Chilima B, Mwapasa V, Dadabhai S, Mlombe Y; Malawi Research Ethics Workshop 2018 Participants. A Malawi guideline for research study participant remuneration. Wellcome Open Res. 2018 Dec 19;3:141. doi: 10.12688/wellcomeopenres.14668.2. eCollection 2018.

Reference Type: RESULT

PMID: 30662959 (View on PubMed)

Molyneux ME, Taylor TE, Wirima JJ, Borgstein A. Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Q J Med. 1989 May;71(265):441-59.

Reference Type: RESULT

PMID: 2690177 (View on PubMed)

D'Agostino RB Jr. Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. Stat Med. 1998 Oct 15;17(19):2265-81. doi: 10.1002/(sici)1097-0258(19981015)17:193.0.co;2-b.

Reference Type: RESULT

PMID: 9802183 (View on PubMed)

Lunceford JK, Davidian M. Stratification and weighting via the propensity score in estimation of causal treatment effects: a comparative study. Stat Med. 2004 Oct 15;23(19):2937-60. doi: 10.1002/sim.1903.

Reference Type: RESULT

PMID: 15351954 (View on PubMed)

Gladstone M, Lancaster GA, Umar E, Nyirenda M, Kayira E, van den Broek NR, Smyth RL. The Malawi Developmental Assessment Tool (MDAT): the creation, validation, and reliability of a tool to assess child development in rural African settings. PLoS Med. 2010 May 25;7(5):e1000273. doi: 10.1371/journal.pmed.1000273.

Reference Type: RESULT

PMID: 20520849 (View on PubMed)

Gladstone MJ, Lancaster GA, Jones AP, Maleta K, Mtitimila E, Ashorn P, Smyth RL. Can Western developmental screening tools be modified for use in a rural Malawian setting? Arch Dis Child. 2008 Jan;93(1):23-9. doi: 10.1136/adc.2006.095471. Epub 2007 Mar 22.

Reference Type: RESULT

PMID: 17379661 (View on PubMed)

Denckla MB. Revised Neurological Examination for Subtle Signs (1985). Psychopharmacol Bull. 1985;21(4):773-800. No abstract available.

Reference Type: RESULT

PMID: 4089106 (View on PubMed)

Placencia M, Sander JW, Shorvon SD, Ellison RH, Cascante SM. Validation of a screening questionnaire for the detection of epileptic seizures in epidemiological studies. Brain. 1992 Jun;115 ( Pt 3):783-94. doi: 10.1093/brain/115.3.783.

Reference Type: RESULT

PMID: 1628202 (View on PubMed)

Placencia M, Suarez J, Crespo F, Sander JW, Shorvon SD, Ellison RH, Cascante SM. A large-scale study of epilepsy in Ecuador: methodological aspects. Neuroepidemiology. 1992;11(2):74-84. doi: 10.1159/000110915.

Reference Type: RESULT

PMID: 1495577 (View on PubMed)

Brim R, Mboma S, Semrud-Clikeman M, Kampondeni S, Magen J, Taylor T, Langfitt J. Cognitive Outcomes and Psychiatric Symptoms of Retinopathy-Positive Cerebral Malaria: Cohort Description and Baseline Results. Am J Trop Med Hyg. 2017 Jul;97(1):225-231. doi: 10.4269/ajtmh.17-0020.

Reference Type: RESULT

PMID: 28719298 (View on PubMed)

Hosmer DW, Lemeshow, S. Applied Logistical Regression. New York, NY: John Wiley and Sons, 2000.

Reference Type: RESULT

Heinze G, Schemper M. A solution to the problem of separation in logistic regression. Stat Med. 2002 Aug 30;21(16):2409-19. doi: 10.1002/sim.1047.

Reference Type: RESULT

PMID: 12210625 (View on PubMed)

Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986 Dec;51(6):1173-82. doi: 10.1037//0022-3514.51.6.1173.

Reference Type: RESULT

PMID: 3806354 (View on PubMed)

Imai K, Keele L, Tingley D. A general approach to causal mediation analysis. Psychol Methods. 2010 Dec;15(4):309-34. doi: 10.1037/a0020761.

Reference Type: RESULT

PMID: 20954780 (View on PubMed)

MacKinnon DP, Fairchild AJ, Fritz MS. Mediation analysis. Annu Rev Psychol. 2007;58:593-614. doi: 10.1146/annurev.psych.58.110405.085542.

Reference Type: RESULT

PMID: 16968208 (View on PubMed)

Conroy AL, Opoka RO, Bangirana P, Idro R, Ssenkusu JM, Datta D, Hodges JS, Morgan C, John CC. Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria. BMC Med. 2019 May 21;17(1):98. doi: 10.1186/s12916-019-1332-7.

Reference Type: RESULT

PMID: 31109328 (View on PubMed)

Plewes K, Kingston HWF, Ghose A, Wattanakul T, Hassan MMU, Haider MS, Dutta PK, Islam MA, Alam S, Jahangir SM, Zahed ASM, Sattar MA, Chowdhury MAH, Herdman MT, Leopold SJ, Ishioka H, Piera KA, Charunwatthana P, Silamut K, Yeo TW, Lee SJ, Mukaka M, Maude RJ, Turner GDH, Faiz MA, Tarning J, Oates JA, Anstey NM, White NJ, Day NPJ, Hossain MA, Roberts Ii LJ, Dondorp AM. Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial. Clin Infect Dis. 2018 Sep 14;67(7):991-999. doi: 10.1093/cid/ciy213.

Reference Type: RESULT

PMID: 29538635 (View on PubMed)

John CC, Park GS, Sam-Agudu N, Opoka RO, Boivin MJ. Elevated serum levels of IL-1ra in children with Plasmodium falciparum malaria are associated with increased severity of disease. Cytokine. 2008 Mar;41(3):204-8. doi: 10.1016/j.cyto.2007.12.008. Epub 2008 Feb 20.

Reference Type: RESULT

PMID: 18282763 (View on PubMed)

Dobbie M, Crawley J, Waruiru C, Marsh K, Surtees R. Cerebrospinal fluid studies in children with cerebral malaria: an excitotoxic mechanism? Am J Trop Med Hyg. 2000 Feb;62(2):284-90. doi: 10.4269/ajtmh.2000.62.284.

Reference Type: RESULT

PMID: 10813486 (View on PubMed)

Medana IM, Day NP, Salahifar-Sabet H, Stocker R, Smythe G, Bwanaisa L, Njobvu A, Kayira K, Turner GD, Taylor TE, Hunt NH. Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria. J Infect Dis. 2003 Sep 15;188(6):844-9. doi: 10.1086/377583. Epub 2003 Sep 9.

Reference Type: RESULT

PMID: 12964115 (View on PubMed)

Becker K, Rahlfs S, Nickel C, Schirmer RH. Glutathione--functions and metabolism in the malarial parasite Plasmodium falciparum. Biol Chem. 2003 Apr;384(4):551-66. doi: 10.1515/BC.2003.063.

Reference Type: RESULT

PMID: 12751785 (View on PubMed)

Greve B, Lehman LG, Lell B, Luckner D, Schmidt-Ott R, Kremsner PG. High oxygen radical production is associated with fast parasite clearance in children with Plasmodium falciparum malaria. J Infect Dis. 1999 Jun;179(6):1584-6. doi: 10.1086/314780.

Reference Type: RESULT

PMID: 10228089 (View on PubMed)

Clark IA, Mackie EJ, Cowden WB. Injection of free radical generators causes premature onset of tissue damage in malaria-infected mice. J Pathol. 1986 Apr;148(4):301-5. doi: 10.1002/path.1711480406.

Reference Type: RESULT

PMID: 3701495 (View on PubMed)

Divani AA, Andalib S, Di Napoli M, Lattanzi S, Hussain MS, Biller J, McCullough LD, Azarpazhooh MR, Seletska A, Mayer SA, Torbey M. Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Pathophysiological Insights. J Stroke Cerebrovasc Dis. 2020 Aug;29(8):104941. doi: 10.1016/j.jstrokecerebrovasdis.2020.104941. Epub 2020 May 12.

Reference Type: RESULT

PMID: 32689643 (View on PubMed)

Gutman JR, Lucchi NW, Cantey PT, Steinhardt LC, Samuels AM, Kamb ML, Kapella BK, McElroy PD, Udhayakumar V, Lindblade KA. Malaria and Parasitic Neglected Tropical Diseases: Potential Syndemics with COVID-19? Am J Trop Med Hyg. 2020 Aug;103(2):572-577. doi: 10.4269/ajtmh.20-0516. Epub 2020 Jun 1.

Reference Type: RESULT

PMID: 32484155 (View on PubMed)

Seydel KB, Kampondeni SD, Valim C, Potchen MJ, Milner DA, Muwalo FW, Birbeck GL, Bradley WG, Fox LL, Glover SJ, Hammond CA, Heyderman RS, Chilingulo CA, Molyneux ME, Taylor TE. Brain swelling and death in children with cerebral malaria. N Engl J Med. 2015 Mar 19;372(12):1126-37. doi: 10.1056/NEJMoa1400116.

Reference Type: RESULT

PMID: 25785970 (View on PubMed)

Davids EL, Adams Tucker L, Wambua GN, Fewster DL, Schlebusch L, Karrim SB, Attia M, Nyoni J, Bayouh FG, Kuteesa H, Brahim T, Hoogenhout M, Moussa Kahloul RB, Jearey-Graham N, Gobie HB, Nalugya JS. Child and adolescent mental health in Africa: A qualitative analysis of the perspectives of emerging mental health clinicians and researchers using an online platform. J Child Adolesc Ment Health. 2019 Sep;31(2):93-107. doi: 10.2989/17280583.2019.1659145.

Reference Type: RESULT

PMID: 31570090 (View on PubMed)

Patel AA, Jannati A, Dhamne SC, Sapuwa M, Kalanga E, Mazumdar M, Birbeck GL, Rotenberg A. EEG markers predictive of epilepsy risk in pediatric cerebral malaria - A feasibility study. Epilepsy Behav. 2020 Dec;113:107536. doi: 10.1016/j.yebeh.2020.107536. Epub 2020 Nov 21.

Reference Type: RESULT

PMID: 33232892 (View on PubMed)

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

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Document Type: Informed Consent Form: MRI Ancillary Consent Form English Version 4.1

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Document Type: Informed Consent Form: MRI Ancillary Assent Form English Version 4.0

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Other Identifiers

R01NS111057

Identifier Type: NIH

Identifier Source: secondary_id

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RSRB_STUDY00005384

Identifier Type: -

Identifier Source: org_study_id