Periocular Rejuvenation by Topical Hyaluronic Acid Nano Particles

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-12-21

Study Completion Date

2024-01-15

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

In this study, The investigators aims to evaluate the efficacy and safety of topical hyaluronic acid nanoparticles as a novel nanodermatological tool in periocular rejuvenation as a replacement approach of invasive dermal filler injections.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Evaluation of the Efficacy and Tolerability of Autologous Adipose Tissue Derived Stem Cells on Facial Rejuvenation

NCT03928444

Skin Rejuvenation

COMPLETED NA

Nanofat Versus Platelet Poor Plasma Gel for Infraorbital Rejuvenation

NCT06318091

Tear Trough Eyelid Deformity

COMPLETED PHASE1

Carboxytherapy for Periorbital Dark Circles

NCT04745078

Periorbital Disorder

COMPLETED NA

Evaluation of the Safety and Efficacy of the Pico Laser With a Specialized Lens Array for the Treatment of Wrinkles

NCT02091089

Wrinkles

COMPLETED NA

Investigating the Role of 13cis Retinoic Acid in the Treatment of COVID-19 and Enhancement of Its Spike Protein Based Vaccine Efficacy and Safety.

NCT04730895

Covid19 Vaccine

UNKNOWN PHASE1/PHASE2

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Tear trough deformity is a main concern of many people (males or females) with age range of 21 to 65 years old or older. Such condition is characterized by a sunken appearance of the eye that results in an aged and dissipated appearance to the eye.Treatment modalities range from camouflage make up, laser resurfacing, platelet-rich plasma therapy, carboxy therapy, mesotherapy, volume augmentation with injectable hyaluronic acid fillers and fat, as well as surgical procedures such as blepharoplasty. Consequently, safe, effective and less invasive treatment options of the tear trough have remained a challenge.

The study will include 30 adult patients (male or female) suffering tear trough deformity.

They will be selected from Dermatology Outpatient Clinic of Alexandria Main University Hospital.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Tear Trough Eyelid Deformity Dark Eyelids Wrinkle

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

parallel assignment

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Double

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Hyaluronic acid nanoparticles (2%)

patients with tear trough will receive hyaluronic acid nano-gel (2%) 2 applications / day (morning and evening) on tear troughs for 1 month

Group Type ACTIVE_COMPARATOR

Hyaluronic acid NanoGel

Intervention Type DRUG

Hyaluronic acid nanoparticles (2%)

Placebo

patients with tear trough will receive placebo conventional gel having the same color, form and packaging for 1 month

Group Type PLACEBO_COMPARATOR

Placebo gel

Intervention Type DRUG

conventional gel having the same color, form and packaging

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Hyaluronic acid NanoGel

Hyaluronic acid nanoparticles (2%)

Intervention Type DRUG

Placebo gel

conventional gel having the same color, form and packaging

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Is a healthy male or female between 21 and 65 years old
2. Is voluntarily willing to consent to participate in the study
3. Is willing to comply with all requirements of the study including being photographed, follow post treatment care instructions, to attend all treatment, and follow up visits
4. Willingness to waive rights to use of still photos of themselves for research, marketing, or promotional reasons, including on the internet and on social media outlets.
5. Willingness to refrain from other surgical, laser, or injectable treatments in the periorbital region during the entire duration of the study.
6. Ability to provide informed consent.