A Retrospective Assessment of OviTex PRS (OviTex)

NCT ID: NCT05736848

Last Updated: 2025-08-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-09-27

Study Completion Date

2026-12-31

Brief Summary

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The objective of this retrospective-prospective, observational study is to evaluate the safety profile overall and within two device types of OviTex PRS in previous pre-pectoral or sub-pectoral implant-based breast reconstructions.

Detailed Description

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This study is organized as a retrospective-prospective, observational, multi-center study. The treatment group involved in the study received OviTex PRS during implant-based breast reconstruction. The reconstruction procedure was an immediate or two-stage unilateral or bilateral implant in either the sub-pectoral or pre-pectoral position. Results from this study are aimed to demonstrate an acceptable safety profile and to inform the study design and effectiveness endpoints of a future prospective study.

Conditions

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Reconstructive Surgical Procedures

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Interventions

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OviTex® PRS

OviTex® PRS is a reinforced tissue matrix intended to reinforce soft tissue where weakness exists in patients requiring soft tissue repair or reinforcement in plastic and reconstructive surgery.

Intervention Type DEVICE

Other Intervention Names

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OviTex PRS Permanent - Pre-pectoral OviTex PRS Permanent - Sub-pectoral OviTex PRS Resorbable - Pre-pectoral OviTex PRS Resorbable - Sub-pectoral

Eligibility Criteria

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Inclusion Criteria

1. Patient was between 18 years and 75 years of age (inclusive) at the time of surgery.
2. At the time of surgery, the patient received an OviTex PRS Permanent (R20143 or R20243) or Resorbable (R20152 or R20252) implant in conjunction with an implant-based breast reconstruction.
3. Patient has undergone their initial surgical procedure and exchange surgery (if applicable).


1\. Patient agrees to return in-person for prospective portion including the completion of photographs.

Exclusion Criteria

1. Patient received a textured permanent breast implant.
2. Patient was a nicotine user (including smokeless, vaporized, etc.) within 4-weeks preceeding their index procedure.
3. Patient had previously undergone radiation therapy to the chest wall prior to index surgery.


1\. Patient has a history of a psychological condision, drug or alcohol abuse which may interfere with their ability to adhere to the follow-up requirements.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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MCRA

INDUSTRY

Sponsor Role collaborator

Tela Bio Inc

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Asaf Yalif, MD

Role: PRINCIPAL_INVESTIGATOR

Y Plastic Surgery

Locations

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Aesthetic Surgery Center

Naples, Florida, United States

Site Status RECRUITING

Castrellon Aesthetic Surgery

South Miami, Florida, United States

Site Status RECRUITING

Y Plastic Surgery

Alpharetta, Georgia, United States

Site Status ACTIVE_NOT_RECRUITING

Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status RECRUITING

Janineh Plastic Surgery

Rochester Hills, Michigan, United States

Site Status COMPLETED

David L. Abramson, MD

Englewood, New Jersey, United States

Site Status RECRUITING

Capital Health

Pennington, New Jersey, United States

Site Status RECRUITING

Strong Memorial Hospital

Rochester, New York, United States

Site Status COMPLETED

Plastic Surgery Consultants

Columbia, South Carolina, United States

Site Status RECRUITING

Dermatology Associates of San Antonio/Baptist Medical Center

San Antonio, Texas, United States

Site Status COMPLETED

Houston Methodist The Woodlands Hospital

The Woodlands, Texas, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Zachary Sterner

Role: CONTACT

937-514-2262

Danielle Campbell

Role: CONTACT

717-676-2589

Facility Contacts

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Sherry Johnson

Role: primary

239-420-8141

Alexia Stamatiou

Role: primary

786-928-0174

Matthew DePamphilis

Role: primary

Zoe Robertson

Role: primary

Nancy Brunetti

Role: primary

800-637-2374

Samantha Schneider

Role: primary

Jennifer Garrett

Role: primary

Other Identifiers

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TB2022.01.02

Identifier Type: -

Identifier Source: org_study_id

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