Cohort of Twin Pregnancy and the Offspring

NCT ID: NCT05727085

Last Updated: 2025-03-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-10-15

Study Completion Date

2029-06-15

Brief Summary

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Twin pregnancy increases the risk of maternal and fetal complications, which include gestational hypertension, premature labor, twin-to-twin transfusion syndrome, intrauterine growth restriction, anemia, amniotic fluid abnormalities. Comprehensively understanding the molecular mechanisms of the disease and identification of markers contribute to development of novel therapeutic approaches. In addition, the twin pregnancy, especially the monochorionic, is an essential model of "experiments of nature". This model can be applied to distinguish the epigenetic differences of twins in utero and after birth in the same genomic context. The aim of the study is to constitute a prospective cohort of twin pregnancies and the offspring.

Detailed Description

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Data are collected regarding the pregnancy data of the mother, and mental, physical and sociodemographic information of the offspring. The periods span from diagnosis of twins to 3 years old of the offspring. Biological samples would be collected including maternal blood, placental tissues, cord blood, urine, and stool from the pregnant women or the offspring at the specific time.

The total estimated duration of the study is 6 years, of which the first 2.5 years will correspond to the recruitment period of the participants.

Conditions

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Twin Pregnancy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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twins

All pregnant women with a twin pregnancy and the offspring

Intervention Type OTHER

No intervention

Interventions

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All pregnant women with a twin pregnancy and the offspring

No intervention

Intervention Type OTHER

Other Intervention Names

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No intervention

Eligibility Criteria

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Inclusion Criteria

1. Maternal age \>18 years old.
2. Twin pregnancy.

Exclusion Criteria

1. Fetal chromosomal or congenital abnormalities.
2. Stillbirth.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Fudan University

OTHER

Sponsor Role lead

Responsible Party

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Yu Xiong

Clinical Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Obstetrics and Gynecology Hospital of Fudan University

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Facility Contacts

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Yu Xiong, phd

Role: primary

+862163455050

Other Identifiers

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TW20231535

Identifier Type: -

Identifier Source: org_study_id

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