Study to Investigate Outcome of Individualized Treatment in Patients With Metastatic Colorectal Cancer

NCT ID: NCT05725200

Last Updated: 2023-02-21

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-09-27
• Study Completion Date: 2040-12-31

Brief Summary

The purpose of the study is to investigate the effect and side effects of personalized cancer treatment in patients with metastatic colorectal cancer (bowel cancer). All patients included must have metastatic bowel cancer and receive or have received at least two lines of standard chemotherapy. The cancer must not be available for surgery with curative intent.

Detailed Description

The purpose of the study is to evaluate individualized systemic anti-cancer treatment of metastatic colorectal cancer (mCRC), selected by a combined pharmacogenomic drug sensitivity profile with a molecular profiling of the tumor tissue and an ex vivo drug sensitivity testing of patient-derived organoids (PDOs). The combined pharmacogenomic drug sensitivity profile will be provided by Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital (OUS) and will be a result of either i) a pre-screening performed in this study or ii) from previous biomarker analyses and drug sensitivity testing of PDOs as part of an ongoing translational research project at Dept. of Molecular Oncology. The combined pharmacogenomic profile will be interpreted by an institutional multidisciplinary tumor board (MTB), and in cases where the MTB strongly suggests that the patient will benefit from one of the interventions offered by this study, the patient will be invited to participate. No formal hypotheses testing will be performed in the study, but it aims to show that it is feasible, in an unselected population of patients with mCRC, to select patients for individualized therapy based on a broad genomic and transcriptomic profiling and ex vivo drug sensitivity testing of cultured PDOs from the patient's own tumor cells, and to provide evidence that a combined pharmacogenomic profile can predict objective antitumor responses to systemic anticancer therapies, including drugs not approved for treatment of patients with mCRC, in the setting of third-line therapy or in later lines. In addition, this study will be part of several translational research projects at the Department of Molecular Oncology.

Conditions

Metastatic Colorectal Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Individualized treatment in patients with metastatic colorectal cancer

Interventions with anti-cancer drugs having marketing authorisation in Norway will be used in this study.

The intervention will be study drugs as monotherapy or treatment with approved combinations.

This trial will facilitate access to potentially effective interventions to which they would otherwise not have access.

Group Type: EXPERIMENTAL

Alectinib

Intervention Type: DRUG

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current Summary of Product Characteristics (SMPC) and package Insert.

Cetuximab

Intervention Type: DRUG

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Crizotinib

Intervention Type: DRUG

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Dasatinib

Intervention Type: DRUG

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Everolimus

Intervention Type: DRUG

Dosage form, dosage, frequency and duration are described in the current SMPC and package Insert.

Encorafenib

Intervention Type: DRUG

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Gemcitabine

Intervention Type: DRUG

Dosage form, dosage, frequency and duration are described in the current SMPC and package Insert.

Idelalisib

Intervention Type: DRUG

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Larotrectinib

Intervention Type: DRUG

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Methotrexate

Intervention Type: DRUG

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Palbociclib

Intervention Type: DRUG

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Panobinostat

Intervention Type: DRUG

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Pembrolizumab

Intervention Type: DRUG

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Petrozumab

Intervention Type: DRUG

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Trastuzumab

Intervention Type: DRUG

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Talazoparib

Intervention Type: DRUG

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Venetoclax

Intervention Type: DRUG

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Interventions

Alectinib

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current Summary of Product Characteristics (SMPC) and package Insert.

Intervention Type: DRUG

Cetuximab

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Intervention Type: DRUG

Crizotinib

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Intervention Type: DRUG

Dasatinib

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Intervention Type: DRUG

Everolimus

Dosage form, dosage, frequency and duration are described in the current SMPC and package Insert.

Intervention Type: DRUG

Encorafenib

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Intervention Type: DRUG

Gemcitabine

Dosage form, dosage, frequency and duration are described in the current SMPC and package Insert.

Intervention Type: DRUG

Idelalisib

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Intervention Type: DRUG

Larotrectinib

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Intervention Type: DRUG

Methotrexate

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Intervention Type: DRUG

Palbociclib

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Intervention Type: DRUG

Panobinostat

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Intervention Type: DRUG

Pembrolizumab

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Intervention Type: DRUG

Petrozumab

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Intervention Type: DRUG

Trastuzumab

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Intervention Type: DRUG

Talazoparib

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Intervention Type: DRUG

Venetoclax

Dosage form, dosage, frequency and duration are to be implemented by study investigators as described in the current SMPC and package Insert.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Has a histologically-proven locally advanced or metastatic adenocarcinoma from colon or rectum
• Has received or is receiving systemic treatment for mCRC
• Has non-resectable metastases and eligible to undergo a radiological-guided core biopsy from at least one metastasis
• Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
• Has measurable or evaluable disease (per RECIST v1.1)
• Is capable of giving signed informed consent, as described in Appendix 1, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol

1. Has a histologically-proven locally advanced or metastatic adenocarcinoma from colon or rectum (mCRC)

2. Has received at least two lines of SOC chemotherapy for mCRC Note: 1) For patients who develop a metastatic relapse < 6 months after completed total neo-adjuvant treatment in conjunction with a metastasectomy, this treatment will be considered as one line (e.g. first-line) chemotherapy. 2) Patients with the gene RAS wild-type tumors should have received or have been offered and refused prior treatment with antibodies against epidermal growth factor receptor (EGFR) (e.g. in combination with prior lines of chemotherapy) unless it was contraindicated due to underlying conditions or the tumor contains molecular alterations suggested to provide primary resistance to EGFR-targeted therapy.

3. Has full combined pharmacogenomic profile (genomic and transcriptomic profile of the patients tumor and ex vivo drug sensitivity testing of PDOs from the patient's own tumors cells) from which the MTB suggests a treatment with one of the defined targeted anti-cancer therapies provided this study

4. Has measurable or evaluable disease (per RECIST v1.1)

5. ECOG performance status 0 or 1

6. For orally administered drugs, the participant must be able to swallow and tolerate oral medication and must have no known malabsorption syndrome.

7. Because of the risks of drug treatment to a developing fetus, women of child-bearing potential and men must agree to use adequate contraception in accordance with the respective SmPC and as listed in Appendix 4 for the duration of study participation, and up to 7 months following completion of study therapy. Male study patients, even if surgically sterilized, (i.e. post-vasectomy) must agree to one of the following: practice effective barrier contraception during the entire study treatment period and through 6 months after the last dose of study drug, or completely abstain from sexual intercourse.

1. Absolute neutrophil count ≥ 1.5/nL (nL = nano Litre)

2. Hemoglobin > 10 g/dL

3. Platelets > 100/nL

4. Total bilirubin < 1.5 x institutional upper limit of normal (ULN)

5. Aspartate aminotransferase AST (SGOT) and alanine aminotransferase ALT(SGPT) < 2.5 x institutional upper limit of normal (ULN) (or < 5 x ULN in patients with known hepatic metastases)

6. Calculated or measured creatinine clearance ≥ 50 mL/min/1.73 m2

Exclusion Criteria

• Has other clinically significant medical conditions which, in the opinion of the treating physician, makes it undesirable for the patient to participate in the study or which could jeopardize compliance with study requirements.

MAIN STUDY:

1. Has ongoing toxicity > CTCAE grade 2, other than peripheral neuropathy and alopecia, related to anti-tumor treatment that was completed within 4 weeks prior to registration. Patients with ongoing peripheral neuropathy of ≥ CTCAE grade 3 will be excluded.

2. Has received previous treatment with the selected study drug for the same malignancy.

5. Is pregnant or breastfeeding or refusing any type of required contraception methods.

6. Has known Central Nervous System (CNS) metastases.

7. Has preexisting cardiac conditions, including uncontrolled or symptomatic angina, uncontrolled atrial or ventricular arrhythmias, or symptomatic congestive heart failure.

8. Has left ventricular ejection fraction (LVEF) known to be < 40%.

9. Has had a stroke (including TIA) or an acute myocardial infarction within 6 months before the first dose of study treatment.

10. Has had acute gastrointestinal bleeding within 1 month of start of treatment

11. Has other clinically significant medical conditions which, in the opinion of the treating physician, makes it undesirable for the patient to participate in the study or which could jeopardize compliance with study requirements.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Oslo University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Tormod Kyrre Guren, MD

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Tormod K Guren, MDPhD

Role: PRINCIPAL_INVESTIGATOR

Oslo University Hospital

Locations

Oslo University Hospital

Oslo, , Norway

Site Status: RECRUITING

Countries

Norway

Central Contacts

Tormod K Guren, MDPhD

Role: CONTACT

uxtour@ous-hf.no

+4722934000

Facility Contacts

Tormod K Guren, MDPhD

Role: primary

Other Identifiers

EVIDENT

Identifier Type: -

Identifier Source: org_study_id