Genotyping of Metastatic Colorectal Cancer Patients for Precision Medicine Clinical Trials

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-10-31

Study Completion Date

2019-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The goal of delivering the right drug to the right cancer patient (precision medicine) requires a detailed understanding of how genomic alterations are linked to drug response. The purpose of this study is to intercept at point-of-care a large cohort of newly diagnosed mCRC patients to determine if it is possible to obtain personalized genetic information from each subject's tumor (tissue and blood) to triage treatment choices. In case of target positivity, patients will be conveyed, whenever possible, to self-standing, independent, hypothesis-driven POC trials as soon as they exhibit resistance to standard of care treatment.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Study of Target-Guided Chemotherapy in Metastatic Colorectal Patients

NCT01453257

Progression Free Survival

COMPLETED PHASE2

Efficacy Study of a Maintenance Therapy With Immunomodulator MGN1703 in Patients With Advanced Colorectal Carcinoma

NCT01208194

Advanced Colorectal Carcinoma

COMPLETED PHASE2

Gene Expression Analysis of Patients With Metastatic Colorectal Cancer Receiving Oxaliplatin Based Chemotherapy Regimen

NCT00250029

Colonic Diseases Cancer

COMPLETED NA

Mechanistic and Molecular Study of the Process of Metastatic Dissemination in Colorectal Cancer

NCT03613194

Colorectal Cancer

UNKNOWN NA

Observational Study to Evaluate the Use of Targeted Therapies in Metastatic Colorectal Cancer

NCT02254941

Metastatic Colon Cancer

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Metastatic Colorectal Cancer

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Histological confirmed adenocarcinoma of the colon or rectum with metastatic disease not amenable to salvage surgery.
* Planned primary treatment at FUNNEL center or FUNNEL center referring Hospital.
* Availability of fresh tissue or a paraffin block for genotyping NOT older than 1 year.
* Age ≥18.
* ECOG PS 0-1.
* No major comorbidities that would preclude the potential enrolment of the patient in a clinical trial.
* Signed informed consent.

Exclusion Criteria

* Symptomatic brain metastases.
* Gastro-intestinal abnormalities, inability to take oral medication, any condition affecting absorption.
* History of another neoplastic disease (except basal cell carcinoma of the skin or uterine cervix carcinoma in situ adequately treated), unless in remission for ≥ 5 years.
* No major comorbidities that would preclude the potential enrolment of the patient in a clinical trial.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No