Research of New Serological Markers for the Diagnosis and Monitoring of Candidaemia in Hospitalized Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-05-14

Study Completion Date

2022-02-17

Brief Summary

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Bloodstream infections due to Candida spp remain a serious medical challenge because of their high incidence and poor outcome. Diagnosis and monitoring of patients are still problematic, hindering efficient clinical management of the disease. The invastigators propose here to perform a retrospective study in a clinically well-characterized candidemic patient, with the goal of recognizing host immunological factors and virulence-associated fungal molecules relevant in the onset and evolution of infection. The researchers' ultimate goal is to identify new diagnostic and/or prognostic benchmarks useful in clinical settings. By combining serologic and immunologic expertise with clinical expertise, the research team has real potential to generate new markers of host pathogenesis and immune response in candidemia and to inform prospective clinical trials to control this terrible disease

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Detailed Description

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Conditions

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Candida Infection

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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collection of blood samples

For each patient, a serum sample collected at the time when candidemia is suspected (time of execution of blood cultures) will be examined. For patients with candidemia, all serum samples taken during infection follow-up will also be examined.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* patients hospitalized
* one or more positive blood cultures for Candida spp,
* positive beta-glucanemia
* the presence of at least one clinical symptom of infection will be considered cases of candidemia.

Exclusion Criteria

* age less than 18 years
* state of immunosuppression
* incompleteness of clinical data
* unavailability of serum samples in sufficient quantities for analysis and in good condition.

Eligible Sex

ALL

Accepts Healthy Volunteers

No