Salivary Cystatin S Levels in a Group of Egyptian Children

NCT ID: NCT05716867

Last Updated: 2025-02-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-12-01

Study Completion Date

2025-05-10

Brief Summary

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Aim of the study

1. Measuring the levels of salivary cystatin S protein and salivary buffering capacity to determine their relation to early childhood caries.
2. Predection of early childhood caries by using salivary cystatin S levels with demographic, clinical and nutrition habits characteristics of the participants.

Detailed Description

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Conditions

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Early Childhood Caries

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Children with early childhood caries aged between 36-71 month

Measurement of salivary cystatin S protein levels in saliva

Intervention Type BIOLOGICAL

The human cystatin S enzyme-linked immunosorbent assay (ELISA) kit will be used to measure the amounts of cystatin S in saliva for cases and controls

Caries free children aged between 36-71 month

Measurement of salivary cystatin S protein levels in saliva

Intervention Type BIOLOGICAL

The human cystatin S enzyme-linked immunosorbent assay (ELISA) kit will be used to measure the amounts of cystatin S in saliva for cases and controls

Interventions

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Measurement of salivary cystatin S protein levels in saliva

The human cystatin S enzyme-linked immunosorbent assay (ELISA) kit will be used to measure the amounts of cystatin S in saliva for cases and controls

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Medically free children aged 36 to 71 months with one or more decayed (noncavitated or cavitated lesions), missing, or filled teeth due to caries in any primary tooth(cases).
* Medically free children aged 36 to 71 months with no decayed, missing, or filled teeth due to caries in any primary tooth(controls).

Exclusion Criteria

* Children receiving antibiotic therapy within three month and fluoride prophylaxis within one year.
* Parents who will refuse to participate or refuse to sign the informed consent.
* Children who will not agree or cooperate with participation.
Minimum Eligible Age

36 Months

Maximum Eligible Age

71 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cairo University

OTHER

Sponsor Role lead

Responsible Party

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Tasneem Salah Sayed Mohamed Abo Ali

principle investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Faculty of Oral and Dental Medicine Cairo University

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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PEDO 1-2-1

Identifier Type: -

Identifier Source: org_study_id

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