Radiomics Model for the Diagnosis of Pneumocystis Jirovecii Pneumonia in Non-HIV Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

140 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-01-15

Study Completion Date

2023-06-30

Brief Summary

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To evaluate the performance of radiomics in differentiating Pneumocystis jirovecii pneumonia (PCP) from other types of pneumonia and to improve the diagnostic efficacy of non-invasive tests in non-HIV patients.

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Detailed Description

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Retrospective study, including non-HIV patients hospitalized for suspected PCP from January 2010 to December 2022. The included patients were randomized in a 7:3 ratio into training and validation cohorts. Radiomic features were extracted from semi-automatically identified infected areas in computed tomography (CT) scans and used to construct a radiomic model, which was then compared to a clinical-imaging model built with clinical and semantic CT features in terms of diagnostic performance of PCP. The combination of the radiomic model and serum β-D-glucan levels was also evaluated for PCP diagnosis.

Conditions

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Pneumocystis Jirovecii Pneumonia

Study Design

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Observational Model Type

OTHER

Study Time Perspective

OTHER

Study Groups

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non-HIV patients hospitalized for suspected PCP

Radiomic model

Intervention Type DIAGNOSTIC_TEST

Radiomic model for PCP diagnosis

Interventions

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Radiomic model

Radiomic model for PCP diagnosis

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* aged over eighteen years;
* presence of an underlying disease known to be associated with PCP
* symptoms of lower respiratory tract infection, such as fever, cough or dyspnea
* signs of lung infection on high resolution CT at the on-set of the disease
* received BAL examination within three days after CT scans
* underwent qPCR and IF staining tests on the BAL fluid sample.